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  • 1.
    Stålman, Cecilia
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Nilsson, Johnny
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences. Karolinska institutet.
    Ryhed, Anna
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Godhe, Manne
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet.
    A novel aerobic test, 5-minute-pyramid-test, useful in school to monitor VO2max2019In: AISEP International Conference 2019 Book of abstracts, 2019, p. 402-Conference paper (Other academic)
  • 2.
    Péter, Annamária
    et al.
    University of Jyväskylä, Jyväskylä, Finland.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet, Sweden.
    Hegyi, András
    University of Jyväskylä, Jyväskylä, Finland.
    Finni, Taija
    University of Jyväskylä, Jyväskylä, Finland.
    Tarassova, Olga
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Cronin, Neil
    University of Jyväskylä, Jyväskylä, Finland.
    Grundström, Helen
    Capio S:t Göran's Hospital, Stockholm, Sweden.
    Arndt, Anton
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet, Sweden.
    Comparing Surface and Fine-Wire Electromyography Activity of Lower Leg Muscles at Different Walking Speeds.2019In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 10, article id 1283Article in journal (Refereed)
    Abstract [en]

    Ankle plantar flexor muscles are active in the stance phase of walking to propel the body forward. Increasing walking speed requires increased plantar flexor excitation, frequently assessed using surface electromyography (EMG). Despite its popularity, validity of surface EMG applied on shank muscles is mostly unclear. Thus, we examined the agreement between surface and intramuscular EMG at a range of walking speeds. Ten participants walked overground at slow, preferred, fast, and maximum walking speeds (1.01 ± 0.13, 1.43 ± 0.19, 1.84 ± 0.23, and 2.20 ± 0.38 m s-1, respectively) while surface and fine-wire EMG activities of flexor hallucis longus (FHL), soleus (SOL), medial gastrocnemius (MG) and lateral gastrocnemius (LG), and tibialis anterior (TA) muscles were recorded. Surface and intramuscular peak-normalised EMG amplitudes were compared for each muscle and speed across the stance phase using Statistical Parametric Mapping. In FHL, we found differences around peak activity at all speeds except fast. There was no difference in MG at any speed or in LG at slow and preferred speeds. For SOL and LG, differences were seen in the push-off phase at fast and maximum walking speeds. In SOL and TA, surface EMG registered activity during phases in which intramuscular EMG indicated inactivity. Our results suggest that surface EMG is generally a suitable method to measure MG and LG EMG activity across several walking speeds. Minimising cross-talk in FHL remains challenging. Furthermore, SOL and TA muscle onset/offset defined by surface EMG should be interpreted cautiously. These findings should be considered when recording and interpreting surface EMG of shank muscles in walking.

  • 3.
    Larsson, Kristina
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Kallings, Lena
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Blom, Victoria
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Sport Psychology research group.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Ekblom, Maria
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Criterion validity and test-retest reliability of SED-GIH, a single item question for assessment of daily sitting time.2019In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 19, no 1, article id 19:17Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Sedentary behaviour has been closely linked to metabolic and cardiovascular health and is therefore of importance in disease prevention. A user-friendly tool for assessment of sitting time is thus needed. Previous studies concluded that the present tools used to assess a number of sedentary behaviours are more likely to overestimate sitting than single-item questions which often underestimate sitting time, and that categorical answering options are recommended. In line with this, the single-item question with categorical answering options, SED-GIH, was developed. The aim of this study was to investigate the criterion validity of the SED-GIH question using activPAL3 micro as the criterion measure. The second aim was to evaluate the test-retest reliability of the SED-GIH questionnaire.

    METHOD: In the validity section of this study, 284 middle-aged adults answered a web questionnaire, which included SED-GIH, wore activPAL and filled in a diary log for one week. Spearman's rho assessed the relationship between the SED-GIH answers and the daily average sitting time as monitored by the activPAL (activPAL-SIT), a Weighted Kappa assessed the agreement, ANOVA assessed differences in activPAL-SIT between the SED-GIH answer categories, and a Chi2 compared the proportions of hazardous sitters between the different SED-GIH answer categories. In the reliability section, 95 elderly participants answered the SED-GIH question twice, with a mean interval of 5.2 days. The reliability was assessed with ICC and a weighted Kappa.

    RESULTS: The SED-GIH question correlated moderately with activPAL-SIT (rho = 0.31), with a poor agreement (weighted Kappa 0.12). In total, 40.8% underestimated and 22.2% overestimated their sitting time. The ANOVA showed significant differences in activPAL-SIT between the different SED-GIH answer categories (p < 0.001). The Chi2 showed a significant difference in proportion of individuals sitting more than 10 h per day within each SED-GIH answer category. ICC for the test-retest reliability of SED-GIH was excellent with ICC = 0.86, and the weighted Kappa showed an agreement of 0.77.

    CONCLUSIONS: The unanchored single item SED-GIH question showed excellent reliability but poor validity in the investigated populations. Validity and reliability of SED-GIH is in line with other questionnaires that are commonly used when assessing sitting time.

  • 4.
    Peter, Annamaria
    et al.
    University of Jyväskylä, Finland.
    Arndt, Anton
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet.
    Finni, Taija
    University of Jyväskylä, Finland.
    Hegyi, Andras
    University of Jyväskylä, Finland.
    Tarassova, Olga
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Cronin, Neil
    University of Jyväskylä, Finland.
    Effect of footwear on plantar flexor fine-wire electromyography activity in walking.2019In: Footwear Science. 2019 Supplement, Vol. 11, p S120-S121: Proceedings of the Fourteenth Footwear Biomechanics Symposium (Kananaskis, Canada, 2019), Taylor & Francis, 2019, Vol. 11, p. S120-S121Conference paper (Other academic)
  • 5.
    Godhe, Manne
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Ekblom, Maria
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska Institutet.
    Pontén, Marjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska Institutet.
    Improved daily movement patterns in an accelerometer-assessed 8-weeks exercise project in older adults2019In: British Journal of Sports Medicine Vol 53, suppl 1, BMJ Publishing Group Ltd, 2019, Vol. 53, p. A2-Conference paper (Other academic)
  • 6.
    Stavestrand, Silje Haukenes
    et al.
    University of Bergen, Norway.
    Sirevåg, Kristine
    University of Bergen, Norway.
    Nordhus, Inger Hilde
    University of Bergen, Norway.
    Sjøbø, Trond
    Solli DPS, Nesttun, Norway.
    Endal, Trygve Bruun
    Solli DPS, Nesttun, Norway.
    Nordahl, Hans M
    Norwegian University of Science and Technology, Trondheim, Norway..
    Specht, Karsten
    University of Bergen, Norway.
    Hammar, Åsa
    University of Bergen, Norway.
    Halmøy, Anne
    University of Bergen, Norway.
    Martinsen, Egil W
    University of Oslo, Norway.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Hjelmervik, Helene
    University of Bergen, Norway.
    Mohlman, Jan
    William Paterson University, NJ, USA.
    Thayer, Julian F
    Ohio State University, OH, USA.
    Hovland, Anders
    University of Bergen, Norway.
    Physical exercise augmented cognitive behaviour therapy for older adults with generalised anxiety disorder (PEXACOG): study protocol for a randomized controlled trial.2019In: Trials, ISSN 1745-6215, E-ISSN 1745-6215, Vol. 20, no 1, article id 174Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Generalised anxiety disorder (GAD) is a frequent and severe anxiety disorder among older adults. GAD increases the risk of developing other disorders such as depression and coronary heart disease. Older adults with GAD exhibit a poorer response to cognitive behaviour therapy (CBT) compared to younger patients with GAD. The normal age-related cognitive decline can be a contributor to reduced treatment efficacy. One strategy for improving treatment efficacy is to combine CBT with adjunctive interventions targeted at improving cognitive functions. Physical exercise is a viable intervention in this regard. Increased levels of brain-derived neurotrophic factor may mediate improvement in cognitive function. The present study aims to investigate the proposed effects and mechanisms related to concomitant physical exercise.

    METHODS: The sample comprises 70 participants aged 60-75 years, who have GAD. Exclusion criteria comprise substance abuse and unstable medication; inability to participate in physical exercise; and conditions which precludes GAD as primary diagnosis. The interventions are individual treatment in the outpatient clinic at the local psychiatric hospital, with two experimental arms: (1) CBT + physical exercise and (2) CBT + telephone calls. The primary outcome measure is symptom reduction on the Penn State Worry Questionnaire. Other measures include questionnaires, clinical interviews, physiological, biological and neuropsychological tests. A subset of 40 participants will undergo magnetic resonance imaging (MRI). After inclusion, participants undergo baseline testing, and are subsequently randomized to a treatment condition. Participants attend five sessions of the add-on treatment in the pre-treatment phase, and move on to interim testing. After interim testing, participants attend 10 sessions of CBT in parallel with continued add-on treatment. Participants are tested post-intervention within 2 weeks of completing treatment, with follow-up testing 6 and 12 months later.

    DISCUSSION: This study aims to develop better treatment for GAD in older adults. Enhancing treatment response will be valuable from both individual and societal perspectives, especially taking the aging of the general population into account.

    TRIAL REGISTRATION: ClinicalTrials.gov, NCT02690441 . Registered on 24 February 2016.

  • 7.
    Alfven, G
    et al.
    Karolinska Institutet.
    Grillner, S
    Karolinska Institutet.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet.
    Review of childhood pain highlights the role of negative stress.2019In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227Article, review/survey (Refereed)
    Abstract [en]

    AIM: Recurrent pain of unknown origin is a major problem in children. The aim of the present review was to examine the hypothesis of negative stress as an aetiology of recurrent pain from different aspects.

