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  • 101.
    Ekblom, Örjan
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Ekblom-Bak, Elin
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Bolam, Kate A
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Schmidt, Caroline
    Söderberg, Caroline
    Bergström, Göran
    Börjesson, Mats
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Concurrent and predictive validity of physical activity measurement items commonly used in clinical settings- data from SCAPIS pilot study.2015In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 15, article id 978Article in journal (Refereed)
    Abstract [en]

    BACKGROUND:

    As the understanding of how different aspects of the physical activity (PA) pattern relate to health and disease, proper assessment is increasingly important. In clinical care, self-reports are the most commonly used assessment technique. However, systematic comparisons between questions regarding concurrent or criterion validity are rare, as are measures of predictive validity. The aim of the study was to examine the concurrent (using accelerometry as reference) and predictive validity (for metabolic syndrome) of five PA questions.

    METHODS:

    A sample of 948 middle-aged Swedish men and women reported their PA patterns via five different questions and wore an accelerometer (Actigraph GT3X) for a minimum of 4 days. Concurrent validity was assessed as correlations and ROC-analyses. Predictive validity was assessed using logistic regression, controlling for potential confounders.

    RESULTS:

    Concurrent validity was low-to-moderate (r <0.35 and ROC AUC <0.7) with large misclassifications regarding time spent sitting/sedentary and in moderate-to vigorous PA. The predictive validity of the questions was good, and one question (PHAS) showed an 80 % decreased odds-ratio of having metabolic syndrome, after taking potential confounders into consideration.

    DISCUSSION:

    In this mixed sample of adults, both concurrent and predictive validity vaired between items and between measures of the physical activity pattern. The PHAS and WALK items are proposed for assessment of adherence to PA recommendations.

    CONCLUSION:

    Assessing PA patterns using self-report measures results in methodological problems when trying to predict individual risk for the metabolic syndrome, as the concurrent validity generally was low. However, several of the investigated questions may be useful for assessing risk at a group level, showing better predictive validity.

  • 102.
    Ekblom, Örjan
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Kraepelien Strid, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Tidén, Anna
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Forskningsgruppen för pedagogik, idrott och fritidskultur.
    Nyberg, Marie
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Sundblad, Gunilla Brun
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Lundvall, Suzanne
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Forskningsgruppen för pedagogik, idrott och fritidskultur.
    Predictors of adolescent fitness levels among Swedish adolescents, a longitudinal study2012In: Journal of Science and Medicine in Sport, 2012, Vol. 15, no Supplement 1, p. S185-Conference paper (Other academic)
    Abstract [en]

    Introduction: It has been consistently demonstrated that low aerobic fitness is causally linked to increased cardio-metabolic risk. Aerobic fitness has also been causally related to cognitive function. From adolescence and onwards, the inter-individual stability ("tracking") in fitness is fairly high. An individual's fitness level in adolescence is therefore a central determinant for future health. However, childhood predictors of adolescent fitness levels are largely unknown. The present study aimed at identifying personal, school-specific and structural determinants in childhood (age 10 yrs) for adolescent aerobic fitness (at age 16 yrs).

    Methods: Body mass index-based overweight status (normal weight vs overweight/obese, according to Cole et al.) and gross motor skills (based on the Tidén-Nyberg test) were measured at baseline in 209 Swedish children (mean [SD] age 9.8 [0.60] yrs) from randomly selected schools on Sweden. Immigration status (self-report) and average household income in quartiles on community level (register obtained) were used as possible structural confounders. Data on educational status of the PE teacher and lesson structure (gender-separated vs mixed classes) was obtained from the PE teacher. At the reexamination (at age 15.8 [0.33] yrs), aerobic fitness was estimated using the Åstrand-Ryhming nomogram. Low aerobic fitness was defined as below the first quartile (29.7 mL x min-1 x kg-1). Risk for low aerobic fitness was assessed using logistic regression

    Results: Risk for low aerobic fitness at follow-up was lower in children who were normal weight (OR: 0.23.95% CI: 0.10 to 0.49) and in children with trained PE-teachers (OR: 0.40, 95% CI: 0.17 to 0.93), but higher among children with poor gross motor skills (OR:1.84, 95% CI 1.08 to 3.13) at baseline. Gender, immigration history, neighborhood economical status and lesson structure were all non-significant predictors of low adolescent fitness.

    Discussion: The results stress the importance for early overweight prevention and treatment and for professional identification and treatment of children with impaired gross motor skills at young ages. In Sweden, a lagre proportion of PE-teachers in lower grades lack formal PE-teacher education, which according to the present study poses a threat to children's future health. Early screening and treatment of children with limited motor proficiencies seems may help children adapting a physically active lifestyle and avoiding low fitness levels in adolescence and young adulthood.

  • 103.
    Ekblom, Örjan
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Kraepelien Strid, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Tidén, Anna
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Forskningsgruppen för pedagogik, idrott och fritidskultur.
    Nyberg, Marie
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Sundblad, Gunilla Brun
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Lundvall, Suzanne
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Forskningsgruppen för pedagogik, idrott och fritidskultur.
    Predictors of perceived competence in physical activities (PCPA) among Swedish adolescents, a longitudinal study2012In: Journal of Science and Medicine in Sport, 2012, Vol. 15, no Supplement 1, p. S113-Conference paper (Other academic)
    Abstract [en]

    Introduction: An individual's perceived competence in physical activities (PCPA) has been proven a powerful predictor for future physical activity. However, the perception of one¥s competence may differ over time, especially during childhood and adolescence but also between types of physical activities or tasks. Further, the predictors for PCPA are largely unknown, but overweight status and gross motor skills have been proposed as candidates. We sought to identify predictors for general PCPA in Swedish adolescents, and PCPA in three highly prevalent forms of physical activities in Swedish physical education (PE), namely swimming, aerobics and soccer.

    Methods: Body mass index-based overweight status (normal weight vs overweight/obese, according to Cole et al.) and gross motor skills (based on the TidÈn-Nyberg test) were measured in 352 Swedish children (160 girls and 192 boys) at baseline (age 10). Immigration status (self-report) and average community household income level (quartiles, register obtained) at 10 yrs were used as possible socio-cultural confounders. Data on educational status of the PE teacher responsible for education at age 10 yrs was obtained by self-report from the teachers. Self reported data on general PCPA and PCPA in soccer, swimming and aerobics at 16 yrs was obtained at follow-up and predictors for PCPA was identified using logistic regression.

    Results: Being overweight or obese (OR: 2.27, 95% CI: 1.18–4.38) and attending PE classes with unqualified teachers (OR: 2.41, 95% CI: 1.36–4.27) at age 10 yrs were both risk factors for low general PCPA a age 16 yrs. Concerning the selected activities, being overweight or obese at age 10 yrs predicted low PCPA in swimming (OR: 2.67, 95% CI:1.31–5.46) but not in the other activities at age 16 yrs. Poor gross motor skills at age 10 yrs predicted low PCPA at 16 yrs only in soccer (OR:1.48, 95% CI: 1.02–2.13). Female gender (OR: 0.21, 95% CI: 0.13–0.38), and higher socioeconomic status (OR: 0.71 per quartile, 95% CI: 0.55–0.92)at age 10 yrs were both found to be associated to lower risk for low PCPA in aerobics.

    Discussion: Overweight status and educational status of the PE teacher both affect the risk of having low general PCPA. The effect of gender, overweight status, gross motor skill and socio-economy seem to differ between specific activities, indicating that PCPA may be task specific in adolescents. These results may serve as background when planning physical activity interventions. Further, they stress the need for professional PE teachers to teach in younger classes.

  • 104.
    Ekblom, Örjan
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Nyberg, Gisela
    Karolinska Institutet.
    Ekblom Bak, Elin
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Ekelund, Ulf
    Cambridge University.
    Marcus, Claude
    Karolinska Institutet.
    Validity and comparability of a wrist-worn accelerometer in children.2012In: Journal of Physical Activity and Health, ISSN 1543-3080, E-ISSN 1543-5474, Vol. 9, no 3, p. 389-393Article in journal (Refereed)
    Abstract [en]

    BACKGROUND:

    Wrist-worn accelerometers may provide an alternative to hip-worn monitors for assessing physical activity as they are easier to wear and may thus facilitate long-term recordings. The current study aimed at a) assessing the validity of the Actiwatch (wrist-worn) for estimating energy expenditure, b) determining cut-off values for light, moderate, and vigorous activities, c) studying the comparability between the Actiwatch and the Actigraph (hip-worn), and d) assessing reliability.

    METHODS:

    For validity, indirect calorimetry was used as criterion measure. ROC-analyses were applied to identify cut-off values. Comparability was tested by simultaneously wearing of the 2 accelerometers during free-living condition. Reliability was tested in a mechanical shaker.

    RESULTS:

    All-over correlation between accelerometer output and energy expenditure were found to be 0.80 (P < .001).Based on ROC-analysis, cut-off values for 1.5, 3, and 6 METs were found to be 80, 262, and 406 counts per 15 s, respectively. Energy expenditure estimates differed between the Actiwatch and the Actigraph (P < .05). The intra- and interinstrument coefficient of variation of the Actiwatch ranged between 0.72% and 8.4%.

    CONCLUSION:

    The wrist-worn Actiwatch appears to be valid and reliable for estimating energy expenditure and physical activity intensity in children aged 8 to 10 years.

  • 105.
    Ekblom, Örjan
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Oddsson, Kristjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Health-related fitness in Swedish adolescents between 1987 and 2001.2004In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 93, no 5, p. 681-6Article in journal (Refereed)
    Abstract [en]

    AIM: To assess trends in neuro-muscular and cardio-respiratory fitness and morphological fitness in Swedish adolescents between 1987 and 2001. METHODS: Comparison of data from two samples, one from 1987 (n = 479) and one from 2001 (n = 1470). Subjects underwent functional tests of muscular strength in the lower limbs, trunk and upper body, sub-maximal ergometrics, and measurement of body mass and height. RESULTS: Cardio-respiratory fitness showed only small changes between 1987 and 2001 among boys, with no changes in girls. Neuro-muscular fitness, as measured by three functional tests, was lower in 2001 compared to 1987. The most pronounced changes in these functional tests were found in the arm-hang test, while changes in lower body and trunk strength tests were less. Our results indicate that the difference in the prevalence of overweight in adolescents between 1987 and 2001 is mainly due to a large change in the most unfit group. The fittest group showed only marginal changes. CONCLUSION: We suggest that the differences in neuro-muscular fitness are at least partly due to differences in the amount and nature of physical activity, and that this might lead to consequences for health later in life.

