The paper aims to, together with youth, create knowledge regarding their relation to health, food choices, and how these can be expressions of their ability to achieve desired health-related goals. A specific focus is how youths experience that their health goals and food choices are affected by social, political and commercial determinants of health and how resulting health literacy capabilities relate to the sustainability challenge of antimicrobial resistance. To this end, a structured observational study was conducted in a region of Zimbabwe to explore youth's health literacy capabilities.