    METHODS AND RESULTS: Epidemiological studies, clinical experience and hormonal data give support for such a hypothesis. Negative stress as a tentative aetiology for recurrent pain is reviewed. Stress, muscular tension, the startle reaction and its tentative relation to pain is illuminated. Deviations of hormonal secretion supporting a stress aetiology is mentioned. The role of central sensitization for recurrent pain is discussed. Possible aetiological implications of recurrent pain as a local symptom or a general disorder are presented. Brain changes due to stress is shortly reviewed. Stress and pain in the clinic are highlighted. The importance of biological, psychological and social factors, as well as genetic elements, are-Ddiscussed.

    CONCLUSION: Stress elicits neurobiological mechanisms. They may lead to many neurophysiological deviances. Increase of muscle tension and neuromuscular excitability and enhanced startle reaction may be of importance for recurring pain. The identification of stress as a primary cause of recurrent pain can have huge implications for understanding signs and treatment in clinical practice. This article is protected by copyright. All rights reserved.

    The full text will be freely available from 2020-06-04 12:00
  • 8.
    Bratland-Sanda, Solfrid
    et al.
    University College of Southeast Norway.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet.
    Best, James
    Jaeren Psychiatric Center, Norway.
    Høegmark, Simon
    Naturama Museum, Denmark.
    Roessler, Kirsten Kaya
    University of Southern Denmark.
    The use of physical activity, sport and outdoor life as tools of psychosocial intervention: the Nordic perspective2019In: Sport in Society: Cultures, Media, Politics, Commerce, ISSN 1743-0437, E-ISSN 1743-0445, Vol. 22, no 4, SI, p. 654-670Article in journal (Refereed)
    Abstract [en]

    The core values in the Nordic welfare model are health equality and social inclusion. Individuals with mental disorders and/or a history of substance use disorder are often excluded from the core value of equality. Psychosocial interventions such as physical activity and outdoor life can have several benefits for those suffering from mental disorders. Firstly, such interventions can have therapeutic effects. Secondly, they show benefits for somatic health and the risk of lifestyle-related diseases. Finally, they can provide an environment for experiencing self-efficacy, lead to improved quality of life, and promote the development and building of social relationships. This paper provides a critical review of current evidence for physical activity and outdoor life as psychosocial interventions in psychiatric and substance misuse treatment, with specific examples from Norway, Sweden and Denmark.

  • 9.
    da Silva, Julio Cézar Lima
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Ekblom, Maria
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet.
    Tarassova, Olga
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet.
    Rönquist, Gustaf
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Grundström, Helene
    Danderyds Hospital.
    Arndt, Anton
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet.
    Effect of increasing workload on knee extensor and flexor muscular activity during cycling as measured with intramuscular electromyography.2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 8, article id e0201014Article in journal (Refereed)
    Abstract [en]

    The purpose of this study was to describe the effect of increasing workload on individual thigh muscle activation during a 20 minute incremental cycling test. Intramuscular electromyographic signals were recorded from the knee extensors rectus femoris, vastus lateralis, vastus medialis and vastus intermedius and the knee flexors semimembranosus, semitendinosus, and the short and long heads of the biceps femoris during increasing workloads. Mean activation levels were compared over the whole pedaling cycle and the crank angles at which onset and offset of activation and peak activity occurred were identified for each muscle. These data were compared between three workloads. EMG activation level significantly increased (p<0.05) with increasing workload in the rectus femoris, vastus medialis, vastus lateralis, vastus intermedius, biceps femoris long head, semitendinosus and semimembranosus but not in the biceps femoris short head. A significant change in activation timing was found for the rectus femoris, vastus lateralis, vastus medialis and semitendinosus. Of the knee flexors only the short head of the biceps femoris had its peak activity during the upstroke phase at the two highest workloads indicating a unique contribution to knee flexion.

  • 10.
    Andersson, Eva
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Oddsson, Kristjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    von Rosen, Philip
    Karolinska institutet.
    Idrottsskador: Skadeförebyggande metoder, rehabilitering och akut omhändertagande2018In: Specialidrott: Tränings- och tävlingslära, Stockholm: SISU idrottsböcker , 2018, p. 143-177Chapter in book (Other (popular science, discussion, etc.))
  • 11.
    Peter, Annamaria
    et al.
    Neuromuscular Research Center, University of Jyväskylä, Finland.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Arndt, Anton
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Finni, T
    Neuromuscular Research Center, University of Jyväskylä, Finland.
    Cronin, NJ
    Neuromuscular Research Center, University of Jyväskylä, Finland.
    Impact of footwear type and walking speed on ankle plantar flexor fine-wire electromyographic activity2018In: Sport science at the cutting edge, 2018Conference paper (Refereed)
    Abstract [en]

    INTRODUCTION:

    Ankle plantar flexors substantially contribute to propulsion in human walking, and their relative contributions may be affected by the type of footwear used. In this study, we aimed to examine plantar flexor fine-wire electromyography (wEMG) activity in different footwear types and barefoot walking. We further examined the effect of walking speed on the relative activity of ankle plantar flexors.

    METHODS:

    Nine healthy people volunteered to this study (five males) with two sessions. In session 1, participants were familiarized to the study protocol. In session 2, electrical activity of flexor hallucis longus (FHL), soleus (SOL), medial and lateral gastrocnemius (MG and LG) muscles were measured with wEMG during eight overground walking tasks: preferred speed walking with shoes, barefoot and with flip-flops; with shoes: 30% slower and faster than preferred speed walking with shoes, and maximum walking speed; walking barefoot and with flip-flops at the same speed as preferred speed walking with shoes (matched speed). Then they performed maximal isometric plantar flexion contractions and maximal big toe flexions superimposed on ankle plantar flexion (MVICs) in an isokinetic dynamometer for wEMG normalization. Root mean square activity was calculated in the push-off phase of individual step cycles based on ground reaction force data. The relative contribution of each muscle to propulsion was calculated as: (mean RMS value %MVIC of the given muscle / mean RMS value %MVIC of all muscles) * 100. Cohen’s d±90% confidence intervals were calculated to define the magnitude of differences.

    RESULTS:

    In all muscles, wEMG activity increased with speed. With increasing speed the relative contribution to propulsion increased in FHL (from 19 to 22%), did not change in SOL (32%), decreased in MG (from 32 to 25%) and increased in LG (from 18 to 21%). There were no differences between preferred and matched barefoot walking speed or wEMG activity level (d range = 0.06-0.17). wEMG activity for all muscles was lower during matched barefoot walking than preferred speed walking with shoes (7-10% MVIC, d range=0.31-0.47). Flip-flop data are under analysis.

    CONCLUSION:

    We found that relative wEMG activity of the examined muscles was affected by speed and absence or presence of shoes. During barefoot walking, wEMG activity of plantar flexor muscles was lower than during shod walking at the same speed, which presumably means that shod walking limits the contribution of intrinsic foot muscles to propulsion, which should be further examined.

    REFERENCES:

    1 Murley GS, Menz HB, Landorf KB. (2014). Gait & Posture, 39(4), 1080-5.

    2 Goldmann JP, Potthast W, Brüggemann GP. (2013). Footwear Sci, 5 (1): 19-25.

    3 Franklin et al., Gait & Posture. 60: 1-5, 2018.

    CONTACT:

    annamaria.a.peter@jyu.fi

  • 12. Martinsen, E
    et al.
    Hovland, A
    Kjellman, B
    Taube, J
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Om depression2018In: Fysisk aktivitet som medicin: En praktisk handbok utifrån FYSS / [ed] Ing-Marie Dohrn, Stockholm: SISU idrottsböcker , 2018, p. 177-182Chapter in book (Other (popular science, discussion, etc.))
  • 13. Hovland, A
    et al.
    Martinsen, EW
    Taube, J
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Kjellman, B
    Om ångestsyndrom2018In: Fysisk aktivitet som medicin: En praktisk handbok utifrån FYSS / [ed] Ing-Mari Dohrn, Stockholm: SISU idrottsböcker , 2018, p. 293-298Chapter in book (Other (popular science, discussion, etc.))
  • 14.
    Sirevåg, K
    et al.
    University of Bergen, Faculty of Psychology, Solli DPS, Nestun, Norway.
    Stavestrand, S
    Endal, T
    Sjøbø, T
    Nordhus, IH
    Pallesen, S
    Nordahl, H
    Specht, K
    Martinsen, EW
    Hammar, Å
    Mohlman, J
    Halmøy, A
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Thayer, JF
    Hjelmervik, H
    Hovland, A
    Physical EXercise Augmented COGnitive Behaviour Therapy for Older Adults with Generalised Anxiety Disorder (PEXACOG)2018Conference paper (Refereed)
    Abstract [en]

    Generalised anxiety disorder (GAD) is the most prevalent severe anxiety disorder among older adults. The disorder has a pervasive influence on the lives of those affected, and is a risk factor for other severe disorders such as depression, dementia and coronary heart disease. Cognitive behaviour therapy (CBT) is the treatment of choice for this disorder, but older adults have shown reduced effect of treatment compared to working age adults. Physical exercise has been suggested as intervention to improve the effects of treatment for GAD, via its demonstrated positive effect on cognitive functioning, increased plasticity in the brain, and increased availability of neurotrophins important for extinction of fear associations. The aim of the current research project is to investigate whether augmenting CBT with physical exercise will lead to improved effects of CBT on GAD in older adults in a randomized controlled trial (RCT). Participants between 60-75 years of age with a primary diagnosis of GAD will be randomised to one of two treatment conditions. The effects of treatment will be assessed on outcome measures, biological, physiological and cognitive measures at pre- interim-, and post-treatment, and follow-up assessments at 6- and 12-months post intervention. Participants in both groups will receive five weeks of pre-treatment intervention consisting of either physical exercise or weekly telephone contact. Participants thereafter receive either ten weeks of manualised CBT for GAD combined with manualised physical exercise or ten weeks of manualised CBT for GAD combined with weekly telephone contact. We expect that the treatment effect of the physical exercise augmented CBT will be greater than that of CBT combined with weekly telephone contact, as measured by a reduction in GAD symptoms on the Penn State Worry Questionnaire and in the proportion of remitted patients. The study also aims to determining the possible beneficial and augmenting properties of physical exercise in combination with CBT, and our understanding of clinical characteristics of GAD and mechanisms involved in treatment effect. Treatment rationale, procedures and protocols will be presented in detail together with preliminary results from the initial feasibility study comprises eight participants