  • 106.
    Ekblom, Örjan
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Oddsson, Kristjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Physical performance and body mass index in Swedish children and adolescents2005In: Scandinavian Journal of Nutrition/Næringsforskning, ISSN 1102-6480, E-ISSN 1651-2359, Vol. 49, no 4, p. 172-179Article in journal (Refereed)
    Abstract [en]

    Background: Physical fitness and overweight are both important health-related parameters. Reference data from a population are important for comparisons with children with impairments, different diseases, in habilitation or rehabilitation after injuries. Objective: The aim of the survey was to obtain reference data on physical performance in Swedish children and adolescents aged 10, 13 and 16 years. In addition, height and body mass were assessed and body mass index (BMI) was calculated. Design: In total, 2118 children and adolescents in 48 randomly selected schools in Sweden were invited and 1737 subjects participated. Testing procedures were similar to the Eurofit tests, but with some modifications. Results : Results show generally better performance in boys than in girls and increasing performance with age. BMI increased with age with only small differences between genders. Large variations were found within age and gender groups. Conclusions: The present studyprovides reference data on physical performance and body size in Swedish children and adolescents. The results from the present study may be used to compare performance and anthropometric data over time or between countries, to evaluate performance in different patient groups or to set goals for athletes.

  • 107.
    Ekblom, Örjan
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Oddsson, Kristjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Prevalence and regional differences in overweight in 2001 and trends in BMI distribution in Swedish children from 1987 to 2001.2004In: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 32, no 4, p. 257-63Article in journal (Refereed)
    Abstract [en]

    AIMS: This study was undertaken to assess current prevalence and regional differences of overweight in 2001 and changes in body mass index (BMI) distribution between 1987 and 2001 in Swedish adolescents. METHODS: Comparison was made of two independent samples. For assessment of prevalence and regional differences in 2001, a total of 1732 subjects were used. For trend analyses a total of 1,949 children (516 and 1,470 in 1987 and 2001, respectively), aged 10, 13, and 16 years. RESULTS: The prevalence of overweight in 2001 was between 21.7% and 13.3% for boys and girls aged 10 to 16 years and the prevalence of obesity was between 2.9% and 6.2%. Mean BMI as well as prevalence of overweight and obesity was higher in subjects from schools in smaller towns or from the countryside. Median BMI among adolescents changed from 1987 to 2001, most notably in 13- and 16-year-old children. The prevalence of overweight and obesity combined has changed more than 2.5-fold in children aged 10 to 16 years. In this study, the most pronounced elevation in BMI is found in the upper part of the BMI spectrum. This change is especially apparent in girls. CONCLUSION: The change in mean BMI and prevalence of overweight and obesity in children in this study is mainly due to the pronounced change in BMI at the upper end of the spectrum, indicating that the factors leading to overweight or obesity have changed in only a subgroup of the child population.

  • 108.
    Ekblom-Bak, Elin
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Nytt cykeltest för att mäta konditionen2013In: Svensk Idrottsforskning: Organ för Centrum för Idrottsforskning, ISSN 1103-4629, Vol. 22, no 1, p. 33-35Article in journal (Other academic)
    Abstract [sv]

    Sedan 1960-talet har Åstrandstestet varit ett av världens vanligaste sätt att mäta maximal syreupptagningsförmåga. Det nya Ekblom-Baktestet är lika enkelt och tidseffektivt, men  betydligt mer tillförlitligt. Felmarginalen på individnivå är halverad jämfört med Åstrandtestet.

  • 109.
    Ekblom-Bak, Elin
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Björkman, Frida
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Hellenius, Maj-Lis
    Karolinska Institutet.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    A new submaximal cycle ergometer test for prediction of VO(2max).2014In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 24, no 2, p. 319-326Article in journal (Refereed)
    Abstract [en]

    Maximal oxygen uptake (VO(2max) ) is an important, independent predictor of cardiovascular health and mortality. Despite this, it is rarely measured in clinical practice. The aim of this study was to create and evaluate a submaximal cycle ergometry test based on change in heart rate (HR) between a lower standard work rate and an individually chosen higher work rate. In a mixed population (n = 143) with regard to sex (55% women), age (21-65 years), and activity status (inactive to highly active), a model included change in HR per unit change in power, sex, and age for the best estimate of VO(2max) . The association between estimated and observed VO(2max) for the mixed sample was r = 0.91, standard error of estimate = 0.302 L/min, and mean measured VO(2max)  = 3.23 L/min. The corresponding coefficient of variation was 9.3%, a significantly improved precision compared with one of the most commonly used submaximal exercise tests, the Åstrand test, which in the present study was estimated to be 18.1%. Test-retest reliability analysis over 1 week revealed no mean difference in the estimated VO(2max) (-0.02 L/min, 95% confidence interval: -0.07-0.03). The new test is low-risk, easily administered, and valid for a wide capacity range, and is therefore suitable in situations as health evaluations in the general population.

  • 110.
    Ekblom-Bak, Elin
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Hellénius, Mai-Lis
    Minskat stillasittande lika viktigt som ökad fysisk aktivitet: [Less sitting as important as increased physical activity]2010In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 107, no 9, p. 587-8Article in journal (Other academic)
    Abstract [en]

    There is clear evidence for the benefits of regular physical activity for several major health diseases. Meanwhile, sedentary behaviour, resulting in limited everyday life nonexercise activity and muscular inactivity, is increasing in Sweden. Recent observational studies suggest that prolonged bouts of sitting and lack of whole body muscular movement are independently of additional regular physical activity, strongly associated with common public health diseases and total mortality. This indicates that we are dealing with two distinct behaviours and their effects; a) the benefits of regular physical activity and b) the risks of too much sitting and limited nonexercise everyday life activity.The focus in clinical practice and for guidelines should be to promote and prescribe regular physical activity as well as avoidance of sedentary behaviour.

  • 111.
    Ekblom-Bak, Elin
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group. Karolinska institutet.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Vikström, M
    de Faire, U
    Hellénius, Mai-Lis
    Karolinska institutet.
    The importance of non-exercise physical activity for cardiovascular health and longevity.2014In: British Journal of Sports Medicine, ISSN 0306-3674, E-ISSN 1473-0480, Vol. 48, p. 233-238Article in journal (Refereed)
    Abstract [en]

    Background Sedentary time is increasing in all societies and results in limited non-exercise physical activity (NEPA) of daily life. The importance of low NEPA for cardiovascular health and longevity is limited, especially in elderly.                                

    Aim To examine the association between NEPA and cardiovascular health at baseline as well as the risk of a first cardiovascular disease (CVD) event and total mortality after 12.5 years.

    Study design Cohort study.                                

    Material and methods Every third 60-year-old man and woman in Stockholm County was invited to a health screening study; 4232 individuals participated (78% response rate). At baseline, NEPA and exercise habits were assessed from a self-administrated questionnaire and cardiovascular health was established through physical examinations and laboratory tests. The participants were followed for an average of 12.5 years for the assessment of CVD events and mortality.                                

    Results At baseline, high NEPA was, regardless of regular exercise and compared with low NEPA, associated with more preferable waist circumference, high-density lipoprotein cholesterol and triglycerides in both sexes and with lower insulin, glucose and fibrinogen levels in men. Moreover, the occurrence of the metabolic syndrome was significantly lower in those with higher NEPA levels in non-exercising and regularly exercising individuals. Furthermore, reporting a high NEPA level, compared with low, was associated with a lower risk of a first CVD event (HR=0.73; 95% CI 0.57 to 0.94) and lower all-cause mortality (0.70; 0.53 to 0.98).                                

    Conclusions A generally active daily life was, regardless of exercising regularly or not, associated with cardiovascular health and longevity in older adults.                                

  • 112.
    Ekblom-Bak, Elin
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Bergström, Göran
    Börjesson, Mats
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Isotemporal substitution of sedentary time by physical activity of different intensities and bout lengths, and its associations with metabolic risk.2016In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 23, no 9, p. 967-974Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Time spent being sedentary, regardless of time in exercise, has been associated with metabolic risk using regression modelling. By using isotemporal substitution modelling, the effect of replacing sedentary time with an equal amount of time in physical activity (PA) of different intensities can be considered. The present study aims to investigate the effect of replacing sedentary time with time in light, moderate and vigorous PA to the prevalence of the metabolic syndrome (MetS). Also, replacement of sedentary time by PA of different bout lengths was studied.

    METHODS: In total, 836 participants (52% women), aged 50-64 years, from the SCAPIS pilot study were included. Daily time spent sedentary and in PA of different intensities was assessed using hip-worn accelerometers.

    RESULTS: In this cross-sectional study, replacing 10 minutes of sedentary time with the same amount of light PA was associated with significant lower MetS prevalence, odds ratio (OR) 0.96 (95% confidence interval 0.93-0.98). Replacement with moderate PA resulted in even lower OR, 0.89 (0.82-0.97), with the lowest OR for vigorous PA, 0.41 (0.26-0.66). Participants with high energy intake and high daily sedentary time benefitted more from the replacement of sedentary time with light PA. Significant associations were seen for all bout lengths of light, moderate and vigorous PA in a stepwise-like fashion from one minute to up to 120 minute bouts.

    CONCLUSION: Theoretical substitutions of sedentary time with PA of any intensity and of as little as one minute were associated with significantly lower ORs for MetS. This may be an easily communicable message in clinical practice and for public health purposes.

  • 113.
    Ekblom-Bak, Elin
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Fagman, Erika
    Göteborgs universitet.
    Angerås, Oskar
    Göteborgs universitet.
    Schmidt, Caroline
    Göteborgs universitet.
    Rosengren, Annika
    Göteborgs universitet.
    Börjesson, Mats
    Göteborgs universitet.
    Bergström, Göran
    Göteborgs universitet.
    Fitness attenuates the prevalence of increased coronary artery calcium in individuals with metabolic syndrome.2018In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 25, no 3, p. 309-316, article id 2047487317745177Article in journal (Refereed)
    Abstract [en]

    Background The association between cardiorespiratory fitness, physical activity and coronary artery calcium (CAC) is unclear, and whether higher levels of fitness attenuate CAC prevalence in subjects with metabolic syndrome is not fully elucidated. The present study aims to: a) investigate the independent association of fitness on the prevalence of CAC, after adjustment for moderate-to-vigorous physical activity and sedentary time, and b) study the possible attenuation of increased CAC by higher fitness, in participants with metabolic syndrome. Design Cross-sectional. Methods In total 678 participants (52% women), 50-65 years old, from the SCAPIS pilot study were included. Fitness (VO2max) was estimated by submaximal cycle ergometer test and moderate-to-vigorous physical activity and sedentary time were assessed using hip-worn accelerometers. CAC score (CACS) was quantified using the Agatston score. Results The odds of having a significant CACS (≥100) was half in participants with moderate/high fitness compared with their low fitness counterparts. Further consideration of moderate-to-vigorous physical activity, sedentary time and number of components of the metabolic syndrome did only slightly alter the effect size. Those with metabolic syndrome had 47% higher odds for significant CAC compared with those without metabolic syndrome. However, moderate/high fitness seems to partially attenuate this risk, as further joint analysis indicated an increased odds for having significant CAC only in the unfit metabolic syndrome participants. Conclusions Being fit is associated with a reduced risk of having significant CAC in individuals with metabolic syndrome. While still very much underutilized, fitness should be taken into consideration in everyday clinical risk prediction in addition to the traditional risk factors of the metabolic syndrome.

