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The influence of exercise on the insulin-like growth factor axis in oncology: physiological basis, current and future perspectives.
School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's and Mats Börjesson's research group. School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.ORCID iD: 0000-0002-5140-9098
School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.
School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.
2016 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 25, no 2, 239-249 p.Article in journal (Refereed) Published
Abstract [en]

Exercise and physical activity have been shown to reduce the risk of many common cancers and strongly influence tumour biology. A cause-effect mechanism explaining this relationship is dependent on cellular pathways that can influence tumour growth and are exercise-responsive. The insulin-like growth factor (IGF) axis is reported to promote the development and progression of carcinomas through cellular signalling in cancerous tissues. This review summarises the physiological basis of the role of the IGF axis in oncology and the influence of exercise on this process. We examined the effects of exercise prescription on the IGF axis in cancer survivors by evaluating the current scope of the literature. The current research demonstrates a remarkable heterogeneity and inconsistency in the responses of the IGF axis to exercise in breast, prostate and colorectal cancer survivors. Finally, this review presents an in-depth exploration of the physiological basis and mechanistic underpinnings of the seemingly disparate relationship between exercise and the IGF axis in oncology. Whilst there is currently insufficient evidence to categorise the effects of exercise prescription on the IGF axis in cancer survivors, the inconsistency of results suggests a multifaceted relationship, the complexities of which are considered in this review.

Place, publisher, year, edition, pages
2016. Vol. 25, no 2, 239-249 p.
National Category
Medical and Health Sciences
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-4264DOI: 10.1158/1055-9965.EPI-15-0406ISI: 000372173000003PubMedID: 26677213OAI: oai:DiVA.org:gih-4264DiVA: diva2:885287
Available from: 2015-12-18 Created: 2015-12-18 Last updated: 2016-12-16Bibliographically approved

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