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Plasma IL-6 concentration during ultra-endurance exercise
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.ORCID iD: 0000-0002-0642-4838
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.ORCID iD: 0000-0002-4030-5437
2011 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 111, no 6, 1081-1088 p.Article in journal (Refereed) Published
Abstract [en]

Interleukin 6 (IL-6) response was studied during two ultra endurance events – one laboratory 24 h protocol (9 men) with exercise intensity set to 60 % of VO2max and one Adventure Race over 6 days (12 men/6 women) with a self-selected race pace, including rests, of about 38 % of VO2max. In the 24 h protocol IL-6 level was elevated from 0.76 ± 0.48 pg mL-1 at rest to 7.16 ± 2.70 pg mL-1 at 6 h, and increased further to 10.58 ± 1.04 pg mL-1 at 12 h, but remained thereafter unchanged at 24 h, (10.89±0.36 pg mL-1). All participants had nearly identical values at 12 and 24 h, supporting intensity as main determinant in the IL-6 response since exercise duration did not increase IL-6 level after 12 h. Possible confounding factors do not seem to influence the IL-6 concentration during the longer races (>12h), but might very well do so during shorter exercise bouts. In the 6-day race IL-6 increased from rest to 24 h, but thereafter there was no change in plasma IL-6 value until the end of the race (140 h). There was no elevation of TNF-α in any of the protocols, suggesting that the competitors were free from systemic inflammation. During endurance exercise lasting >12 h intensity and not duration is the main determinant of the IL-6 response, while during shorter exercise bouts both intensity and duration contribute to the accumulation of IL-6 in plasma.

Place, publisher, year, edition, pages
2011. Vol. 111, no 6, 1081-1088 p.
Keyword [en]
Cytokine, immune response, TNF-α, adventure race, endurance
National Category
Physiology Sport and Fitness Sciences
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-1505DOI: 10.1007/s00421-010-1737-7OAI: oai:DiVA.org:gih-1505DiVA: diva2:371267
Projects
Physiology of Adventure Racing
Available from: 2010-11-19 Created: 2010-11-19 Last updated: 2017-12-12Bibliographically approved

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Wallberg, LinneaMattsson, C. MikaelEnqvist, Jonas K.Ekblom, Björn
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