  • 114.
    Ekblom-Bak, Elin
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Engström, Lars-Magnus
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Forskningsgruppen för pedagogik, idrott och fritidskultur.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    LIV 2000: Motionsvanor, fysisk prestationsförmåga och levnadsvanor bland svenska kvinnor och män i åldrarna 20-65 år2011Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    LIV 2000; syfte och frågeställningar

    LIV 90-studien avspeglade för första gången motionsvanor, fysisk status och övergripande hälsostatus i en väl definierad grupp av hela svenska befolkningen. Följaktligen ledde de resultat som LIV 90-studien redovisade till en rad direkta, centrala och övergripande frågor rörande vilka förändringar av det i många avseenden turbulenta 1990-talet som kunde iakttas i den svenska befolkningen vad gäller fysisk aktivitet, levnadsvanor, fysisk kapacitet och hälsotillstånd. Dessutom finns ett intressant perspektiv att jämföra hur den fysiska aktivitetsgraden, prestationsförmågan och hälsorelaterade variabler ser ut i samma ålderskohort med 10 års mellanrum.

    I stort sett sammanfaller undersökta variabler i LIV 2000 av naturliga skäl med den tidigare LIV 90-studiens, men vissa enkätfrågor har med erfarenheter från denna och andra studier, och den forskning som därefter bedrivits, ytterligare preciserats. Det gäller framförallt frågor om den totala fysiska aktiviteten samt frågor som rör inställning till den egna kroppen, den fysiska förmågan liksom frågor om hinder och förutsättningar att ägna sig åt motion. För att säkerställa möjligheterna att studera trender och eventuella förändringar i befolkningen under 1990-talet var designen och genomförandet av LIV 2000 studien i stort sett identisk med LIV 90. Förutom ett samlat tabellverk över de ingående undersökningsvariablerna i LIV 2000-studien (Bilaga B.1)belyser denna rapport mer specifikt följande  områden och frågeställningar:

    I. Omfattning och inriktning av den vuxna befolkningens motionsvanor samt totala fysiska aktivitet. Hur många är motionärer? Hur många är tillräckligt fysiskt aktiva? Motionär och fysiskt aktiv – är det samma  sak?

    II. Fysisk prestationsförmåga; kondition, balans, ben- och bukmuskelstyrka. Hur skiljer det mellan könen och olika åldrar? Hur många har en låg fysisk prestationsförmåga?

    III. Psykisk och fysisk hälsa. Hur är den upplevda hälsan? Och hur är den metabola hälsan? Hur många har en samlad metabol riskbild?

    IV. Förändringar och trender av motionsvanor, total fysisk aktivitet, fysisk prestationsförmåga, livsstil och hälsotillstånd mellan LIV 90 och LIV 2000. Vad hände mellan 1990 och början av 2000-talet? Vilka hälsomässiga riskgrupper finns i befolkningen?

    Innehåll

    1. Bakgrund

    2. Metod och genomförande

    3. Deltagare

    4. Motionsvanor och fysisk aktivitet

    5. Fysisk prestationsförmåga

    6. Hälsa

    7. LIV 90 och LIV 2000 - Vad har hänt över 10 år?

    8. Sammanfattning

    B. 1 Tabellverk

    B. 2 Enkät och testprotokoll

  • 115.
    Ekblom-Bak, Elin
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Hellenius, Maj-Lis
    Karolinska institutet.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Engström, Lars-Magnus
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Forskningsgruppen för pedagogik, idrott och fritidskultur.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Fitness and abdominal obesity are independently associated with cardiovascular risk.2009In: Journal of internal medicine, ISSN 1365-2796, no 21 MayArticle in journal (Refereed)
    Abstract [en]

    Objectives. To examine the relationship between cardiovascular fitness (VO(2)max) and abdominal obesity (waist circumference) and individual cardiovascular disease (CVD) risk factors, as well as a clustered risk factor profile, and to study the impact of gender, age and smoking on these relationships. Design. Cross-sectional. Setting. Astrand Laboratory of Work Physiology, Swedish School of Sport and Health Sciences, Stockholm, Sweden. Subjects. Men (n = 781) and women (n = 890) from two random population-based samples of Swedish women and men aged 20 to 65 years. Main outcomes. Odds ratios. Results. Each unit of higher fitness was associated with a decrease in all individual risk factors ranging from 2% to 4% independent of waist circumference, each unit of higher waist circumference was associated with an increased risk ranging from 2% to 5% independent of fitness. For clustering of three or more of the risk factors, each unit of fitness was associated with a 5% decrease in risk and each unit of waist circumference with a 5% increase in risk. The clustered risk was higher in unfit participants who were older or smoked daily, regardless of waist circumference. Obese participants were at higher risk if they were men or older, regardless of fitness level. However, neither a higher fitness level nor lean status reduced the risk associated with smoking. Conclusions. Higher fitness and lower waist circumference are each independently associated to a similar extent with a lower CVD risk. Simultaneous evaluation of both fitness and abdominal obesity status in clinical practice is important.

  • 116.
    Ekblom-Bak, Elin
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Hellénius, Mai-Lis
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Are we facing a new paradigm of inactivity physiology?2010In: British Journal of Sports Medicine, ISSN 0306-3674, E-ISSN 1473-0480, Vol. 44, no 12, p. 834-5Article in journal (Refereed)
    Abstract [en]

    Evidence for the benefits of regular physical activity for several major health diseases is clear and unanimous. Current public health guidelines are promoting at least 150 minutes per week of moderate to vigorousintensity leisure-time physical activity.

    Recent, observational studies have suggested that prolonged bouts of sitting time and lack of whole-body muscular movement are strongly associated with obesity, abnormal glucose metabolism, diabetes, metabolic syndrome, cardiovascular disease (CVD) risk and cancer, as well as total mortality independent of moderate to vigorous-intensity physical activity.1,–,5 Accordingly, a possible new paradigm of inactivity physiology is suggested, separate from the established exercise physiology, that is, molecular and physiological responses to exercise.6 This new way of thinking emphasises the distinction between the health consequences of sedentary behaviour, that is, limiting everyday life non-exercise activity and that of not exercising. Until now, the expression “sedentary behaviour” has misleadingly been used as a synonym for not exercising. Sedentary time should be defined as the muscular inactivity rather than the absence of exercise.

  • 117.
    Ekblom-Bak, Elin
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Hellénius, Mai-Lis
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Engström, Lars-Magnus
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Forskningsgruppen för pedagogik, idrott och fritidskultur.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Independent associations of physical activity and cardiovascular fitness with cardiovascular risk in adults.2010In: European Journal of Cardiovascular Prevention & Rehabilitation, ISSN 1741-8267, E-ISSN 1741-8275, Vol. 17, no 2, p. 175-80Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Uncertainty still exists whether physical activity (PA) and cardiovascular fitness (CF) contribute separately to cardiovascular disease (CVD) risk. This study examined the associations of PA and CF on individual as well as clustered CVD risk factors. DESIGN: Cross-sectional. METHODS: Seven hundred and eighty-one men and 890 women, aged 20-65 years, from two random population-based samples of Swedish women and men were included. PA was assessed by questionnaire and CF was predicted by a submaximal cycle ergometry test. Waist circumference, blood pressure, and fasting levels of blood lipids were assessed and dichotomized by conventional cut-off points. RESULTS: Participants reporting high PA level benefited from lower triglycerides and atherogenic cholesterol levels, regardless of CF. Higher CF level was, regardless of PA, associated with lower risk for all risk factors. With regard to clustering of risk factors, each higher CF level was associated with a gradually reduced risk by half or more, independent of PA. Furthermore, being unfit but reporting high PA was associated with a 50% lower risk compared with being unfit and inactive. Furthermore, high reported PA was associated with an additional reduced risk among fit participants. In addition, an excess risk of interaction was found for waist circumference, triglycerides, and the clustered CVD risk between neither being sufficiently active nor being fit. CONCLUSION: This study suggests that both PA and CF are independently associated with lower cardiovascular risk, and that both variables should be taken into account when CVD risk is estimated.

  • 118.
    Ekblom-Bak, Elin
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Olsson, Gustav
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Bergström, Göran
    Göteborgs universitet.
    Börjesson, Mats
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    The Daily Movement Pattern and Fulfilment of Physical Activity Recommendations in Swedish Middle-Aged Adults: The SCAPIS Pilot Study.2015In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, no 5, article id e0126336Article in journal (Refereed)
    Abstract [en]

    Different aspects of the daily movement pattern-sitting, light intensity physical activity, and moderate- and vigorous intensity physical activity-have each independently been associated with health and longevity. Previous knowledge of the amount and distribution of these aspects in the general Swedish population, as well as the fulfilment rate of physical activity recommendations, mainly relies on self-reported data. More detailed data assessed with objective methods is needed. The aim of the study was to present descriptive data on the daily movement pattern in a middle-aged Swedish population assessed by hip-worn accelerometers. The cohort consisted of 948 participants (51% women), aged 50 to 64 years, from the Swedish CArdioPulmonary bioImage pilot Study. In the total sample, 60.5% of accelerometer wear time was spent sitting, 35.2% in light physical activity and 3.9% in moderate- and vigorous physical activity. Men and participants with high educational level spent a larger proportion of time sitting, compared to women and participants with low educational level. Men and participants with a high educational level spent more time, and the oldest age-group spent less time, in moderate- and vigorous physical activity. Only 7.1% of the study population met the current national physical activity recommendations, with no gender, age or education level differences. Assessment of all three components of the daily movement pattern is of high clinical relevance and should be included in future research. As the fulfilment of national physical activity recommendations is very low and sitting time is very high in our middle-aged population, the great challenge remains to enhance the implementation of methods to increase the level of physical activity in this population.