  • 15.
    Sirivåg, K
    et al.
    University of Bergen, Faculty of Psychology, Bergen,Solli DPS, Nesttun, Norway.
    Haukenes Stavestrand, S
    Hilde Nordhus, I
    Pallesen, S
    Sjøbø, T
    Bruun Endal, T
    Nordahl, HM
    Specht, K
    Hammar, Å
    Halmøy, A
    Martinsen, EW
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Hjelmervik, H
    Mohlman, J
    Thayer, JF
    Hovland, A
    Physical exercise augmented cognitive behaviour therapy for older adults with generalised anxiety disorder (PEXACOG): Study protocol and feasibility results from a randomised controlled trial2018Conference paper (Refereed)
    Abstract [en]

    Background. Generalised anxiety disorder (GAD) is prevalent among older adults. These patients exhibit impaired response to cognitive behaviour therapy (CBT), and physical exercise has been recommended as a potential add-on intervention to improve efficacy. The current study is a randomised clinical trial that will compare CBT augmented with physical exercise, or CBT combined with attention placebo, and the current study assessing the feasibility of testing procedures and the experimental combined treatment measures.

    Methods. 4 participants were included in the feasibility study, and feasibility was assessed trough completion and attendance rates of testing and treatment sessions. Primary outcome measures were remission as assessed by an independent clinical rater using the Anxiety Disorders Interview Schedule for DSM-IV, and by symptom reduction on Penn State Worry Questionnaire. Manipulation check was assessed by physical tests of change in aerobic capacity and strength. Participants were measured on clinical, biological, physiological and neuropsychological tests at pre-, interim and post-treatment.

    Results. Completed treatment protocol for the RCT will be presented. 3 of 4 participants completed the full protocol including testing and the experimental augmented treatment. Participants completed 100% and 80% of CBT and physical exercise content, respectively. The three completers had large improvements on primary outcome and on manipulation checks.

    Conclusion. The testing procedures and experimental augmented treatment appear to be feasible. The preliminary findings indicate that this combined intervention can be efficacious.

  • 16.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Riktlinjer för prevention och behandling vid depression och ångestsyndrom enligt FYSS 20172018Conference paper (Other academic)
  • 17.
    Andersson, Eva
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Oddsson, Kristjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Skador, sjukdomslära samt akut omhändertagande2018In: Idrottens träning, Stockholm: SISU idrottsböcker , 2018, p. 153-181Chapter in book (Other (popular science, discussion, etc.))
    Abstract [sv]

    Ambitionen med detta kapitel är att på ett enkelt, sakligt och inspirerande sätt beskriva akuta sjukdoms- och skadetillstånd (inkl. missbruk) som kan förekomma i samband med fysisk aktivitet, och vilken eller vilka åtgärder som ska sättas in när olyckan är framme. [...]

  • 18.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Institutionen för Neurovetenskap, Karolinska Institutet.
    Startlereflexens betydelse för psykosomatisk smärta. En EMG-studie på barn med stressutlöst återkommande smärta.2018Conference paper (Other academic)
    Abstract [sv]

    Startlereflexens betydelse för psykosomatisk smärta. En EMG-studie på barn med stressutlöst återkommande smärta. 

    Startle-reflexen är en försvarsreflex som beror på upplevelsen av fara vid plötsligt stark stimulering och hänger i hop med flykt- och kampresponsen. I praktiken innebär den att man hajar eller hoppar till. Reflexen aktiveras vid överraskning. Den börjar med en blinkreflex i ögonen och följs på mindre än en tiondels sekund av framåtböjning av huvudet och en nedåtgående böjningsreaktion av kroppen som sträcker sig ned till benen.

    Via muskelaktivitetsregistrering på ett flertal muskler i kroppen sågs under ljudstimuli i studiens smärtgrupp att reflexen utlöstes lättare och tidigare. Den var också kraftigare och varade längre jämfört med en motsvarande frisk kontrollgrupp.

     

  • 19.
    Väisänen, Daniel
    et al.
    Swedish School of Sport and Health Sciences, GIH.
    Ekblom, Maria
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Validity in Ekblom-Bak Test and its Ability to Track Changes in an Elderly Population2018Conference paper (Refereed)
    Abstract [en]

    Background: Maximal oxygen uptake (VO2max) has a high prognostic value for CVD and all cause mortality, however the test is hard to administer and requires a maximal effort, which can be arduous for an elderly population. The submaximal Ekblom-Bak cycle ergometer test (EB test) has shown to be valid in adults, but its applicability in an elderly population is unknown. Aim: The purpose of this study was to validate the submaximal EB test and to examine its ability to detect changes in VO2max in an elderly population. Methods: The sample consisted of 108 elderly participants; aged 65-75 years (54 women, 54 men) with a measured VO2max of 1.42-3.69 L/min. 34 women and 40 men performed a retest (VO2max 1.45-3.59 L/min) after an intervention period. During the intervention, participants performed 30 training sessions over 12 weeks where they cycled for 30 min at 65-75 % of maximal heart rate. On pre- and retests participants completed a submaximal Ekblom-Bak test. Directly after participants completed an individually adjusted VO2max test on a treadmill where VO2 max was measured using indirect calorimetry. Results: For the validation of the EB-test on an elderly population there was a correlation (R) between measured and estimated VO2max of 0.64 for women and 0.47 for men, mean (95% CI) difference was 0.01 (-0.45 - 0.07) for women and -0.05 (-0.11 - 0.07) for men. Standard error of the estimate was 0.17 for women and 0.31 for men. Coefficient of variation was 10 % for women and 11 % for men. When analyzing the ability of the EB test to track change in VO2max after a 12 week training intervention there was a significant (P<0.001) average increase in estimated VO2max of 0.11 L/min for both genders (CI for women 0.06 - 0.16 and for men 0.08 - 0.15), with no change in the measured values. Changes in the estimated values were linked to a decrease of the submaximal HR on both work rates (3.0 bpm and 3.2 bpm on the standard work rate and 5.4 bpm and 6.4 bpm on the higher work rate, for women and men, respectively) Conclusion: Validity of the EB-test in a population between 65-75 years was fairly good but we found larger standard error of the estimate for the men. The higher error for men in contrast to women could be derived from a difference in change of physiological variables that affect VO2max with increasing age. Since there was no change in measured VO2max while there was an improvement in estimated VO2max after the intervention, the EB-test appears to respond to changes in fitness that are not reflected in a VO2max. Grant funding: European Research Council.

  • 20.
    Alfvén, Gösta
    et al.
    Clintec, Karolinska Institutet.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Institutionen för Neurovetenskap, Karolinska Institutet.
    Barn med stressutlöst smärta hade kraftigare startle-reflex2017In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, article id 114:ERZXArticle in journal (Other academic)
    Abstract [sv]

    Återkommande stressutlöst smärta är ett närmast vardagligt fenomen. Avsaknaden av enkla test inom sjukvården för att diagnostisera stressutlöst smärta medför diagnostiska svårigheter och därmed svårigheter med handläggning. Ett grundläggande problem är att förståelse för den patofysiologiska processen bakom långvarig stressutlöst smärta saknas.

    Tidigare studier från samma forskare har visat att barn och tonåringar med långvarig stressutlöst smärta diagnostiserad enligt fastställda kriterier utvecklar ett karakteristiskt mönster av ömma punkter (tender points) i muskler på platser för bland annat huvudvärk, skuldersmärtor och buksmärtor nära naveln. Dessa muskler ingår i startle-reflexen, en neuromuskulär försvarsreaktion som utlöses från en kärna i hjärnstammen. Startle-reflexen startar med en blinkreflex och följs på mindre än en tiondels sekund av framåtböjning av huvudet och en nedstigande böjningsreaktion av kroppen, som sträcker sig ned till benen. Stress kan bland annat via amygdala leda till förstärkt och lättare utlöst startle-reflex.

    Vår hypotes var att startle-reflexen hos individer med stressutlöst smärta är mer lättutlöst och ger ett högre svar än hos friska. I en kontrollerad studie ingick 19 individer i åldern 10–17 år som hade stressutlöst återkommande smärta enligt fastställda kriterier. Gruppen jämfördes med 23 friska i jämförbar ålder, av motsvarande kön och utan smärtbesvär. Under likvärdiga, lugna förhållanden utlöstes startle-reflex vid upprepade starka auditiva signaler på 105 dB via hörlurar, och EMG registrerades från ögonblinkningsmuskeln (orbicularis oculi), tinningmuskel (temporalis), nacknära skuldermuskel (trapezius), stora bröstmuskeln (pectoralis major), bukmuskel (rectus abdominis) samt ryggmuskel (lumbala erector spinae).

    I smärtgruppen var muskelspänningen signifikant förhöjd i ovan nämnda muskler. Startle-reflexen utlöstes också lättare och tidigare, var kraftigare och varade längre. Muskel­aktivitetsgraden efter ljudstimuli visade i smärtgruppen signifikant högre medelamplitud än i kontrollgruppen för alla sex muskler och de åtta upprepade startle-responserna sammantagna. Aktuell forskning om möjliga muskulära och centralnervösa smärtmekanismer presenteras i artikeln.

