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Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport.
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Eva Blomstrand's research group.ORCID iD: 0000-0002-6537-042X
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2001 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 90, no 1, 29-34 p.Article in journal (Refereed) Published
Abstract [en]

Vastus lateralis muscle biopsies were obtained from endurance-trained (running approximately 50 km/wk) and untrained (no regular physical exercise) men, and the expression of an array of insulin-signaling intermediates was determined. Expression of insulin receptor and insulin receptor substrate-1 and -2 was decreased 44% (P < 0.05), 57% (P < 0.001), and 77% (P < 0.001), respectively, in trained vs. untrained muscle. The downstream signaling target, Akt kinase, was not altered in trained subjects. Components of the mitogenic signaling cascade were also assessed. Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase expression was 190% greater (P < 0.05), whereas p38 mitogen-activated protein kinase expression was 32% lower (P < 0.05), in trained vs. untrained muscle. GLUT-4 protein expression was twofold higher (P < 0.05), and the GLUT-4 vesicle-associated protein, the insulin-regulated aminopeptidase, was increased 4.7-fold (P < 0. 05) in trained muscle. In conclusion, the expression of proteins involved in signal transduction is altered in skeletal muscle from well-trained athletes. Downregulation of early components of the insulin-signaling cascade may occur in response to increased insulin sensitivity associated with endurance training.

Place, publisher, year, edition, pages
2001. Vol. 90, no 1, 29-34 p.
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Medical and Health Sciences
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URN: urn:nbn:se:gih:diva-952PubMedID: 11133890OAI: oai:DiVA.org:gih-952DiVA: diva2:236626
Available from: 2009-09-24 Created: 2009-09-21 Last updated: 2016-06-15Bibliographically approved

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