  • 119.
    Ekstedt, Mirjam
    et al.
    KTH.
    Nyberg, Gisela
    Karolinska Institutet.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Ingre, Mikael
    Stockholms Universitet.
    Marcus, Claude
    Karolinska Insitutete.
    Sleep, physical activity and BMI in six to ten-year-old children measured by accelerometry: a cross-sectional study.2013In: International Journal of Behavioral Nutrition and Physical Activity, ISSN 1479-5868, E-ISSN 1479-5868, Vol. 22, no 10, p. 82-89Article in journal (Refereed)
    Abstract [en]

    BACKGROUND:

    The aim of this study is to describe the relationship between objective measures of sleep, physical activity and BMI in Swedish pre-adolescents. The day-to-day association between physical activity and sleep quality as well as week-day and weekend pattern of sleep is also described.

    METHOD:

    We conducted a cross sectional study consisted of a cohort of 1.231 children aged six to ten years within the Stockholm county area. Sleep and physical activity were measured by accelerometry during seven consecutive days. Outcome measures are total sleep time, sleep efficiency, sleep start and sleep end; physical activity intensity divided into: sedentary (<1.5 METS), light (1.5 to 3 METS) and moderate-to-vigorous (> 3 METS); and Body Mass Index standard deviations score, BMIsds.

    RESULTS:

    Total sleep time decreased with increasing age, and was shorter in boys than girls on both weekdays and weekends. Late bedtime but consistent wake-up time during weekends made total sleep time shorter on weekends than on weekdays. Day-to-day within-subject analysis revealed that moderate-to-vigorous intense physical activity promoted an increased sleep efficiency the following night (CI < 0.001 to 0.047), while total sleep time was not affected (CI -0.003 to 0.043). Neither sleep duration (CI -0.024 to 0.022) nor sleep efficiency (CI -0.019 to 0.028) affected mean physical activity level the subsequent day. The between-subject analysis indicates that the sleep of children characterized by high moderate-to-vigorous physical activity during the day was frequently interrupted (SE = -.23, P < .01). A negative association between BMIsds and sleep duration was found (-.10, p < .01).

    CONCLUSIONS:

    Short sleep duration was associated with high BMI in six to ten year old children. This study underscores the importance of consistent bedtimes throughout the week for promoting sleep duration in preadolescents. Furthermore, this study suggests that a large proportion of intensive physical activity during the day might promote good sleep quality.

  • 120.
    Enqvist, Jonas K
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Mattsson, C Mikael
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Johansson, Patrik H
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Brink-Elfegoun, Thibault
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Bakkman, Linda
    Swedish School of Sport and Health Sciences, GIH.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Energy turnover during 24 hours and 6 days of adventure racing.2010In: Journal of Sports Sciences, ISSN 0264-0414, E-ISSN 1466-447X, Vol. 28, no 9, p. 947-955Article in journal (Refereed)
    Abstract [en]

    Energy turnover was assessed in two conditions of mixed ultra-endurance exercise. In Study 1, energy expenditure and intake were measured in nine males in a laboratory over 24 h. In Study 2, energy expenditure was assessed in six males during an 800-km Adventure race (mean race time 152.5 h). Individual correlations between heart rate and oxygen uptake ([Vdot]O(2)) were established during pre-tests when kayaking, cycling, and running. During exercise, energy expenditure was estimated from continuous heart rate recordings. Heart rate and [Vdot]O(2) were measured regularly during fixed cycling work rates to correct energy expenditure for drift in oxygen pulse. Mean energy expenditure was 18,050 +/- 2,390 kcal (750 +/- 100 kcal . h(-1)) and 80,000 +/- 18,000 kcal (500 +/- 100 kcal . h(-1)) in Study 1 and Study 2 respectively, which is higher than previously reported. Energy intake in Study 1 was 8,450 +/- 1,160 kcal, resulting in an energy deficit of 9,590 +/- 770 kcal. Body mass decreased in Study 1 (-2.3 +/- 0.8 kg) but was unchanged in Study 2. Fat mass decreased in Study 2 (-2.3 +/- 1.5 kg). In Study 1, muscle glycogen content decreased by only 60%. Adventure racing requires a high energy expenditure, with large inter-individual variation. A large energy deficit is caused by inadequate energy intake, possibly due to suppressed appetite and gastrointestinal problems. The oxygen pulse, comparing start to 12 h of exercise and beyond, increased by 10% and 5% in Study 1 and Study 2 respectively. Hence, estimations of energy expenditure from heart rate recordings should be corrected according to this drift.

  • 121.
    Faager, Gun
    et al.
    Medicin/Thoraxsektionen, sjukgymnastikkliniken Karolinska universitetssjukhuset Solna.
    Söderlund, Karin
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Sköld, Carl Magnus
    Rundgren, Siw
    Tollbäck, Anna
    Jakobsson, Per
    Creatine supplementation and physical training in patients with COPD: a double blind, placebo-controlled study.2006In: International journal of chronic obstructive pulmonary disease, ISSN 1176-9106, Vol. 1, no 4, p. 445-53Article in journal (Refereed)
    Abstract [en]

    STUDY OBJECTIVES: Patients with chronic obstructive pulmonary disease (COPD) have low exercise capacity and low content of high energetic phosphates in their skeletal muscles. The aim of the present study was to investigate whether creatine supplementation together with exercise training may increase physical performance compared with exercise training in patients with COPD. DESIGN: In a randomized, double-blind, placebo-controlled study, 23 patients with COPD (forced expiratory volume in one second [FEV1] < 70% of predicted) were randomized to oral creatine (n = 13) or placebo (n = 10) supplementation during an 8-week rehabilitation programme including exercise training. Physical performance was assessed by Endurance Shuttle Walking Test (ESWT), dyspnea and leg fatigue with Borg CR- 10, quality of life with St George's Respiratory Questionnaire (SGRQ). In addition, lung function test, artery blood gases, grip strength test, muscle strength and fatigue in knee extensors were measured. RESULTS: COPD patients receiving creatine supplementation increased their average walking time by 61% (ESWT) (p < 0.05) after the training period compared with 48% (p = 0.07) in the placebo group. Rated dyspnea directly after the ESWT decreased significantly from 7 to 5 (p < 0.05) in the creatine group. However, the difference between the groups was not statistically significant neither in walking time nor in rated dyspnea. Creatine supplementation did not increase the health related quality of life, lung function, artery blood gases, grip strength and knee extensor strength/fatigue. CONCLUSIONS: Oral creatine supplementation in combination with exercise training showed no significant improvement in physical performance, measured as ESWT, in patients with COPD compared with exercise training alone.

  • 122. Farahmand, B Y
    et al.
    Ahlbom, A
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Hållmarker, U
    Aronson, D
    Brobert, G Persson
    Mortality amongst participants in Vasaloppet: a classical long-distance ski race in Sweden.2003In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 253, no 3, p. 276-83Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: The aim of this study was to assess mortality amongst participants in long-distance ski races during the Vasaloppet week. We considered the 90 km races for men and 90 or 30 km for women. The vast majority of the participants in these races are not competing on the elite level. It is assumed, however, that they have to undergo regular physical training during a long period of time in order to successfully finish the race. DESIGN: The cohort study consisted of 49 219 men and 24 403 women, who participated in any of the races during 1989-1998. All subjects were followed up in the National-Cause-of-Death-Register until 31 December 1999. We computed the standardized mortality ratios (SMRs) adjusting for age and calendar year. RESULTS: Overall, 410 deaths occurred, compared with 850.6 expected, yielding an SMR of 0.48 [95% confidence interval (CI) 0.44-0.53]. Low SMRs were found in all age groups in both men and women and in all groups after categorization by finishing time and number of races. The lowest SMRs were found amongst older participants and in those who participated in several races. A decreased mortality was observed in all major diagnostic groups, namely cancers (SMR = 0.61; 95% CI 0.52-0.71), diseases of the circulatory system (SMR = 0.43; 95% CI 0.35-0.51), and injuries and poisoning (SMR = 0.73; 95% CI 0.60-0.89). For lung cancer the SMR was 0.22, but even after exclusion of lung cancer the all-cancer mortality was low (SMR = 0.72; 95% CI 0.59-0.86). CONCLUSIONS: We conclude that participants in long-distance skiing races, which demand prolonged regular physical training, have low mortality. The extent to which this is due to physical activity, related lifestyle factors, genetics or selection bias is yet to be assessed.

  • 123.
    Fernström, Maria
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Bakkman, Linda
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Tonkonogi, Michail
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Shabalina, Irina
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Rozhdestvenskaya, Z
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Mattsson, C. Mikael
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Enqvist, Jonas K
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Sahlin, Kent
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Reduced efficiency, but increased fat oxidation, in mitochondria from human skeletal muscle after 24-h ultraendurance exercise.2007In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 102, no 5, p. 1844-1849Article in journal (Refereed)
    Abstract [en]

    The hypothesis that ultraendurance exercise influences muscle mitochondrial function has been investigated. Athletes in ultraendurance performance performed running, kayaking, and cycling at 60% of their peak O(2) consumption for 24 h. Muscle biopsies were taken preexercise (Pre-Ex), postexercise (Post-Ex), and after 28 h of recovery (Rec). Respiration was analyzed in isolated mitochondria during state 3 (coupled to ATP synthesis) and state 4 (noncoupled respiration), with fatty acids alone [palmitoyl carnitine (PC)] or together with pyruvate (Pyr). Electron transport chain activity was measured with NADH in permeabilized mitochondria. State 3 respiration with PC increased Post-Ex by 39 and 41% (P < 0.05) when related to mitochondrial protein and to electron transport chain activity, respectively. State 3 respiration with Pyr was not changed (P > 0.05). State 4 respiration with PC increased Post-Ex but was lower than Pre-Ex at Rec (P < 0.05 vs. Pre-Ex). Mitochondrial efficiency [amount of added ADP divided by oxygen consumed during state 3 (P/O ratio)] decreased Post-Ex by 9 and 6% (P < 0.05) with PC and PC + Pyr, respectively. P/O ratio remained reduced at Rec. Muscle uncoupling protein 3, measured with Western blotting, was not changed Post-Ex but tended to decrease at Rec (P = 0.07 vs. Pre-Ex). In conclusion, extreme endurance exercise decreases mitochondrial efficiency. This will increase oxygen demand and may partly explain the observed elevation in whole body oxygen consumption during standardized exercise (+13%). The increased mitochondrial capacity for PC oxidation indicates plasticity in substrate oxidation at the mitochondrial level, which may be of advantage during prolonged exercise.