    För första gången har ökad muskelspänning och förstärkt startle-reaktion påvisats med EMG hos barn/ungdomar med återkommande stressutlöst smärta i ett mönster som sammanfaller med mönstret av ömma punkter och smärtlokalisation. Vår förhoppning är att dessa fynd ska stimulera till fortsatt forskning och förbättra klinisk praxis.

    Alfvén, G, Grillner, S, Andersson E. Eur J Pain. Epub 4 maj 2017. doi: 10.1002/ejp.1057

  • 21.
    Alfvén, G
    et al.
    Karolinska institutet.
    Grillner, S
    Karolinska institutet.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet.
    Children with chronic stress-induced recurrent muscle pain have enhanced startle reaction.2017In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 21, no 9, p. 1561-1570Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Children with recurrent pain of negative chronic stress origin from different locations have a characteristic pattern of tender points in the temporal, trapezoid, great pectoral and abdominal muscles. We tested the hypothesis that the startle reaction is activated in these children and that some of the startle-activated muscles are related to the tender point pattern and the recurrent pain.

    METHODS: In children/adolescents, aged 10-17 years, 19 with recurrent psychosomatic pain (PAIN) and 23 controls (CON) we measured and analysed resting activity and acoustic startle response with electromyography (EMG) for the muscles involved in the pattern of tender points and also the lumbar erector spinae.

    RESULTS: The PAIN group showed higher resting activity and higher acoustic startle response values than the CON group for all six muscles together regarding the mean amplitude in the initial 200 ms, and during the burst of activity, and longer burst duration and shorter burst latency. For PAIN versus CON, all separate muscles showed generally higher values of EMG amplitudes and burst durations, and shorter latencies for the burst onset in all measures; with significance or strong trends for several parameters and muscles.

    CONCLUSION: For the first time in children with recurrent psychosomatic pain, increased resting activity and potentiated startle response were demonstrated in the muscles involved in the stress tender point pattern.

    SIGNIFICANCE: This study demonstrates in adolescents how recurrent pain of negative stress origin from the head, stomach, back and chest is related to increased startle reaction and increased muscular tension in these regions. This study contributes to the understanding of the mechanisms underlying the global burden of recurrent pain.

  • 22.
    Martinsen, Egil W.
    et al.
    Oslo universitetssjukhus.
    Hovland, Anders
    Universitet i Bergen.
    Kjellman, Bengt
    Karolinska insitutet.
    Taube, Jill
    Landstinget i Värmland.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Karolinska institutet.
    Fysisk aktivitet vid depression: Forskning pågår2017In: Fysioterapi, ISSN 1653-5804, no 5, p. 34-39Article in journal (Other academic)
    Abstract [sv]

    Vi har nöjet att publicera kapitel 2.8 Fysisk aktivitet vid depression ur  Fysisk aktivitet i sjukdomsprevention och sjukdomsbehandling, FYSS 2017  med tillstånd av Yrkesföreningar för Fysisk Aktivitet (YFA). Detta kapitel samt  ytterligare drygt 30 kapitel ur FYSS 2017 kan laddas ner från www.fyss.se.  Samtliga 53 kapitel är samlade i boken FYSS 2017 utgiven av Läkartidningen förlag AB.

    SAMMANFATTANDE REKOMMENDATION •  Personer med depression bör rekommenderas aerob eller muskelstärkande fysisk aktivitet för att minska depressiva symtom. Måttligt starkt vetenskapligt underlag (evidensstyrka +++). •  Fysisk aktivitet reducerar depressiva symtom i liknande grad som antidepressiva läkemedel eller KBT vid lindrig och måttlig depression. Måttligt starkt vetenskapligt underlag (evidensstyrka +++). •  Om enbart muskelstärkande fysisk aktivitet väljs i syfte att behandla depression, bör den kompletteras med aerob fysisk aktivitet för att minska risken för kardiovaskulär sjukdom, eftersom denna risk är förhöjd vid depression.

  • 23.
    Andersson, Eva A
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology. Karolinska institutet.
    Frank, Per
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology. Karolinska institutet.
    Pontén, Marjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Ekblom, Maria
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology. Karolinska institutet.
    Moberg, Marcus
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Sahlin, Kent
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People.2017In: Journal of Visualized Experiments, ISSN 1940-087X, E-ISSN 1940-087X, no 125Article in journal (Refereed)
    Abstract [en]

    This protocol describes the simultaneous use of a broad span of methods to examine muscle aerobic capacity, glucose tolerance, strength, and power in elderly people performing short-term resistance training (RET). Supervised progressive resistance training for 1 h three times a week over 8 weeks was performed by RET participants (71±1 years, range 65-80). Compared to a control group without training, the RET showed improvements on the measures used to indicate strength, power, glucose tolerance, and several parameters of muscle aerobic capacity. Strength training was performed in a gym with only robust fitness equipment. An isokinetic dynamometer for knee extensor strength permitted the measurement of concentric, eccentric, and static strength, which increased for the RET group (8-12% post- versus pre-test). The power (rate of force development, RFD) at the initial 0-30 ms also showed an increase for the RET group (52%). A glucose tolerance test with frequent blood glucose measurements showed improvements only for the RET group in terms of blood glucose values after 2 h (14%) and the area under the curve (21%). The blood lipid profile also improved (8%). From muscle biopsy samples prepared using histochemistry, the amount of fiber type IIa increased, and a trend towards a decrease in IIx in the RET group reflected a change to a more oxidative profile in terms of fiber composition. Western blot (to determine the protein content related to the signaling for muscle protein synthesis) showed a rise of 69% in both Akt and mTOR in the RET group; this also showed an increase in mitochondrial proteins for OXPHOS complex II and citrate synthase (both ~30%) and for complex IV (90%), in only the RET group. We demonstrate that this type of progressive resistance training offers various improvements (e.g., strength, power, aerobic capacity, glucose tolerance, and plasma lipid profile).

  • 24.
    Taube, Jill
    et al.
    Själ och Kropp, Stockholm.
    Jonsdottir,, Ingibjörg H
    Göteborgs universitet.
    Kjellman,, Bengt
    Uppsala Akademiska sjukhuset.
    Hovland, Anders
    Universitetet i Bergen; Solli Distriktspsykiatriske Senter (DPS), Nesttun, Norge.
    Sundberg, Carl Johan
    Inst. för fysiologi och farmakologi, Karolinska Institutet.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Martinsen, Egil W
    Universitetet i Oslo; överläkare, Kliniken för psykisk hälsa och beroende, Oslo universitetssjukhus.
    Levnadsvanor bör integreras i de nya riktlinjerna2017In: Dagens medicin, article id 23 marsArticle in journal (Other (popular science, discussion, etc.))
    Abstract [sv]

    ”Levnadsvanor bör integreras i de nya riktlinjerna”

    Vi är kritiska till att Socialstyrelsens olika riktlinjer tillåts krocka med varandra, skriver sju debattörer. 

    Publicerad: 2017-03-23 07:00 Skriven av: Jill Taube, Ingibjörg H Jonsdottir, Bengt Kjellman, Anders Hovland, Carl Johan Sundberg, Eva Andersson och Egil W Martinsen

    Detta är opinionsmaterial. Åsikterna som förs fram här är upphovsmannens egna.

     

    Fysisk aktivitet som prevention och behandling har varit en naturlig del av hälso- och sjuk­vården sedan början av 2000-talet. År 2011 breddade Socialstyrelsen detta med riktlinjer för sjukdoms­förebyggande metoder där tobaksbruk, riskbruk av alkohol, ohälsosamma matvanor och otillräcklig fysisk aktivitet inbegreps. Personer med psykisk ohälsa har här prioriterats av flera skäl, då man löper en stor risk för kroppslig ohälsa och förkortat liv.

    Nu uppdaterar Social­styrelsen riktlinjer om behandling av depression och ångest och uppmärksammar samsjuklighet som hjärt-kärlsjukdom och diabetes, men nämner inte levnadsvanor som en nödvändig del i omhändertagandet, vilket är olyckligt.

    Betydelsen av råd om fysisk aktivitet som en del av behandlingen av patienter med depression, framkommer tydligt i andra länder såsom Storbritannien med expertmyndigheten Nice. Här ses fysisk aktivitet som en viktig bas, oberoende av övrig behandling.

    “Här ses fysisk aktivitet som en viktig bas, oberoende av övrig behandling.”

    Riktlinjer från 2010 gav stöd för fysisk aktivitet som behandling av mild till måttlig depression. I de nya riktlinjerna som publicerades i december 2016, är detta i stort sett borta.

    Vi menar att det är kontra­produktivt att Social­styrelsen inom ramen för ett riktlinjearbete inte ser till övrigt arbete inom myndigheten.

    Socialstyrelsens föreslagna riktlinjer krockar med vad vi har redovisat i den helt nyligen upp­daterade versionen av Fysisk aktivitet i sjukdomsprevention och sjukdomsbehandling, Fyss, avseende behandling av depression. I vårt arbete har ett stort antal vetenskapliga artiklar och meta-analyser granskats. I Social­styrelsens underlag redovisas endast sex vetenskapliga referenser.

    Vi är inte heller ensamma om att rikta kritik mot de nya rikt­linjerna. Skarp kritik framfördes också av tre sakkunniga inom psykoterapiområdet som själva varit en del av riktlinjearbetet. Där beskriver man en icke-transparent arbetsorganisation som i mycket hög grad har präglats av partiskhet till förmån för vissa insatser. Personer med kunskap om annat än KBT och läke­medels­behand­ling var i extrem minoritet, vilket påverkade omröstnings­förfarandet. Vi saknar insikt om hur denna process gått till, men blir oroade över den kritik som framförts.

    Sammanfattningsvis är vi kritiska till att Socialstyrelsens olika riktlinjer tillåts krocka med varandra. Socialstyrelsen bör ta ett större grepp och även integrera råd om levnadsvanor i de föreslagna nya riktlinjerna, gärna i samråd med andra myndigheter. Vi ifrågasätter också prioriteringsgruppens slutsats av evidensen för fysisk aktivitet som behandlingsalternativ för mild till måttlig depression.

