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Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide.
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Eva Blomstrand's research group.ORCID iD: 0000-0002-6537-042X
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1998 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 249, no 2, 512-6 p.Article in journal (Refereed) Published
Abstract [en]

Strips of rat soleus muscle were incubated in media containing a superoxide generating system and/or the nitric oxide donor sodium nitroprusside (SNP) before the maximal catalytic activities of aconitase, citrate synthase, and oxoglutarate dehydrogenase were measured. The maximal activities of aconitase and oxoglutarate dehydrogenase were both decreased by 25-30% by superoxide anions; however, only the maximal activity of aconitase was decreased, by approximately 50%, by incubation of muscles with SNP. Furthermore, when both superoxide and NO were present in the medium, aconitase activity was decreased by 70%. The maximal activity of citrate synthase was not affected by any of the treatments. This is the first time that superoxide anions or NO has been shown to inactivate aconitase and oxoglutarate dehydrogenase in skeletal muscle. It is suggested that these effects may be responsible for some alterations in skeletal muscle metabolism, and these possibilities are discussed.

Place, publisher, year, edition, pages
1998. Vol. 249, no 2, 512-6 p.
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:gih:diva-1489DOI: 10.1006/bbrc.1998.9171PubMedID: 9712727OAI: oai:DiVA.org:gih-1489DiVA: diva2:369364
Available from: 2010-11-10 Created: 2010-11-10 Last updated: 2016-06-15Bibliographically approved

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