  • 124.
    Fernström, Maria
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Shabalina, Irina
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Bakkman, Linda
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Tonkonogi, Michail
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Mattsson, C. Mikael
    Swedish School of Sport and Health Sciences, GIH.
    Enqvist, Jonas
    Swedish School of Sport and Health Sciences, GIH.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Sahlin, Kent
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Skeletal muscle mitochondrial function and ROS production in response to extreme endurance exercise in athletes.2006In: 14 European bioenergetic conference, Moscow, Russia, 22-27 July, 2006, 2006Conference paper (Other academic)
    Abstract [en]

    Although it is well known that endurance exercise induces oxidative stress (1) there is no evidence of deteriorated mitochondrial function after 1-2 hours intensive exercise (2). However, the effects of extreme endurance exercise on mitochondrial function and mitochondrial ROS production have not been investigated previously. Nine healthy well-trained men (age 27.1 ± 0.87 (mean ± SE), BMI 24.2 ± 0.64 and VO2 peak 62.5 ± 1.78 ml/kg. min) performed 24 hours exercise, consisting of equal parts running, cycling and paddling. Muscle biopsies were taken from vastus lateralis pre-exercise (PreEx), immediately post-exercise (PostEx) and after 28 hours of recovery (PostEx-28). Mitochondria were isolated and mitochondrial respiration was analyzed with palmitoyl-carnitine (PC) and pyruvate (Pyr). Mitochondrial H2O2 release was measured with the Amplex Red-horseradish peroxide method. The reaction was initiated by addition of succinate with following addition of antimycin A (reversed electron flow). UCP3 protein expression, evaluated with western blot technique, was not changed by exercise. Both state 3 (Pyr and PC) and state 4 (PC) rates of oxygen consumption (estimated per maximal ETC-activity) were increased PostEx (+29%, +11% and +18%). State 3 remained elevated PostEx-28, whereas state 4 (Pyr) decreased below that at PreEx (-18%). Mitochondrial efficiency (P/O) decreased PostEx (Pyr -8.9%, PC -6.1%) and remained reduced PostEx-28. The relative substrate oxidation (state 3 PC/Pyr) increased after exercise PreEx: (0.71 ± 0.06 vs. PostEx (0.90 ±0.04) and (0.77 ±0.06) PostEx-28. Mitochondrial H2O2 release (succinate) increased dramatically after exercise (+189 ± 64%). Treatment with Antimycin A resulted in a twofold-increased rate of mitochondrial H2O2 release PreEx but a decreased rate in PostEx samples. The exercise-induced changes in mitochondrial ROS production was totally abolished PostEx-28. In conclusion extreme endurance exercise decreases mitochondrial efficiency and increases mitochondrial ROS production. Both of these changes would increase the oxygen demand during exercise. Relative fatty acid oxidation as measured in isolated mitochondria increased after exercise indicating that the capacity to oxidize fat is improved during prolonged exercise.

    1. Mastaloudis, A., S.W. Leonard, and M.G. Traber, Oxidative stress in athletes during extreme endurance exercise. Free Radic Biol Med, 2001. 31(7): p. 911-22.

    2. Tonkonogi, M., et al., Mitochondrial function and antioxidative defence in human muscle: effects of endurance training and oxidative stress. J Physiol, 2000. 528 Pt 2: p. 379-88.

  • 125.
    Flockhart, Mikael
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Mattsson, C. Mikael
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Validation of modified D-max method for calculating individual anaerobic threshold in well trained male cyclists2015Conference paper (Refereed)
    Abstract [en]

    Introduction

    To predict endurance performance and evaluate adaption to training in endurance athletes a laboratory test for retrieving the anaerobic lactate threshold is often used. The maximal rate of oxidative metabolism that can be sustained during prolonged exercise indicates preserved homeostasis and thereby sets the upper limit for long term endurance. Exercise intensities above the anaerobic threshold require an additional input from anaerobic energy sources resulting in blood lactate accumulation and reduced time to fatigue. The threshold is therefore a reliable and powerful predictor of performance in aerobic exercise lasting approximately 40-60 min. The work rate that elicits a blood lactate of 4 mmol/l (e.g. LT4) is widely used to determine the threshold, but by using a fixed lactate concentration, flexibility to account for inter- and intra-individual differences in aerobic and anaerobic metabolism is lost. Our hypothesis was that our modified D-max method (D-maxmod) would provide a more accurate performance related value by calculating the individual anaerobic threshold (IAT).

    Methods

    20 males cyclists age 36 ± 5 years, weight 79.7 ± 5.8 kg, VO2max 4.4 ± 0.4 l/min performed an incremental test on a cycle ergometer for calculation of LT (D-maxmod, and LT4) at two occasions separated by 8 weeks. The test consisted of 5 minutes long stages separated by 1 min of rest were lactate was sampled. The increase in work rate was 30 W/stage starting at 100 W and ended above LT4. Short after, an incremental test to fatigue (start at LT4 power, increase 20 W/min) was performed for assessment of VO2max, calculation of maximal aerobic power (MAP) and maximal power achieved in the test (Wmax). On a separate day a 40 minutes time-trial (TT40) was performed for assessment of aerobic endurance performance. IAT D-maxmod was defined as the derivate to the exponential curve created from exponentially lactate increase, including maximal lactate concentration plotted at MAP. The increase in lactate relative to power was defined as the increase in blood lactate from the point where the exponential curve crossed the lactate baseline (See also Cheng et al. 1992 and Zhou & Weston 1997).

    Results

    IAT D-maxmod was calculated to 5.0 ± 0.8 mmol/l. Both D-maxmod and LT4 were highly significantly correlated with both TT40 and Wmax. Coefficients of determination were higher for D-maxmod compared to LT4 for both TT40 (r2 = 0.78 vs 0.69) and Wmax (r2 = 0.89 vs 0.64).

    Conclusion

    The calculated D-maxmod correlated better with performance than LT4 for parameters highly linked to performance in road- and mountain bike competitions.

    References

    Cheng B, Kuipers H, Snyder AC, et al. (1992). Int. J Sports Med. 13:518-22

    Zhou S, Weston SB (1997). Physiol. Meas. 18: 145

  • 126.
    Flockhart, Mikael
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group. Militärmedicinska forskningsgruppen, Åstrand laboratoriet.
    Mattsson, C. Mikael
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences. Militärmedicinska forskningsgruppen, Åstrand laboratoriet.
    Ekblom Bak, Elin
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology. Militärmedicinska forskningsgruppen, Åstrand laboratoriet.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group. Militärmedicinska forskningsgruppen, Åstrand laboratoriet.
    Slutövning GMU: ”Aldrig ge upp”, Amf1, Berga örlogsbas.: Rapport 4.2014Report (Other academic)
    Abstract [sv]

    Energistatus och förändring i fysiskt stridsvärde studerades i samband med en nästan 8 dygn långa grundmilitär slutövning (GMU) vid AMF-1 Berga Örlogsskolor i månadsskiftet oktober november 2013.

    Totalt deltog 105 soldater i övningen, fördelat på 3 plutoner om vardera 35 soldater. En subgrupp på 24 soldater (8 kvinnor) bestående av 8 soldater från vardera pluton studerades mer ingående.

    Medelhjärtfrekvensen för de 6 soldater (2 kvinnor) som hade i stort sett kompletta mätningar från den 187 timmar långa övningen, inklusive viloperioder, var 88 ± 7 slag/minut. Utifrån hjärtfrekvensdata beräknades den totala energiomsättningen till i genomsnitt 44 000 ± 6 600 kcal, vilket motsvarar 5 600 ± 840 kcal per dygn och 235 ± 35 kcal/tim. Total energiförbrukning var i genomsnitt 39 000 kcal för kvinnorna och 46 500 kcal för männen. I övrigt noterades inte några betydande skillnader mellan kvinnor och män. Däremot var det stora individuella variationer i energiutgift, vilka till ca hälften berodde på skillnader i kroppsvikt. Med hänsyn till kroppsvikt och buren vikt var energiförbrukningen ca 3,1 ± 0,23 kcal per timme per kg totalvikt. Den individuella variationen beror på skillnad i buren vikt, på olika uppgifter och på individuella fysiologiska skillnader.

    Utifrån beräknat energiintag blev det totala energiunderskottet under övningen 12 000-15 000 kcal, vilket är ca 1 500-2 000 kcal per dygn. Viktminskningen under övningen var 2,9 kg för kvinnor och 3,7 kg för män. Denna viktminskning på >4 % leder troligen till försämrad uthållighetsförmåga.

    Den maximala muskelstyrkan i armar och ben var i stort sett oförändrade efter övningen, liksom den beräknade maximala syreupptagningsförmågan. Däremot upplevdes ett lågintensivt cykelarbete som betydligt tyngre efter övningen. Muskeluthållighet mättes inte i denna studie.

    Ett skjutprov om 5 skott i liggande på 100 m mot en tredjedelsfigur visade 64 deltagande soldater på en försämrad träffprocent från 90,5% före till 79,4 % efter övningen. Alla soldater hade minst en träff före medan 6 soldater hade alla bom efter övningen.

    Slutsatsen från studien är att GMU-övningen resulterade i ett stort energiunderskott. Stridsvärdet, bedömt från skjutprovet var klart försämrat. Maximala fysiologiska parametrar var i stort sett oförändrade, medan skattad ansträngning och därmed uthållighetsförmåga, försämrades.

  • 127.
    Flockhart, Mikael
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Mattsson, Mikael
    Swedish School of Sport and Health Sciences, GIH.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Fysiologisk analys av utbildningsmomentet "Markstrid grundkurs (GK) 1, Fjällmarsch"2014Report (Other academic)
    Abstract [sv]

    Denna observationsstudie av militär grundutbildning för kadetter visar mycket tydligt att förflyttning i fjällmiljö leder till stort energiunderskott, till viss del beroende på ökade energiutgifter i och med bärande av utrustning, men framför beroende på otillräckligt energiintag.

    Den genomsnittliga energiförbrukningen över övningens 100 timmarna och ca 78 km förflyttning var ca 260 kcal/h, medan energiintaget endast 135 kcal/h. Även om en typ av rations (mjukkonserv) gav i genomsnitt högre energiintag än två rations av frystorkat blev det genomsnittliga energiunderskottet för samtliga rations nästan 50 %.

    Mätningarna visade stora variationer mellan olika deltagare vilket dock endast delvis kan förklaras med tekniken av att bära tungt.

    Skjutprov (precision) visade att stridsvärdet påverkats negativt, genom en klart försämrad träffbild efter övningen. De fysiologiska testerna visar ökad hjärtfrekvens och upplevd ansträngning på submaximala belastningar, medan de maximala nivåerna av de fysiologiska kapaciteterna kondition, muskelstyrka i hand och ben i stort sett var oförändrade.