    Vi har framfört dessa syn­punkter direkt till Social­styrelsen, i ett detaljerat remissvar. Vi hoppas att vårt inlägg ska upp­fattas som ett sätt att fortsätta den konstruktiva dialog vi redan har med myndigheten och därmed sakfrågan framåt. 

    Jill Taube, specialistläkare i psykiatri, Ingibjörg H Jonsdottir, professor, institutionen för kost och idrottsvetenskap, Göteborgs universitet, Bengt Kjellman, docent, specialist­läkare i psykiatri, Karolinska institutet och Akademiska sjukhuset i Uppsala, Anders Hovland, försteamanuens, psykolog, Solli distriktspsykiatriske senter och institutionen for klinisk psykologi, Universitetet i Bergen, Carl Johan Sundberg, professor, läkare, institutionen för fysiologi och farmakologi, Karolinska institutet, Stockholm, Eva Andersson, docent, läkare, idrottslärare, Gymnastik- och idrottshögskolan och institutionen för neurovetenskap, Karolinska institutet, Stockholm, Egil W Martinsen, professor, specialistläkare i psykiatri, Universitetssjukhuset i Oslo.

     

    https://www.dagensmedicin.se/artiklar/2017/03/23/levnadsvanor-bor-integreras-i-de-nya-riktlinjerna/

     

  • 25.
    Olsson, Sven Johan Gustav
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Börjesson, Mats
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group. Department of Medicine, Unit of Cardiology, Karolinska University Hospital, Solna.
    Kallings, Lena
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Categorical answer modes provides superior validity to open answers when asking for level of physical activity: A cross-sectional study2016In: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 44, no 1, p. 70-76, article id 1403494815602830Article in journal (Refereed)
    Abstract [en]

    AIMS:

    Physical activity (PA) used as prevention and treatment of disease has created a need for effective tools for measuring patients' PA level. Our aim was therefore to assess the validity of two PA questions and their three associated answer modes.

    METHODS:

    Data on PA according to the PA questions and Actigraph GT3X+ accelerometers, aerobic fitness (VO2max), cardiovascular biomarkers, and self-rated general health were collected in 365 Swedish adults (21-66 years). The PA questions ask about weekly PA via categories (Categorical), an open-ended answer (Open), or specified day by day (Table).

    RESULTS:

    The Categorical mode, compared with the Open mode, correlated (Spearman's rho) significantly more strongly (p<0.05) with accelerometer PA (0.31 vs. 0.18) and VO2max (0.27 vs. 0.06), and the level of BMI (-0.20 vs. -0.02), waist circumference (-0.22 vs. -0.03), diastolic blood pressure (-0.16 vs. 0.08), glucose (-0.18 vs. 0.04), triglycerides (-0.31 vs. -0.07), and general health (0.35 vs. 0.19). The validity of the Categorical and Table modes were similar regarding VO2max and accelerometry, but the Categorical mode exhibited more significant and stronger correlations with cardiovascular biomarkers. The capacity of the PA questions to identify insufficiently physically active individuals ranged from 0.57 to 0.76 for sensitivity and from 0.47 to 0.79 for specificity.

    CONCLUSIONS:

    The Categorical mode exhibits the strongest validity and Open mode the weakest. The PA questions may be used on a population level, or as a tool for determining patents' appropriateness for treatment.

  • 26.
    Martinsen, Egil W
    et al.
    Oslo universitetssjukhus.
    Hovland, Anders
    Universitetet i Bergen.
    Kjellman, Bengt
    Karolinska institutet.
    Taube, Jill
    Landstinget i Värmland.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Fysisk aktivitet vid depression2016In: FYSS 2017: fysisk aktivitet i sjukdomsprevention och sjukdomsbehandling, Läkartidningen förlag , 2016, p. 362-370Chapter in book (Other academic)
    Abstract [sv]

    Sammanfattande rekommendation

    Personer med depression bör rekommenderas aerob eller muskelstärkande fysisk aktivitet för att minska depressiva symtom, måttligt starkt vetenskapligt underlag (evidensstyrka +++), och förbättra livskvalitet, begränsat vetenskapligt underlag (evidensstyrka ++).

    Vid lindrig eller måttlig depression reducerar fysisk aktivitet depressiva symtom i liknande grad som antidepressiva läkemedel eller kognitiv beteendeterapi (KBT). Måttligt starkt vetenskapligt underlag (evidensstyrka +++).

    Om enbart muskelstärkande fysisk aktivitet väljs i syfte att behandla depression, bör den kompletteras med aerob fysisk aktivitet för att minska risken för hjärt-kärlsjukdom, eftersom denna risk är förhöjd vid depression.

  • 27.
    Hovland, Anders
    et al.
    Universitet i Bergen.
    Martinsen, Egil W.
    Oslo universitetssykehus.
    Taube, Jill
    Landstinget i Värmland.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Kjellman, Bengt
    Karolinska institutet.
    Fysisk aktivitet vid ångestsyndrom2016In: FYSS 2017: fysisk aktivitet i sjukdomsprevention och sjukdomsbehandling, Läkartidningen förlag , 2016, p. 632-643Chapter in book (Other academic)
    Abstract [sv]

    Sammanfattande rekommendation

    Personer med panikångest bör rekommenderas aerob fysisk aktivitet för att minska ångest. Måttligt starkt vetenskapligt underlag (evidensstyrka +++).

    Ett enstaka aerobt träningspass på hög intensitet minskar risken att utlösa panikångest. Måttligt starkt vetenskapligt underlag (evidensstyrka +++).

    Fysisk aktivitet kan användas som kompletterande behandling vid all form av ångest, då det finns grund för att förvänta en viss symtomreduktion både akut och på längre sikt.

    Den fysiska aktiviteten bör utformas och individanpassas av medicinskt utbildad personal i samråd med individen.

    Personer med ångest, oavsett typ, bör även rekommenderas muskelstärkande fysisk aktivitet enligt de allmänna rekommendationerna om fysisk aktivitet.

  • 28.
    Andersson, Eva
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Hovland, Anders
    Kjellman, Bengt
    Taube, Jill
    Martinsen, Egil W.
    Fysisk aktivitet är lika bra som läkemedel eller samtalsterapi vid depression2016In: Idrottsmedicin, ISSN 2001-3302, Vol. 35, no 1, p. 4-7Article in journal (Other academic)
  • 29.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control. Institutionen för Neurovetenskap, Karolinska Institutet.
    Fysisk aktivitet är lika bra som samtalsterapi eller läkemedel vid mild till måttlig depression2016In: / [ed] Svensk förening för fysisk aktivitet och Idrottsmedicin, SFAIM, 2016Conference paper (Other academic)
  • 30.
    Sirivåg, K
    et al.
    Universitetet i Bergen; Solli Distriktspsykiatriske Senter (DPS), Nesttun, Norge.
    Stavestrand, SH
    Sjøbø, T
    Endal, T
    Nordhus, IH
    Pallesen, S
    Nordahl, H
    Pallesen, S
    Nordahl, H
    Mohlman, J
    Specht, K
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Hammar, Å
    Halmøy, A
    Harkestad, N
    Hjelmervik, H
    Martinsen, E
    Thayer, J
    Harvey, A
    Hovland, A
    Universitetet i Bergen; Solli Distriktspsykiatriske Senter (DPS), Nesttun, Norge.
    Physical EXercise Augmented COGnitive Behaviour Therapy for Older Adults with Generalised Anxiety Disorder (PEXACOG)2016Conference paper (Refereed)
    Abstract [en]

    Generalised anxiety disorder (GAD) is the most prevalent severe anxiety disorder among older adults. The disorder has a pervasive influence on the lives of those affected, and is a risk factor for other severe disorders such as depression, dementia and coronary heart disease. Cognitive behaviour therapy (CBT) is the treatment of choice for this disorder, but older adults have shown reduced effect of treatment compared to working age adults. Physical exercise has been suggested as intervention to improve the effects of treatment for GAD, via its demonstrated positive effect on cognitive functioning, increased plasticity in the brain, and increased availability of neurotrophins important for extinction of fear associations. The aim of the current research project is to investigate whether augmenting CBT with physical exercise will lead to improved effects of CBT on GAD in older adults in a randomized controlled trial (RCT). Participants between 60-75 years of age with a primary diagnosis of GAD will be randomised to one of two treatment conditions. The effects of treatment will be assessed on outcome measures, biological, physiological and cognitive measures at pre- interim-, and post-treatment, and follow-up assessments at 6- and 12-months post intervention. Participants in both groups will receive five weeks of pre-treatment intervention consisting of either physical exercise or weekly telephone contact. Participants thereafter receive either ten weeks of manualised CBT for GAD combined with manualised physical exercise or ten weeks of manualised CBT for GAD combined with weekly telephone contact. We expect that the treatment effect of the physical exercise augmented CBT will be greater than that of CBT combined with weekly telephone contact, as measured by a reduction in GAD symptoms on the Penn State Worry Questionnaire and in the proportion of remitted patients. The study also aims to determining the possible beneficial and augmenting properties of physical exercise in combination with CBT, and our understanding of clinical characteristics of GAD and mechanisms involved in treatment effect. Treatment rationale, procedures and protocols will be presented in detail together with preliminary results from the initial feasibility study comprises eight participants.

  • 31.
    da Silva, Julio Cézar Lima
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Tarassova, Olga
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Ekblom, Maria
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Rönquist, Gustaf
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Arndt, Anton
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Quadriceps and hamstring muscle activity during cycling as measured with intramuscular electromyography.2016In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 116, no 9, p. 1807-1817Article in journal (Refereed)
    Abstract [en]

    PURPOSE: The aim of this study was to describe thigh muscle activation during cycling using intramuscular electromyographic recordings of eight thigh muscles, including the biceps femoris short head (BFS) and the vastus intermedius (Vint).

