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Acute exercise during starvation improves insulin sensitivity and increases mitochondrial FA oxidation
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Research group for Mitokondriell funktion och metabolisk kontroll.
Institutionen för Fysiologi och Farmakologi, Karolinska Institutet.
Swedish School of Sport and Health Sciences, GIH.ORCID iD: 0000-0001-9040-2158
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Research group for Mitokondriell funktion och metabolisk kontroll.
2012 (English)Conference paper, Published paper (Other academic)
Abstract [en]

Aim: To investigate if exercise can reverse starvation-induced insulin resistance and to elucidate the mechanism. Methods: Nine subjects underwent 87 h of starvation with (EX) or without (NE) one exercise session at the end. Before and after starvation (3 h post-exercise) subjects underwent an intravenous glucose tolerance test and muscle biopsy. Results: Insulin sensitivity decreased after starvation (NE) but increased after exercise (EX). Glycogen stores were reduced and plasma FA and β-Hydroxybutyrate increased in both conditions. Mitochondrial respiration with FA substrate increased in EX but was unchanged in NE. RCR and mitochondrial ROS production decreased in both conditions. Phosphorylation of Acetyl-CoA carboxylase (ACC) and Akt substrate of 160 kDA (AS160) proteins increased in EX. Conclusion: Exercise improves starvation induced insulin resistance, probably by increased mitochondrial FA oxidation, reduced glycogen stores and alterations in signaling proteins involved in glucose uptake and FA metabolism.

Place, publisher, year, edition, pages
2012.
National Category
Medical and Health Sciences
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-2600OAI: oai:DiVA.org:gih-2600DiVA: diva2:581593
Conference
15th International Biochemistry of Exercise Congress (IBEC) in Stockholm, Sweden, June 17-21, 2012
Available from: 2013-01-02 Created: 2013-01-02 Last updated: 2016-08-10Bibliographically approved

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Frank, PerAndersson, EvaSahlin, Kent

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CiteExportLink to record
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