    Kommande undersökningar på motsvarande övningar bör inriktas på interventionsstudier på fördelning av utrustningsvikter, samt hur kostintaget bör förbättras för att nå ökat energiintag.

    På längre sikt bör träningsmodeller för att förbättra förmågan att bära tung utrustning utvärderas.

  • 128.
    Flygare Wallén, Eva
    et al.
    Karolinska Institutet.
    Müllersdorf, Maria
    Mälardalens universitet.
    Christensson, K
    Mälardalens universitet.
    Malm, Gunilla
    Mälardalens universitet.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Marcus, Claude
    Karolinska Insitutet.
    High prevalence of cardio-metabolic risk factors among adolescents with intellectual disability.2009In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 98, no 5, p. 853-859Article in journal (Refereed)
    Abstract [en]

    Abstract

    Adults with intellectual disabilities (IDs) have poor lifestyle-related health compared with the general population. Our aim was to study whether such differences are present already in adolescents.

    AIM:

    To compare the prevalence and severity of cardio-metabolic risk factors and cardio-vascular fitness in adolescents with and without IDs.

    METHODS:

    Intellectual disability (ID) students (n = 66) and non-intellectual disability (non-ID) students from practical (non-ID-p) (n = 34) and theoretical (non-ID-t) (n = 56) programmes were recruited from three upper secondary schools. Anthropometric data, blood pressure, body composition, fasting-insulin, fasting-glucose, fasting-lipids and cardio-vascular fitness were measured.

    RESULTS:

    Participants with and without ID differed significantly in the prevalence of cardio-metabolic risk factors with participants with ID having a higher percentage of total fat mass, wider waist circumferences (WCs), lower levels of fat-free mass (FFM), lower bone mineral density (BMD) and higher insulin and homeostasis model assessment of insulin resistance (HOMA) levels and poorer cardio-vascular fitness. The healthiest levels were found in the non-ID-t group compared to the group with ID and the group with non-ID-p in between.

    CONCLUSION:

    The prevalence of cardio-metabolic risk factors and poor cardio-vascular fitness was found to be high in this young population with intellectual disabilities. Measures should be taken to improve the health messages directed towards children and adolescents with intellectual disabilities.

  • 129. Flygare Wallén, Eva
    et al.
    Müllersdorf, Maria
    Christensson, Kyllike
    Malm, Gunilla
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Marcus, Claude
    High prevalence of cardio-metabolic risk factors among adolescents with intellectual disability.2009In: Acta paediatrica (Oslo, Norway : 1992), ISSN 1651-2227Article in journal (Refereed)
    Abstract [en]

    Abstract Adults with intellectual disabilities (IDs) have poor lifestyle-related health compared with the general population. Our aim was to study whether such differences are present already in adolescents. Aim: To compare the prevalence and severity of cardio-metabolic risk factors and cardio-vascular fitness in adolescents with and without IDs. Methods: Intellectual disability (ID) students (n = 66) and non-intellectual disability (non-ID) students from practical (non-ID-p) (n = 34) and theoretical (non-ID-t) (n = 56) programmes were recruited from three upper secondary schools. Anthropometric data, blood pressure, body composition, fasting-insulin, fasting-glucose, fasting-lipids and cardio-vascular fitness were measured. Results: Participants with and without ID differed significantly in the prevalence of cardio-metabolic risk factors with participants with ID having a higher percentage of total fat mass, wider waist circumferences (WCs), lower levels of fat-free mass (FFM), lower bone mineral density (BMD) and higher insulin and homeostasis model assessment of insulin resistance (HOMA) levels and poorer cardio-vascular fitness. The healthiest levels were found in the non-ID-t group compared to the group with ID and the group with non-ID-p in between. Conclusion: The prevalence of cardio-metabolic risk factors and poor cardio-vascular fitness was found to be high in this young population with intellectual disabilities. Measures should be taken to improve the health messages directed towards children and adolescents with intellectual disabilities.

  • 130. Forsell, Yvonne
    et al.
    Hallgren, Mats
    Mattson, Maria
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Lavebratt, Catharina
    FitForLife: study protocol for a randomized controlled trial.2015In: Trials, ISSN 1745-6215, E-ISSN 1745-6215, Vol. 16, no 1, article id 553Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Psychosis is a serious mental illness that typically emerges during early adulthood. The disorder is characterized by inactivity, cognitive deficits and the need for ongoing support. Regular exercise has mood enhancing and anxiolytic effects that could benefit this patient group. To date, few studies have examined the effects of prescribed exercise on autonomy, health and cognitive functioning in psychosis.

    METHODS/DESIGN: This is a single-center, randomized controlled trial (RCT) with a 3-month follow-up. Usual care plus a 12-week supervised exercise program will be compared to usual outpatient care alone. The primary outcome will be patient autonomy measured by the Camberwell Assessment of Need (CAN) schedule - clinician rated. Secondary outcomes include cardiovascular risk factors, cognitive functioning, substance abuse, body awareness, depression and mood state. Changes in inflammatory markers and microbiotica will be explored. The feasibility of using patients as exercise trainers will also be assessed.

    DISCUSSION: The treatment potential for exercise in psychosis is large because most individuals with the disorder are young and inactive. The study is one of the first to comprehensively assess the effects of regular exercise in young adults with psychosis. Sessions will be closely supervised and adjusted to meet patient needs. Both the feasibility and treatment effects of exercise interventions in psychosis will be discussed.

    TRIAL REGISTRATION: German Clinical Trials Register DRKS00008991 7 August 2015.

  • 131.
    Frank, Per
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Andersson, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Pontén, Marjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Ekblom, Maria
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Laboratory for Biomechanics and Motor Control.
    Sahlin, Kent
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.
    Strength training improves muscle aerobic capacity and glucose tolerance in elderly2016In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 26, no 7, p. 764-773Article in journal (Refereed)
    Abstract [en]

    The primary aim of this study was to investigate the effect of short-term resistance training (RET) on mitochondrial protein content and glucose tolerance in elderly. Elderly women and men (age 71 ± 1, mean ± SEM) were assigned to a group performing 8 weeks of resistance training (RET, n = 12) or no training (CON, n = 9). The RET group increased in (i) knee extensor strength (concentric +11 ± 3%, eccentric +8 ± 3% and static +12 ± 3%), (ii) initial (0-30 ms) rate of force development (+52 ± 26%) and (iii) contents of proteins related to signaling of muscle protein synthesis (Akt +69 ± 20 and mammalian target of rapamycin +69 ± 32%). Muscle fiber type composition changed to a more oxidative profile in RET with increased amount of type IIa fibers (+26.9 ± 6.8%) and a trend for decreased amount of type IIx fibers (-16.4 ± 18.2%, P = 0.068). Mitochondrial proteins (OXPHOS complex II, IV, and citrate synthase) increased in RET by +30 ± 11%, +99 ± 31% and +29 ± 8%, respectively. RET resulted in improved oral glucose tolerance measured as reduced area under curve for glucose (-21 ± 26%) and reduced plasma glucose 2 h post-glucose intake (-14 ± 5%). In CON parameters were unchanged or impaired. In conclusion, short-term resistance training in elderly not only improves muscular strength, but results in robust increases in several parameters related to muscle aerobic capacity.

  • 132. Fridén, Jan
    et al.
    Seger, Jan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Implementation of periodic acid-thiosemicarbazide-silver proteinate staining for ultrastructural assessment of muscle glycogen utilization during exercise1985In: Cell and Tissue Research, ISSN 0302-766X, E-ISSN 1432-0878, no 242, p. 229-232Article in journal (Refereed)
    Abstract [en]

    Distribution of glycogen particles in semithin and ultrathin sections of biopsy samples from human muscles subjected to either short- or long-term running were investigated using PAS and Periodic Acid-ThioSemiCarbazide-Silver Proteinate (PA-TSC-SP) staining methods. Glycogen particles were predominantly found immediately under the sarcolemma or aligned along the myofibrillar I-band. After long-term exhaustive exercise type-1 fibers with a few or no glycogen particles in the core of the fibers were frequently observed. The subsarcolemmal glycogen stores of these "depleted" type-1 fibers were about three times as large as after exhaustive short-time exercise. Another indication of utilization of subsarcolemmal glycogen stores during anaerobic exercise was that many particles displayed a pale, rudimentary shape. This observation suggests fragmental metabolization of glycogen. Thus, depending on type of exercise and type of fiber differential and sequential glycogen utilization patterns can be observed

  • 133. Fridén, Jan
    et al.
    Seger, Jan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Sublethal muscle fibre injuries after high-tension anaerobic exercise1988In: European Journal of Applied Physiology and Occupational Physiology, ISSN 0301-5548, E-ISSN 1432-1025, no 57, p. 360-368Article in journal (Refereed)
    Abstract [en]

    The vastus lateralis muscles of eleven male elite sprinters (17-28 years) were investigated in order to examine the impact of high tension anaerobic muscular work on muscle fibre fine structure. In an attempt to reproduce the training regimen six subjects ran 20 repetitions of 25 s on a treadmill with 2 min 35 s in between, at a speed corresponding to 86% of their personal best 200 m time. PAS-stained sections of biopsies taken approximately 2 h after training generally indicated glycogen depletion in type 1 and type 2B fibres. At the light microscopic level, no signs of inflammation or fibre rupture were observed. However, at the ultrastructural level, frequent abnormalities of the contractile material and the cytoplasmic organelles were detected. Z-band streaming, autophagic vacuoles and abnormal mitochondria were the most conspicuous observations. Control specimens from sprinters who did not perform the acute exercise routine also displayed structural deviations, although to a lesser degree. It is hypothesized that during sprint training the leg musculature is put under great mechanical and metabolic stress which causes the degenerative response reported here.