    METHODS: Nine experienced cyclists performed an incremental test (start at 170 W and increased by 20 W every 2 min) on a bicycle ergometer either for a maximum of 20 min or to fatigue. Intramuscular electromyography (EMG) of eight muscles and kinematic data of the right lower limb were recorded during the last 20 s in the second workload (190 W). EMG data were normalized to the peak activity occurring during this workload. Statistical significance was assumed at p ≤ 0.05.

    RESULTS: The vastii showed a greater activation during the 1st quadrant compared to other quadrants. The rectus femoris (RF) showed a similar activation, but with two bursts in the 1st and 4th quadrants in three subjects. This behavior may be explained by the bi-articular function during the cycling movement. Both the BFS and Vint were activated longer than, but in synergy with their respective agonistic superficial muscles.

    CONCLUSION: Intramuscular EMG was used to verify muscle activation during cycling. The activation pattern of deep muscles (Vint and BFS) could, therefore, be described and compared to that of the more superficial muscles. The complex coordination of quadriceps and hamstring muscles during cycling was described in detail.

  • 32.
    Frank, Per
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Pontén, Marjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Ekblom, Maria
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Sahlin, Kent
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Strength training improves muscle aerobic capacity and glucose tolerance in elderly2016In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 26, no 7, p. 764-773Article in journal (Refereed)
    Abstract [en]

    The primary aim of this study was to investigate the effect of short-term resistance training (RET) on mitochondrial protein content and glucose tolerance in elderly. Elderly women and men (age 71 ± 1, mean ± SEM) were assigned to a group performing 8 weeks of resistance training (RET, n = 12) or no training (CON, n = 9). The RET group increased in (i) knee extensor strength (concentric +11 ± 3%, eccentric +8 ± 3% and static +12 ± 3%), (ii) initial (0-30 ms) rate of force development (+52 ± 26%) and (iii) contents of proteins related to signaling of muscle protein synthesis (Akt +69 ± 20 and mammalian target of rapamycin +69 ± 32%). Muscle fiber type composition changed to a more oxidative profile in RET with increased amount of type IIa fibers (+26.9 ± 6.8%) and a trend for decreased amount of type IIx fibers (-16.4 ± 18.2%, P = 0.068). Mitochondrial proteins (OXPHOS complex II, IV, and citrate synthase) increased in RET by +30 ± 11%, +99 ± 31% and +29 ± 8%, respectively. RET resulted in improved oral glucose tolerance measured as reduced area under curve for glucose (-21 ± 26%) and reduced plasma glucose 2 h post-glucose intake (-14 ± 5%). In CON parameters were unchanged or impaired. In conclusion, short-term resistance training in elderly not only improves muscular strength, but results in robust increases in several parameters related to muscle aerobic capacity.

  • 33.
    Andersson, Eva
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Hovland, Anders
    Universitetet i Bergen, Solli Distriktspsykiatriske Senter, Nesttun, Norge.
    Kjellman, Bengt
    Psykiatrikliniken, Uppsala Akademiska sjukhuset.
    Taube, Jill
    Själ och Kropp, Stockholm.
    Martinsen, Egil
    Universitetet i Oslo, Kliniken för psykisk hälsa och beroende, Oslo universitetssjukhus.
    Fysisk aktivitet lika bra som KBT eller läkemedel vid depression2015In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, no 47, p. 2102-2104Article in journal (Refereed)
    Abstract [sv]

    Fyisk aktivitet har dokumenterad effekt vid depression. Effekten är lika god som effekten av antidepressiva läkemedel eller kognitiv beteendeterapi (KBT) vid lindrig till måttlig depression. Dessutom är fysisk aktivitet i stort sett biverkningsfritt.

  • 34.
    Martinsen, Egil
    et al.
    Oslo universitetssjukhus.
    Hovland, Anders
    Universitet i Bergen.
    Kjellman, Bengt
    Psykiatriska öpenvårdsmottagningen Huddinge.
    Taube, Jill
    Landstinget i Värmland.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Fysisk aktivitet vid depression2015In: FYSS 2015, Stockholm: Yrkesföreningen för fysisk aktivitet , 2015, p. 1-12Chapter in book (Other (popular science, discussion, etc.))
    Abstract [sv]

    Fysisk aktivitet kan förebygga insjuknande och återsjuknande i depression.

    Enbart fysisk träning har klart vetenskapligt stöd när det gäller behandling vid lindrig och måttlig depression.

    Fysisk träning som tillägg till sedvanlig behandling i form av samtal och mediciner ger en förstärkt effekt.

    Fysisk aktivitet har utöver effekt på depression också en gynnsam effekt på vanliga komorbida tillstånd, som typ 2-diabetes och hjärt-kärlsjukdom.

    Personer med depression bör rekommenderas fysisk aktivitet som tillägg till samtalsterapi och läkemedel.

  • 35.
    Andersson, Eva
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Oddsson, Kristjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Skador & sjukdomar: Akut omhändertagande inom idrotten2015Book (Other (popular science, discussion, etc.))
    Abstract [sv]

    Olika skador i rörelseapparaten och hur man agerar vid akuta sjukdoms- eller olycksfall ingår. Den första delen innehåller bland annat en genomgång av skadetyper kroppsdel för kroppsdel, samt ett avsnitt om tejpning. I den andra delen har det gjorts ett urval av olika akuta sjukdoms- och skadetillstånd som kan förekomma i samband med fysisk aktivitet. På ett enkelt och sakligt sätt beskrivs skador och sjukdomar som av olika anledningar drabbar fysiskt aktiva personer och vilken/vilka åtgärder som ska sättas in när olyckan är framme. Du får veta vad du kan göra själv och vad som måste behandlas av läkare.

  • 36.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences. Institutionen för Neurovetenskap, Karolinska Institutet.
    Äldre blir starkare i GIHs hälsoprojekt2015In: Äldre i centrum : tidskrift för aktuell äldreforskning, ISSN 1653-3585, no 4, p. 2p. 24-25Article in journal (Other (popular science, discussion, etc.))
    Abstract [sv]

    Ett lyckosamt projekt för seniorer 65 år och äldre har sedan 2005 pågått på Gymnastik- och idrottshögskolan, GIH. Deltagarna tränar kostnadsfritt och utför hälsotester med GIH:s studenter på hälsopedagogprogrammet. Syftet är att utveckla metoder som kan bidra till ökad fysisk aktivitet och fysisk kapacitet som ett led i sänkta vård- och omsorgskostnader och ökat välmående hos de äldre.

  • 37. Andersson, B
    et al.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Arnell, J
    Bergenfeldt, T
    Forsberg, A
    Amer-Wåhlin, I
    Ljung, B
    Magnegård, T
    Nilsson, Johnny
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Olausson, K
    Olsson Sundelin, T
    Sarac, L
    Sandberg, H
    Ökad fysisk aktivitet viktigt för att bromsa sjukfrånvaron2015In: Dagens nyheter, DN, article id 27 novArticle in journal (Other (popular science, discussion, etc.))
    Abstract [sv]

    Försäkringskassans rapport (DN Debatt 27/11 2015) visar att sjukfrånvaron fortsätter att öka och lovar att kraftsamla i sjukförsäkringshandläggningen. Men, precis som Försäkringskassan skriver, kommer det inte att räcka för att nå regeringens mål. Regeringens åtgärdsprograms program i sju punkter för att minska sjukfrånvaron saknar en viktig komponent. Det måste kompletteras med fysisk aktivitet som ett åttonde område för att trenden ska kunna brytas, skriver 13 debattörer.

  • 38.
    Andersson, Eva
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Kallings, Lena
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Hultgren, Staffan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Kraepelien Strid, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Hälsopedagogprogrammet2014In: Från Kungl. Gymnastiska Centralinstitutet till Gymnastik- och idrottshögskolan: en betraktelse av de senaste 25 åren som del av en 200-årig historia / [ed] Suzanne Lundvall, Stockholm: Gymnastik- och idrottshögskolan, GIH , 2014, p. 108-116Chapter in book (Other (popular science, discussion, etc.))
  • 39.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Physical fitness: I. Muscle strength II. Aerobic fitness: Muscle oxygen uptake and heart rate2014In: Women and sport, Stockholm: SISU idrottsböcker , 2014Chapter in book (Other academic)
    Abstract [en]

    Improved muscle strength and aerobic fitness are of great importance in many sports and are also associated with increased life expectancy and a reduced incidence of a number of diseases. In this chapter, we will discuss some of the factors that influence muscle strength and aerobic fitness, including sex-related factors. The way physical fitness is measured is also important when making comparisons. An increased understanding of the assessment of strength and aerobic fitness may inspire fruitful improvements in practical test and training programs in various sport and health contexts.

