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Microdialysis of rat skeletal muscle and adipose tissue: dynamics of the interstitial glucose pool.
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.ORCID iD: 0000-0001-8161-5610
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences.
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1994 (English)In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 151, no 2, 249-60 p.Article in journal (Refereed) Published
Abstract [en]

Microdialysis was evaluated as a method for studying glucose metabolism in skeletal muscle. Dialysis probes (0.5 x 10 mm) were perfused at 0.5 or 1.0 microliter min-1. Based upon perfusion with glucose, the muscle interstitial glucose concentration was estimated to be 6.9 +/- 0.3 mM (n = 14), which was not significantly different from the blood glucose level. With insulin infusion (1200 mU kg-1 body wt i.v.), the insulin-induced change in the glucose concentration of the interstitial space of muscle was of equal magnitude to that of blood and adipose tissue. In spite of this, when the perfusion medium was not supplemented with glucose, the glucose concentration decreased more in skeletal muscle dialysates (to 36.7 +/- 4.9% of the initial level) than in blood (to 29.7 +/- 5.0%) but less than in adipose tissue (to 17.7 +/- 4.9% of the initial level) (P < 0.05). The results indicate that these differences are due to tissue-specific differences in the dynamic balance between the supply to, and removal from, the interstitial glucose pool. This balance is revealed as a result of the constant glucose drainage by the microdialysis probe. The present results show that, in skeletal muscle, increases in glucose uptake occur with a concomitant increase in tissue blood flow as revealed by the microdialysis ethanol technique, whereas in adipose tissue the glucose uptake increases in the absence of a corresponding increase in blood flow.

Place, publisher, year, edition, pages
1994. Vol. 151, no 2, 249-60 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:gih:diva-1079PubMedID: 7942061OAI: oai:DiVA.org:gih-1079DiVA: diva2:284675
Available from: 2010-01-08 Created: 2010-01-08 Last updated: 2017-03-01Bibliographically approved
In thesis
1. Microdialysis sampling from skeletal muscle and adipose tissue with special reference to the effects of insulin on tissue blood flow and glucose metabolism
Open this publication in new window or tab >>Microdialysis sampling from skeletal muscle and adipose tissue with special reference to the effects of insulin on tissue blood flow and glucose metabolism
1998 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Stockholm: Norstedts Tryckeri AB, 1998. 56 p.
Keyword
microdialysis, insulin, skeletal muscle, adipose tissue, glucose, amino acids
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:gih:diva-1082 (URN)91-628-3050-3 (ISBN)
Public defence
1998-06-12, Aulan, GIH, Lidingövägen 1, Stockholm, 09:00 (English)
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Supervisors
Available from: 2010-01-08 Created: 2010-01-08 Last updated: 2017-03-01Bibliographically approved

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