  • 134. Fridén, Jan
    et al.
    Seger, Jan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Topographical localization of muscle glycogen: an ultrahistochemical study in the human vastus lateralis1989In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 135, p. 381-391Article in journal (Refereed)
    Abstract [en]

    The fine structural pattern of glycogen storage in resting and sprint-exercised human vastus lateralis muscle fibres of different types was analysed using ultrahistochemical methods. Three male subjects (31-36 years) performed 60 consecutive, supramaximal bouts of bicycle exercise, each starting every 1 min and having a duration of 8 s (including approximately 3 s of acceleration). The load was estimated to correspond to 200% of VO2-max. Five other subjects (22-27 years) constituted controls. Ultrathin sections stained with periodic acid-thiosemicarbazide-silver proteinate (PA-TSC-SP) clearly revealed a compartmental distribution of glycogen. Glycogen is stored at five topographically, and probably also functionally, different locations. They are the subsarcolemmal, intermyofibrillar, para-Z-disc, N2-line, and H-zone spaces. During the exercise, glycogen from the N2-line and para-Z-disc locations is preferentially utilized. Serial sections stained with uranyl acetate and lead citrate demonstrated that glycogen stores of the type 2 fibres were more depleted than those of type 1 fibres. The implications of the differential intracellular glycogen storage are discussed

  • 135. Fridén, Jan
    et al.
    Seger, Jan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Sjöström, Michael
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Adaptive Response in Human Skeletal Muscle Subjected to Prolonged Eccentric Training1983In: International Journal of Sports Medicine, ISSN 0172-4622, E-ISSN 1439-3964, no 4, p. 177-183Article in journal (Refereed)
    Abstract [en]

    The peripheral adaptation process associated with repeating eccentric training over a longer period of time was studied in m. vastus lateralis of eleven healthy males aged 24 +/- 4 years. The maximal dynamic concentric muscle strength was only slightly improved after 8 weeks of training. However, eccentric work capacity was dramatically increased (375%). A maximal eccentric stint immediately after fulfilled 8 weeks of training caused a selective glycogen depletion from the type 28 fibers. An increased number of type 2C fibers was observed. The ultrastructure analysis showed an essentially well-preserved fine structure. Volume density of mitochondria was somewhat higher in all fiber types after training. Z-band widths were not affected by eccentric training. It is concluded that skeletal musculature adapts itself in a functional manner to the extreme tension demands put on them. Improved coordination and reorganization of the contractile apparatus of muscle fibers are the determining mechanisms of this adaptation.

  • 136. Gerber, Markus
    et al.
    Jonsdottir, IH
    Börjesson, Mats
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Lindwall, Magnus
    Lindegård, A gneta
    Changes in Mental Health in Compliers and Non-Compliers with Physical Activity Recommendations in Patients with Stress-Related Exhaustion2015In: Proceedings of the 2015 AIESEP International Conference. Revista Española de Educación Física y Deportes, 410 (Supl.), 3er trimestre., 2015, 2015, Vol. 410 (Supl.), p. 300-301Conference paper (Refereed)
  • 137.
    Godhe, Manne
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group. Militärmedicinska forskningsgruppen, Åstrandlaboratoriet.
    Helge, Torbjörn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group. Militärmedicinska forskningsgruppen, Åstrandlaboratoriet.
    Mattsson, C. Mikael
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences. Militärmedicinska forskningsgruppen, Åstrandlaboratoriet.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group. Militärmedicinska forskningsgruppen, Åstrandlaboratoriet.
    Att bära tungt - en fysiologisk analys: Kvinnor: Rapport 8.2016Report (Other academic)
    Abstract [sv]

    Sjutton kvinnliga vältränade försökspersoner, åtta stycken med vana att bära tungt och nio stycken utan sådan vana, genomförde gång på löpband och mjukt underlag i hastigheterna 3 och 5 km/tim med bärvikter i ryggsäck på 20, 35 och 50 kg.Mjukt underlag i form av blå gymnastikmattor, indikerande gång i lätt terräng, ökade energiomsättningen under både hastigheterna mellan 10 och 15 %, jämfört med hårt underlag (löpband) med en grads lutning. Energiomsättningen ökade i genomsnitt lika mycket med ökad hastighet som med ökad bärvikt. Den individuella variationen vid en given bärvikt och hastighet är mycket stor. Beroende på bärvikt och hastighet kan energiomsättningen variera med 100 %. Dessa stora variationer i energiomsättning bör uppmärksammas vid beräkning av energitilldelning via kosten vid längre militära operationer.Energiomsättningen vid tyngsta belastningen – 50 kilo bärvikt och hastigheten 5 km/tim – belastade försökspersonerna på i genomsnitt 57 % av maximal syreupptagningsförmåga. I individuella fall var belastningen 72 % av maximal syreupptagningsförmåga. Dessa höga belastningar är oacceptabelt höga för transporter under längre tid och kan vara en orsak till belastningsskador.Förmågan att bära tungt sammanfaller med ökad kroppsvikt och benmuskelstyrka. Bärförmåga för mindre vikter, högst 35 kg, sammanfaller inte med någon av ovanstående faktorer. Således, för tyngre bärvikter vid förflyttningar bör selektion av soldater ske enligt de uppmätta parametrarna, medan vad gäller lättare vikter föreligger inte samma selektionskriterier.En slutsats från resultaten av denna undersökning är den ursprungliga uttagningen till tunga arbetsuppgifter inom försvaret bör genomföras med tunga arbetsbelastningar, motsvarande de i denna undersökning. I kommande rapport sammanfattas studierna på män och kvinnors bärförmåga, likheter och olikheter mellan könen, möjliga selektionskriterier samt rekommendationer med utgångspunkt från genomförda undersökningar och resultat från olika andra undersökningar.

  • 138.
    Godhe, Manne
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Helge, Torbjörn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Mattsson, C. Mikael
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Physiological factors of importance for load carriage2017In: ICSPP Abstracts: Journal of Science and Medicine in Sport, November 2017 20 Supplement 2:S105, 2017, Vol. 20, no Supplement 2, p. S105-, article id 176Conference paper (Other academic)
  • 139.
    Godhe, Manne
    et al.
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Helge, Torbjörn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
    Mattsson, C Mikael
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Physiological factors of importance for load carriageManuscript (preprint) (Other academic)
    Abstract [en]

    The energy expenditure during carrying no load, 20, 35 and 50 kg at two walking speeds, 3 and 5 km/h, was studied in 36 healthy participants, 19 men (30 ± 6 yrs, 82.5 ± 7.0 kg) and 17 women (29 ± 6 yrs, 66.1 ± 8.9 kg). Anthropometric data, leg muscle strength as well as trunk muscle endurance and muscle fibre distribution of the thigh were also obtained. To load the participant a standard backpack filled with extra weight according to the carrying weight tested was used. Extra Load Index (ELI), the oxygen uptake (VO2) during total load over no-load-exercise, was used as a proxy for load carrying ability. In addition to analyzing factors of importance for the ELI values, we also conducted mediator analyzes using sex and long term carrying experience as causal variables for ELI as the outcome value. For the lowest load (20 kg), ELI20, was correlated with body mass but no other factors. Walking at 5 km/h body mass, body height, leg muscle strength and absolute VO2max were correlated to ELI35 and ELI50, but relative VO2max, trunk muscle endurance and leg muscle fibre distribution were not. Sex as causal factor was evaluated in a mediator analyses with ELI50 as outcome. ELI50 at 5 km/h differed between the sexes. The limit for acceptable body load, 40% of VO2max (according to Astrand, 1967), was nearly reached for women carrying 35 kg (39%) and surpassed at 50 kg at 3 km/h, and for men carrying 50 kg at 5 km/h. This difference was only mediated by difference in body mass. Neither muscle fibre distribution, leg muscle strength, trunk muscle endurance and body height nor did absolute or relative VO2max explain the difference. Participants with long term experience of heavy load carrying had significant lower ELI20 and ELI50 values than those with minor or non-experience, but none of the above studied factors could explain this difference. The study showed that body mass and experience of carrying heavy loads are important factors for the ability to carry heavy loads.

  • 140.
    Gray, Stuart R
    et al.
    Strathclyde inst of pharmacy and biomedical sciences, university of strathclyde, Glasgow UK.
    Söderlund, Karin
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Ferguson, Richard A
    ATP and phosphocreatine utilization in single human muscle fibres during the development of maximal power output at elevated muscle temperatures.2008In: Journal of Sports Sciences, ISSN 0264-0414, E-ISSN 1466-447X, Vol. 26, no 7, p. 701-7Article in journal (Refereed)
    Abstract [en]

    In this study, we examined the effect of muscle temperature (Tm) on adenosine triphosphate (ATP) and phosphocreatine utilization in single muscle fibres during the development of maximal power output in humans. Six male participants performed a 6-s maximal sprint on a friction-braked cycle ergometer under both normal (Tm = 34.3 degrees C, s = 0.6) and elevated (T(m) = 37.3 degrees C, s = 0.2) muscle temperature conditions. During the elevated condition, muscle temperature of the legs was raised, passively, by hot water immersion followed by wrapping in electrically heated blankets. Muscle biopsies were taken from the vastus lateralis before and immediately after exercise. Freeze-dried single fibres were dissected, characterized according to myosin heavy chain composition, and analysed for ATP and phosphocreatine content. Single fibres were classified as: type I, IIA, IIAX25 (1 - 25% IIX isoform), IIAX50 (26 - 50% IIX), IIAX75 (51 - 75% IIX), or IIAX100 (76 - 100% IIX). Maximal power output and pedal rate were both greater (P < 0.05) during the elevated condition by 258 W (s = 110) and 22 rev . min(-1) (s = 6), respectively. In both conditions, phosphocreatine content decreased significantly in all fibre types, with a greater decrease during the elevated condition in type IIA fibres (P < 0.01). Adenosine triphosphate content was also reduced to a greater (P < 0.01) extent in type IIA fibres during the elevated condition. The results of the present study indicate that after passive elevation of muscle temperature, there was a greater decrease in ATP and phosphocreatine content in type IIA fibres than in the normal trial, which contributed to the higher maximal power output.

  • 141.
    Gray, Stuart R
    et al.
    Institute of medical sciences, University of Aberdeen, Skottland.
    Söderlund, Karin
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Watson, Moira
    Ferguson, Richard A
    Skeletal muscle ATP turnover and single fibre ATP and PCr content during intense exercise at different muscle temperatures in humans.2011In: Pflügers Archiv: European Journal of Physiology, ISSN 0031-6768, E-ISSN 1432-2013, Vol. 462, no 6, p. 885-893Article in journal (Refereed)
    Abstract [en]

    The effect of temperature on skeletal muscle ATP turnover, pulmonary oxygen uptake and single fibre ATP and PCr content was studied during intense cycling exercise. Six healthy male subjects performed 6-min intense (Δ50%LT-VO(2peak)) cycling, at 60 rpm, under conditions of normal (N) and elevated muscle temperature (ET). Muscle biopsies obtained from the vastus lateralis at rest, 2 and 6 min were analysed for homogenate ATP, PCr, lactate and glycogen, allowing estimation of anaerobic ATP turnover. Freeze-dried single fibres from biopsies were characterised according to their myosin heavy chain composition (type I, IIA or IIAX) and analysed for ATP and PCr content. Pulmonary gas exchange was measured throughout. There was no difference in pulmonary oxygen uptake between the trials. The elevation of muscle temperature resulted in a lower (P < 0.05) PCr content, higher (P < 0.05) lactate content and greater (P < 0.05) anaerobic ATP turnover after 2 min of exercise. There was no effect of temperature on these measures at 6 min. In single fibres it was observed that in ET, there was a lower (P < 0.05) PCr content in type I fibres after 2 min with no differences between conditions after 6 min. The present study demonstrates that elevation of muscle temperature results in a greater anaerobic ATP turnover and type I fibre PCr degradation during the initial 2 min of intense exercise.