  • 40.
    Frank, Per
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Research group for Mitokondriell funktion och metabolisk kontroll.
    Katz, Abram
    Karolinska Institutet.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Research group for Mitokondriell funktion och metabolisk kontroll.
    Sahlin, Kent
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Research group for Mitokondriell funktion och metabolisk kontroll.
    Acute exercise reverses starvation-mediated insulin resistance in humans.2013In: American Journal of Physiology. Endocrinology and Metabolism, ISSN 0193-1849, E-ISSN 1522-1555, Vol. 304, no 4, p. E436-43Article in journal (Refereed)
    Abstract [en]

    Within 2-3 days of starvation, pronounced insulin resistance develops, possibly mediated by increased lipid load. Here, we show that one exercise bout increases mitochondrial fatty acid (FA) oxidation and reverses starvation-induced insulin resistance. Nine healthy subjects underwent 75-h starvation on two occasions: with no exercise (NE) or with one exercise session at the end of the starvation period (EX). Muscle biopsies were analyzed for mitochondrial function, contents of glycogen, and phosphorylation of regulatory proteins. Glucose tolerance and insulin sensitivity, measured with an intravenous glucose tolerance test (IVGTT), were impaired after starvation, but in EX the response was attenuated or abolished. Glycogen stores were reduced, and plasma FA was increased in both conditions, with a more pronounced effect in EX. After starvation, mitochondrial respiration decreased with complex I substrate (NE and EX), but in EX there was an increased respiration with complex I + II substrate. EX altered regulatory proteins associated with increases in glucose disposal (decreased phosphorylation of glycogen synthase), glucose transport (increased phosphorylation of Akt substrate of 160 kDa), and FA oxidation (increased phosphorylation of acetyl-CoA carboxylase). In conclusion, exercise reversed starvation-induced insulin resistance and was accompanied by reduced glycogen stores, increased lipid oxidation capacity, and activation of signaling proteins involved in glucose transport and FA metabolism.

  • 41.
    Andersson, Eva A.
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Rönquist, Gustaf
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Oddsson, Kristjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Nilsson, Johnny
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Äldre blir starkare av Hälsoprojektet2013In: Svensk Idrottsforskning: Organ för Centrum för Idrottsforskning, ISSN 1103-4629, Vol. 22, no 1, p. 25-27Article in journal (Other academic)
    Abstract [sv]

    En god kondition och styrka har samband med förbättrad hälsa, minskad förekomst av flera folksjukdomar samt ökad livslängd. Fysiologiska tester kan vara stimulerande för äldre att följa utvecklingen av sin fysiska kapacitet och för olika aktörer som vill göra hälsoutvärderingar.

  • 42.
    Berthelson, Per
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Research group for Mitokondriell funktion och metabolisk kontroll.
    Katz, Abram
    Institutionen för Fysiologi och Farmakologi, Karolinska Instititutet.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH.
    Sahlin, Kent
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Research group for Mitokondriell funktion och metabolisk kontroll.
    Acute exercise and starvation induced insulin resistance2012In: Medicine & Science In Sports & Exercise, 2012, S498 Vol. 44 No. 5 Supplement. 2661., 2012, p. 2661-Conference paper (Other academic)
    Abstract [en]

    It is well known that starvation causes insulin resistance. The mechanism is unclear but may relate disturbances in lipid metabolism i.e. incomplete mitochondrial FA oxidation and/or accumulation of lipid intermediates. Exercise results in increased substrate oxidation and may thus remove interfering lipid metabolites and reverse starvation-induced insulin resistance. However, the effect of acute exercise and starvation on insulin sensitivity is not known.

    Purpose: The aim of this study was to investigate the effect of exercise on starvation-induced insulin resistance and to elucidate potential mechanisms.

    Methods: Nine healthy lean subjects underwent 84h starvation on two occasions separated by at least 2 weeks. The starvation period was followed by either exercise (EX; 5x10 min intervals with 2-4 min rest, starting at 70 %VO2 max) or an equal period of rest (NE). Before and after the starvation period (3h after exercise/rest) subjects were investigated with muscle biopsies, bloo samples and an intravenous glucose tolerance test. Muscle samples were used for measurement of mitochondrial respiration in permeabilized muscle fibers (Oroboros oxygraph), glycogen content and activation of signaling proteins.

    Results: Insulin sensitivity was significantly higher in the EX group compared to the NE group (p<0.05). After starvation mitochondrial respiration was lower in both groups with complex I substrates whereas respiration with complex I+II substrates was higher in EX (p<0.05 vs. basal and NE). Muscle glycogen was decreased to 73% (NE) and 31% (EX) of the basal values. The EX group had a significant increased activation of AS160. Plasma FA increased 3-4 fold to 1.39±0.32(NE) and 1.80±0.49 (EX) (mmol/l) after starvation and plasma beta-hydroxybutyrate increased about 50-fold to 6.43±2.01(NE) and 7.12±1.59 (EX)(mmol/l).

    Conclusion: Acute exercise reverses starvation-induced insulin resistance. Plasma FA and BOH were increased to similar extent after NE and EX and cannot explain the changes in insulin sensitivity. However, an increased substrate oxidation together with the observed increased capacity for mitochondrial FA oxidation after EX may be involved in the activation of AS160 and the reversal of starvation-induced insulin resistance.

  • 43.
    Frank, Per
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Research group for Mitokondriell funktion och metabolisk kontroll.
    Katz, Abram
    Institutionen för Fysiologi och Farmakologi, Karolinska Institutet.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH.
    Sahlin, Kent
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Research group for Mitokondriell funktion och metabolisk kontroll.
    Acute exercise during starvation improves insulin sensitivity and increases mitochondrial FA oxidation2012Conference paper (Other academic)
    Abstract [en]

    Aim: To investigate if exercise can reverse starvation-induced insulin resistance and to elucidate the mechanism. Methods: Nine subjects underwent 87 h of starvation with (EX) or without (NE) one exercise session at the end. Before and after starvation (3 h post-exercise) subjects underwent an intravenous glucose tolerance test and muscle biopsy. Results: Insulin sensitivity decreased after starvation (NE) but increased after exercise (EX). Glycogen stores were reduced and plasma FA and β-Hydroxybutyrate increased in both conditions. Mitochondrial respiration with FA substrate increased in EX but was unchanged in NE. RCR and mitochondrial ROS production decreased in both conditions. Phosphorylation of Acetyl-CoA carboxylase (ACC) and Akt substrate of 160 kDA (AS160) proteins increased in EX. Conclusion: Exercise improves starvation induced insulin resistance, probably by increased mitochondrial FA oxidation, reduced glycogen stores and alterations in signaling proteins involved in glucose uptake and FA metabolism.

  • 44. Danielsson, Evelina
    et al.
    Oddsson, Kristjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Nilsson, Johnny
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Fredriksson, Mårten
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Ovendal, Alexander
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Wahlgren, Lina
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Hultgren, Staffan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Hälsoprojekt med ledarledd fysisk aktivitet för äldre2012Conference paper (Other academic)
    Abstract [sv]

    Bakgrund och syfte. Syftet med hälsoprojektet under 8-12 veckor för äldre är att ge ledarledd fysisk aktivitet 2 gånger/vecka samt att utvärdera upplevd hälsa, förändring av livsstilssvanor samt fysisk kapacitet. Hälsoprojektet är ett fortlöpande samarbete mellan Solna stad och Gymnastik- och idrottshögskolan (GIH) och utförs under vårterminerna sedan ett flertal år.

    Metod. Individerna anmäler sitt deltagande själva. Det kostnadsfria hälsoprojektet utförs inom undervisningen i Folkhälsa i regi av GIH-studenter under handledning av verksamhetschefen i Solna stad och lärare/läkare på GIH. Den ledarledda fysiska aktiviteten utgörs primärt av stavgång, motionsgymnastik, vattengymnastik samt styrketräning. Initialt och i slutet av perioden besvarar deltagarna en hälsoenkät angående upplevd hälsa och livsstilsvanor om fysisk aktivitet, kost, sömn, rökning och alkohol samt utför några olika fysiologiska tester i samband med ett hälsosamtal.

    Resultat. Exempel på sammanställda resultat ges här för de 117 äldre som fullföljde hela projektet under en vårtermin (för kvinnorna var antalet samt medelvärden för ålder och BMI 99, 74år och 26 respektive för männen 18, 73år och 25). Efter avslutat projekt sågs för gruppen som helhet generellt en signifikant förbättrad upplevd fysisk och mental hälsa, kondition och styrka i buk-, ben- och armmuskulatur. För kvinnorna observerades även en ökad balansförmåga och uthållighet i ryggmusklerna. Enkätfrågorna angående fysiska aktivitetsvanor och stillasittande visade på, efter avslutat projekt, en förändring till en mer aktiv livsstil.

    Slutsats/Diskussion. Således kan utvärderade 8-12 veckors hälsoprojekt med ledarledd fysisk aktivitet för äldre bidra till förbättrad upplevd hälsa, ökade fysiska aktivitetsvanor, minskat stillasittande och bättre fysiska kapaciteter såsom kondition, styrka och balans som är positivt korrelerade till ökad livslängd och minskad förekomst av en mängd olika folksjukdomar och skador. Fler projekt och studier behövs framöver med ytterligare uppföljningar, jämförelser och för att vidareutveckla olika fysiologiska tester och andra hälsoparametrar som kan ha positiva samband med ökad hälsa.

  • 45.
    Wecke, Liliane
    et al.
    Dep of Cardiology, Karolinska sjukhuset & Karolinska Institutet.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Nilsson, Johnny
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Lundahl, Gunilla
    Bergfeldt, Lennart
    Younger People Show More Changes in Repolarization with Exercise2012Conference paper (Other academic)
    Abstract [en]

    Background:

    Cardiac repolarization is a complex phenomenon that depends on heart rate (HR), autonomic nervous system (ANS) activity, age, gender and diseases/pathological conditions etc. Cardiovascular events in LQT1 mutation carriers are also typically related to age, gender, and QT interval, and are triggered by physical exercise. We studied the repolarization response to heavy exercise in healthy subjects.

    Material and methods:

    Vectorcardiography (VCG) was recorded with the Coronet II system (Ortivus AB, Danderyd, Sweden) using the Frank orthogonal leads (X, Y and Z) at supine rest before and after a maximal cycle ergometer test in 42 healthy subjects. They were of different age and gender, 21 old (64-79 years) and 21 young (20-32 years), 23 were women and 19 men. Maximum T-vector amplitude and direction were assessed as well as T-area, QTc-interval and other VCG parameters.

