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Extreme values of cardiac peptide NT-proBNP after ultra-endurance exercise in healthy athletes
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.ORCID iD: 0000-0002-0642-4838
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.
Karolinska Institutet.
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Björn Ekblom's research group.ORCID iD: 0000-0002-4030-5437
2010 (English)In: Book of Abstracts of the 15th Annual Congress of the European College of Sport Science – 23-26 June 2010 Antalya - Turkey.: Sport Science: Where the cultures meet / [ed] Korkusuz, F., Ertan, H., Tsolakidis, E., 2010, 35-36 p.Conference paper, (Other academic)
Abstract [en]

Introduction: In clinical medicine, natriuretic peptides, including N-terminal B-type natriuretic peptide (NT-proBNP), are used to detect increased myocardial wall tension in conditions such as heart failure. Tachycardia, arrhythmias and physical exercise may also increase these peptides. The clinical reference value is <100 ng/l, and in clinical practice values >300 ng/l are a strong indicators of heart failure, and values >5000 ng/l highly significant for mortality within 3 months.

Methods: We examined the levels of NT-proBNP after ultra-endurance exercise, and also made an attempt to relate NT-proBNP to performance. The subjects (12 males and 3 females) participated in the Adventure Racing World Championship, a 5-6 days non-stop competition open for mixed gender team of four athletes. They were all healthy, well-trained athletes with experience from several years of competitions at international elite level. Blood samples for determination of NT-proBNP were drawn before exercise (Pre-Ex), at the end of the race (End-Ex) and 24 hours after exercise (Post-Ex). Each athlete rated his/her own performance at the end of the race (i.e. the last 12 hours) on a scale from 1 (good, stronger than teammates), 2 (intermediate) and 3 (poor, got towed in, needed help from teammates). In addition, each athlete was also rated according to the same scale by the other three members of his/her team. Thereafter the four rates were pooled. Note that the rating is in relation to the team rather than the result of the competition.

Results: The average exercise duration was approx. 150 hours, and the calculated average work intensity was 40 % (in percent of respective VO2peak), including time for rest, change of equipment, and food intake. The levels of NT-proBNP increased from 31 ± 14 (10-56) [mean ± SD (min-max)] at Pre-Ex to 487 ± 648 (52-2480) at End-Ex. At Post-Ex the corresponding levels were 224 ± 219 (12-634). At End-Ex seven subjects had NT-proBNP below the reference value. The rated performance for four of them was 1, and the remaining three were rated as 2. Three of the subjects had markedly higher levels than previously reported (>900 ng/l) and they were rated 3, 3 and 2, respectively.

Discussion: Extreme levels of NT-proBNP, up to 2500 ng/l, are present after ultra-endurance exercise in healthy athletes without any clinical signs or symptoms of heart failure. On the other hand, these extreme values may be an indicator of cardiac fatigue, previously described after endurance exercise. Furthermore, in this study high levels of NT-proBNP seem to be associated with decreased exercise performance.

Place, publisher, year, edition, pages
2010. 35-36 p.
National Category
Physiology
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-1233ISBN: 978-605-61427-0-3 (print)OAI: oai:DiVA.org:gih-1233DiVA: diva2:327297
Conference
15th Annual Congress of the European College of Sport Science
Projects
Physiology of Adventure Racing
Available from: 2010-06-28 Created: 2010-06-28 Last updated: 2017-03-31Bibliographically approved

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