  • 142. Grimby, Agneta
    et al.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Sätt änkorna i rörelse - för hälsans skull!2002In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 99, no 1-2, p. 78-80Article in journal (Other academic)
    Abstract [sv]

    Sorg är ingen sjukdom, men kan förvisso ge sådan. Ensamhet, isolering, inaktivitet, dåliga matvanor, ökad konsumtion av alkohol och tobak minskar avsevärt ambitionen att röra på sig – bildligt och bokstavligt – och är vanligt bland nyblivna änkepersoner. Kommunal hälso- och psykosocial intervention i form av tidigt stöd  och uppmuntran i sorgen – som skulle kunna bryta negativa mönster – är idag nästan obefintlig. Denna grupp människor kan ha svårt att ta till sig folkuppmaningen »Sätt Sverige i rörelse«, trots vetskapen om att regelbunden lågintensiv motion och muskelträning kan ge stora positiva hälsoeffekter. Vem antar utmaningen att  sätta änkorna i rörelse – och vem bekostar?

  • 143. Grimby, G
    et al.
    Börjesson, Mats
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Jonsdottir, I H
    Schnohr, P
    Thelle, D S
    Saltin, Bengt
    The "Saltin-Grimby Physical Activity Level Scale" and its application to health research.2015In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 25, no Suppl 4, p. 119-125Article in journal (Refereed)
    Abstract [en]

    The use of a four-level questionnaire to assess leisure time physical activity (PA) and its validation is reviewed in this paper. This questionnaire was first published in 1968 and has then been used by more than 600 000 subjects, especially in different population studies in the Nordic countries. A number of modifications to the questionnaire have been published. These are mostly minor changes, such as adding practical examples of activities to illustrate the levels of PA. Some authors have also added duration requirements that were not included for all levels of PA in the original version. The concurrent validity, with respect to aerobic capacity and movement analysis using objective measurements has been shown to be good, as has the predictive validity with respect to various risk factors for health conditions and for morbidity and mortality.

  • 144. Haglind, Charlotte
    et al.
    Ask, Sara
    von Döbeln, Ulrika
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Stenlid, Maria
    Nordenström, Anna
    Energy expenditure and lipid metabolism in very long-chain Acyl-CoA dehydrogenase (VLCAD) deficiency2015In: Molecular Genetics and Metabolism (ISSN 1096-7192), 2015, Vol. 114, no 3, p. 333-333Conference paper (Refereed)
  • 145.
    Hallgren, Mats
    et al.
    Karolinska institutet.
    Andersson, Victoria
    Center for Psychiatric Research, Stockholm.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.
    Andréasson, Sven
    Karolinska institutet.
    Physical activity as treatment for alcohol use disorders (FitForChange): study protocol for a randomized controlled trial.2018In: Trials, ISSN 1745-6215, E-ISSN 1745-6215, Vol. 19, no 1, article id 106Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Help-seeking for alcohol use disorders (AUDs) is low and traditional treatments are often perceived as stigmatizing. Physical activity has positive effects on mental and physical health which could benefit this population. We propose to compare the effects of aerobic training, yoga, and usual care for AUDs in physically inactive Swedish adults.

    METHODS: This is a three-group, parallel, single-blind, randomized controlled trial (RCT). In total, 210 adults (aged 18-75 years) diagnosed with an AUD will be invited to participate in a 12-week intervention. The primary study outcome is alcohol consumption measure by the Timeline Follow-back method and the Alcohol Use Disorders Identification Test (AUDIT). Secondary outcomes include: depression, anxiety, perceived stress, sleep quality, physical activity levels, fitness, self-efficacy, health-related quality of life, and cognition. Blood samples will be taken to objectively assess heavy drinking, and saliva to measure cortisol. Acute effects of exercise on the urge to drink alcohol, mood, and anxiety will also be assessed.

    DISCUSSION: The treatment potential for exercise in AUDs is substantial as many individuals with the disorder are physically inactive and have comorbid health problems. The study is the first to assess the effects of physical activity as a stand-alone treatment for AUDs. Considerable attention will be given to optimizing exercise adherence. Both the feasibility and treatment effects of exercise interventions in AUDs will be discussed. The Ethical Review Board (EPN) at Karolinska Institutet has approved the study (DNR: 2017/1380-3).

    TRIAL REGISTRATION: German Clinical Trials Register, ID: DRKS00012311. Registered on 26 September 2017.

  • 146. Hallgren, Mats
    et al.
    Herring, Matthew P
    Owen, Neville
    Dunstan, David
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Helgadottir, Björg
    Nakitanda, Olivia Aya
    Forsell, Yvonne
    Exercise, Physical Activity, and Sedentary Behavior in the Treatment of Depression: Broadening the Scientific Perspectives and Clinical Opportunities.2016In: Frontiers in Psychiatry, ISSN 1664-0640, E-ISSN 1664-0640, Vol. 7, article id 36Article in journal (Refereed)
    Abstract [en]

    Research exploring links between exercise and depression now span several decades, yet several clinically relevant research questions remain unanswered. This opinion article briefly describes the status of selected research issues from the exercise depression literature and offer insights into research areas that are currently lacking. We draw particular attention to the potential of research exploring links between sedentary behavior and depression.

  • 147. Hallgren, Mats
    et al.
    Nakitanda, Olivia Aya
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Herring, Matthew P
    Owen, Neville
    Dunstan, David W
    Helgadottir, Björg
    Forsell, Yvonne
    Habitual physical activity levels predict treatment outcomes in depressed adults: A prospective cohort study.2016In: Preventive Medicine, ISSN 0091-7435, E-ISSN 1096-0260, Vol. 88, p. 53-58Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: Exercise is an efficacious stand-alone therapy for mild-to-moderate depression, but little is known about the influence of physical activity levels on responses to depression treatment. This study aimed to prospectively assess the association between self-reported habitual physical activity levels and depression severity following a 12-week intervention.

    METHOD: 629 adults (75% women; aged 18-71years) with mild-to-moderate depression were recruited from primary care centres across Sweden and treated for 12weeks. The interventions included internet-based cognitive behavioural therapy (ICBT) and 'usual care' (CBT or supportive counselling). One third of all participants were taking anti-depressant medication. The primary outcome was the change in depression severity assessed using the Montgomery-Åsberg Depression Rating Scale (MADRS). Habitual physical activity levels were self-rated and based on the estimated frequency, duration and intensity of total physical activity, including planned exercise, 'during a typical week'. Prospective associations were explored using linear regression models (percentage change) with 95% confidence intervals (CI's).

    RESULTS: Following adjustment for relevant covariates, high levels of habitual physical activity were associated with larger relative reductions in depression severity compared to low physical activity (β=-9.19, 95% CI=-18.46, -0.09, p=0.052) and moderate physical activity (β=-10.81, 95% CI=-21.09, -0.53, p<0.05), respectively.

    CONCLUSION: Adults who routinely engage in high levels of physical activity respond more favourably to CBT-focused depression treatments than adults who engage in low-to-moderate levels of activity. The optimal level of physical activity associated with reductions in depression severity corresponds to consensus recommendations for maximizing general health. One limitation is the use of self-reported physical activity data.

  • 148.
    Hassmén, Peter
    et al.
    Stockholms universitet.
    Blomstrand, Eva
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Eva Blomstrand's research group.
    Ekblom, Björn
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
    Newsholme, E A
    Branched-chain amino acid supplementation during 30-km competitive run: mood and cognitive performance.1994In: Nutrition (Burbank, Los Angeles County, Calif.), ISSN 0899-9007, E-ISSN 1873-1244, Vol. 10, no 5, p. 405-10Article in journal (Refereed)
    Abstract [en]

    It has been suggested that an elevated concentration of the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) in specific areas of the brain may contribute to the development of central/mental fatigue during and after sustained exercise. Supplementation with branched-chain amino acids (BCAAs) should prevent the exercise-induced increase in the plasma concentration ratio of free tryptophan to other large neutral amino acids (including BCAAs) and thereby prevent an elevation in the level of 5-HT in the brain. In this study, subjects were given either a mixture of BCAAs in a carbohydrate solution or a placebo drink that contained only carbohydrates during a 30-km cross-country race. Several tasks to measure cognitive performance were performed before and after the race. When subjects were supplied with BCAAs, their performance in the different parts of the color-word test (words, colors and color words) was improved by an average of 3-7% (p < 0.05) after exercise, whereas there was no difference in performance before and after exercise in the subjects who were given the placebo. Furthermore, the experimental group, supplied with BCAAs, maintained their performance in the shape-rotation and figure-identification tasks, whereas an impairment in performance in these tests by 25% (p < 0.05) and 15% (p < 0.05), respectively, was found in the subjects who received the placebo. Thus, BCAA supplementation seemed to have an effect on the more complex tasks, whereas no effect could be detected on the less demanding tasks. However, an intake of BCAAs during exercise modified only slightly the exercise-induced changes in mood.

  • 149. Helgadottir, B.
    et al.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Forsell, Y.
    Physical Activity Patterns of People Affected by Depressive and Anxiety Disorders: A Descriptive Study2014In: Journal of Mental Health Policy and Economics, 17, (Suppl 1), S9., 2014, Vol. 17, no Suppl 1, p. S9-Conference paper (Refereed)
  • 150.
    Helgadottir, Björg
    et al.
    Karolinska Institutet.
    Ekblom, Örjan
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group.
    Forsell, Yvonne
    Karolinska Insitutet.
    Impact of expectations on the effects of exercise on psychological distress2014In: American Journal of Health Behavior, ISSN 1087-3244, E-ISSN 1945-7359, Vol. 38, no 5, p. 560-565Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE:

    To evaluate the influence of expectations on effectiveness of exercise in reducing psychological distress.

    METHOD:

    Data came from a Swedish longitudinal population-based study consisting of 4631 people aged 20-64 years. Psychological distress was measured with the Major Depressive Inventory. Expectations (positive expectations or indifference) towards exercise were combined with exercise (regular exercise: yes or no).

    RESULTS:

    Indifferent non-exercisers had increased risk of psychological distress. Regular exercisers who were indifferent towards exercise as a self-help method were less likely to be psychologically distressed compared to exercisers with positive expectations.

    CONCLUSION:

    The results encourage systematic use of exercise in prevention and rehabilitation of persons suffering from psychological distress. People's personal expectations might not be needed for treatment effect.

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