    Results:

    At baseline most parameters differed between old and young subjects, but only QRS-duration, QRS-area and T-amplitude between women and men. Younger subjects had lower HR (59 vs 72 bpm; p<0.01), higher T-amplitude (530 vs 395 μV; p<0.01), larger T-area (73 vs 48 μVs; p<0.001), shorter QTc (417 vs 430 ms; p<0.01) and a narrower QT-angle (25 vs 59°; p<0.01).

    The response to strenuous exercise was much more pronounced in the younger subjects with an increase in resting HR by 35 bpm compared with 17 bpm for the old subjects (p<0.001). This was accompanied by a more pronounced decrease in T-amplitude (-138 vs -27 μV; p<0.01) and T-area (-20 vs -7 μVs; p<0.01) but a larger prolongation of QTc (54 vs 10 ms; p<0.001).

    Conclusion:

    Young people seem to have a more active ANS, which results in a more pronounced repolarization response to heavy exercise. This might explain why patients with LQT1 more likely suffer from malignant arrhythmias at ages below 40 years.

  • 46.
    Wecke, Liliane
    et al.
    Dept of Cardiology, Karolinska sjukhuset & Karolinska Institutet.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Nilsson, Johnny
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Lundahl, Gunilla
    Bergfeldt, Lennart
    Younger People Show More Changes in Repolarization with Exercise2012In: Younger People Show More Changes in Repolarization with Exercise, 2012Conference paper (Other academic)
    Abstract [en]

    Purpose:

    Cardiac repolarization is a complex phenomenon that depends on heart rate (HR), autonomic nervous system (ANS) activity, age, gender and diseases/pathological conditions etc. Cardiovascular events in LQT1 mutation carriers are also typically related to age, gender, and QT interval, and are triggered by physical exercise. We studied the repolarization response to heavy exercise in healthy subjects.

    Method:

    Vectorcardiography (VCG) was recorded with the Coronet II system (Ortivus AB, Danderyd, Sweden) using the Frank orthogonal lead system (X, Y and Z) at supine rest before and after a maximal cycle ergometer test in 42 healthy subjects. They were of different age and gender, 21 old (64-79 years) and 21 young (20-32 years), 23 were women and 19 men. Maximum T-vector amplitude and direction were assessed as well as T-area, QTc-interval and other VCG parameters.

    Summary:

    At baseline most parameters differed between old and young subjects, but only QRS-duration, QRS-area and T-amplitude between women and men. Younger subjects had lower HR (59 vs 72 bpm; p<0.01), higher T-amplitude (530 vs 395 μV; p<0.01), larger T-area (73 vs 48 μVs; p<0.001), shorter QTc (417 vs 430 ms; p<0.01) and a narrower QT-angle (25 vs 59°; p<0.01).

    The response to strenuous exercise was much more pronounced in the younger subjects with an increase in resting HR by 35 bpm compared with 17 bpm for the old subjects (p<0.001). This was accompanied by a more pronounced decrease in T-amplitude (-138 vs -27 μV; p<0.01) and T-area (-20 vs -7 μVs; p<0.01) but a larger prolongation of QTc (54 vs 10 ms; p<0.001).

    Conclusion:

    Young people seem to have a more active ANS, which results in a more pronounced repolarization response to heavy exercise. This might explain why patients with LQT1 more likely suffer from malignant arrhythmias at ages below 40 years.

  • 47.
    Andersson, Eva
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Nilsson, Johnny
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Can a six-minute shuttle walk test predict maximal oxygen uptake?2011In: Gazzetta Medica Italiana, ISSN 0393-3660, E-ISSN 1827-1812, Vol. 170, no 3, p. 163-70Article in journal (Refereed)
    Abstract [en]

    Aim. This study evaluates the results of and correlations between the six-minute walk-test (6MWT) and a maximal oxygen uptake (VO2max) test among physically active young adults.

    Methods. Sixty-three adults (33 females and 30 males) aged 18-38 years participated. 6MWT and a maximal running treadmill test for measurements of VO2max were performed. 6MWT reliability was also evaluated.

    Results. Mean distance in the 6MWT for the females was 848 (685-976) m and for the males 866 (704-1077) m. The gender differences were considerably less for the 6MWT (2%) than in the VO2max test, both normalized to body weight (21%) and in absolute form (35%). The mean values, for the female and male subjects in the VO2max were 46.7 and 58.9 ml/kg/min and 2.94 and 4.53 l/min, respectively. The data showed a very low, not significant, correlation (r=-0.02-0.32) between walking distance in the 6MWT and VO2max.

    Conclusions: The 6MWT-distance for this physically active young adult group, which previously not has been studied, was considerably higher than in earlier reports for various other groups. In contrast to several prior studies, especially involving people with various diseases, the present data, on healthy active adults, showed that distance in the 6MWT cannot predict maximal oxygen uptake. The present results may be related to the low potential of walking as a locomotor form to tax the cardio-respiratory system sufficiently for this group. Since aerobic capacity is correlated with increased survival, these new data and given comparisons with previous reports are specially valuable when evaluating fitness in various sports and health contexts. 

     

  • 48.
    Andersson, Eva A
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Lundahl, Gunilla
    Ortivus AB, Danderyd.
    Wecke, Liliane
    Institutionen för Kardiologi, KI, KS.
    Lindblom, Ida
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Nilsson, Johnny
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Maximal Aerobic Power versus Performance in Two Aerobic Endurance Tests among Young and Old Adults2011In: Gerontology, ISSN 0304-324X, E-ISSN 1423-0003, no Aug, p. 1-11Article in journal (Refereed)
    Abstract [en]

    Background: Aerobic fitness is of great value for reducing risk of mortality and cardiovascular diseases. Objective: This study evaluated the performance in and correlations between a new test (five-minute pyramid test, 5MPT), the six-minute walk-test (6MWT) and maximal oxygen uptake (VO(2max)) among old and young adults. Methods: Forty-four habitually active adults (females and males), 23 old (64-79 years) and 21 young (20-32 years) participated. In the 5MPT, the participants moved back and forth along a short walkway (5.5 m) over boxes (height: 'old people' 0.42 m, 'young people' 0.62 m) arranged like an elongated step pyramid for 5 min. Power in the pyramid test (5MPT(power)) was calculated as the product of numbers of laps, body weight, gravity and highest box level divided by time. A 6MWT and a maximal cycle ergometer test for direct measurements of VO(2max) were also performed. In all tests heart rate, with on-line electrocardiography, and perceived exertion were recorded. Results: There was a strong correlation between the 5MPT(power) and VO(2max) for the entire group studied (r = 0.98), and each of the four subgroups old and young females and males separately (r = 0.78-0.98). Contrary to several earlier studies, especially involving people with various diseases, the present data showed that 6MWT cannot be used to predict VO(2max) among old females and young adults. The correlation with VO(2max) was weaker for the 6MWT than for the 5MPT(power). The relative performance values for the old compared to the young (ratio old/young × 100) were considerably lower in 5MPT(power) and VO(2max) (47-55%) than in distance and 'work' in the 6MWT (82-86%). Conclusions: The results, with age and gender variations, can be valuable information in health-fitness contexts, since measuring physical aerobic capacity is very significant in connection with risk evaluations of mortality and various diseases. The 5MPT is a rapid, functional, easy and inexpensive tool for predicting assessed maximal aerobic power.

  • 49. Kjellman, Bengt
    et al.
    Martinsen, Egil W
    Aker University Hospital, University of Oslo, Norway.
    Taube, Jill
    Center for Family and Community Medicine, Karolinska Institutet, Stockholm Sweden.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Depression2010In: Physical Activity in the Prevention and Treatment of Disease, Stockholm: Statens folkhälsoinstitut , 2010, p. 325-335Chapter in book (Other academic)
    Abstract [en]

    Physical activity has a positive effect in depression with respect to both preventing depressive episodes, and acute and long-term treatment of episodes that do occur. The physical training is beneficial when conducted parallel to customary treatment with drugs and therapy. Although many studies have methodological problems and there is still a shortage of long term-studies, there is scientific support for using physical training in the acute treatment of mild and moderate depression and as a means to reduce the risk of relapse. A preventive effect has been shown in epidemiological studies and long-term studies followed up to 10 years. Other health effects of physical activity activity are also of importance, as depression often covariates with physical diseases. Physical activity holds great benefit both for the individual and for society.  

  • 50.
    Oddsson, Kristjan
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Danielsson, Evelina
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Nilsson, Johnny
    Swedish School of Sport and Health Sciences, GIH. Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Wahlgren, Lina
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, The Laboratory of Applied Sports Science (LTIV).
    Development of physical tests and ratings scales of perceived health in a project with supervised physical activity for elderly.2010Conference paper (Refereed)
    Abstract [en]

    Background: Valid and reliable field tests for measuring physical fitness and different health parameters is an important matter for evaluating effects of exercise interventions.

    Purpose: The aim was to study different test parameters such as aerobic capacity, strength, perceived health and life style habits, such as physical activity, in a physical activity intervention for elderly people.

    Method: 117 old-age pensioners (99 women and 18 men). Their mean age (yrs) and BMI (kg/m2 ) was 74 and 26 for the women and 73 and 25 for the men, respectively. Different aerobic, strength and balance tests were measured. Guided physical activity (nordic walking, strength training, aqua gymnastics), were given 45-60 min, 2 times/week for 8-12 weeks. Perceived exertion ratings during the exercises were moderate and/or strong.

    Results: Significant changes (p< 0,05) were seen between pre- and post tests regarding all physical tests except the balance test for men. Even the perceived physical and mental health significantly improved. The mean values for questions concerning self reported inactive/active life style, including sedentary time, were changed to a more active life style.

    Conclusion: 8-12 weeks of guided physical activity can improve several physiological parameters which are positively correlated to decreased risk of numerous diseases. More research is needed to develop reliable and valid field tests for physical capacity and different health parameters.

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