Gymnastik- och idrottshögskolan, GIH

Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity
Karolinska Inst, Dept Oncol Pathol, CCK, R8 01, S-17176 Stockholm, Sweden.
Karolinska Inst, Karolinska Hosp Solna, Dept Clin Neurosci, CMM, S-17176 Stockholm, Sweden.
Karolinska Inst, Dept Oncol Pathol, CCK, R8 01, S-17176 Stockholm, Sweden.
Uppsala universitet, Science for Life Laboratory, SciLifeLab.
Show others and affiliations
2018 (English)In: iScience, E-ISSN 2589-0042, Vol. 9, p. 71-83Article in journal (Refereed) Published
Abstract [en]

High-grade gliomas (HGGs) are the most aggressive and invasive primary brain tumors. The platelet-derived growth factor (PDGF) signaling pathway drives HGG progression, and enhanced expression of PDGF receptors (PDGFRs) is a well-established aberration in a subset of glioblastomas (GBMs). PDGFRA is expressed in glioma cells, whereas PDGFRB is mostly restricted to the glioma-associated stroma. Here we show that the spatial location of TAMMs correlates with the expansion of a subset of tumor cells that have acquired expression of PDGFRB in both mouse and human low-grade glioma and HCGs. Furthermore, M2-polarized microglia but not bone marrow (BM)-derived macrophages (BMDMs) induced PDGFRB expression in glioma cells and stimulated their migratory capacity. These findings illustrate a heterotypic cross-talk between microglia and glioma cells that may enhance the migratory and invasive capacity of the latter by inducing PDGFRB.

Place, publisher, year, edition, pages
2018. Vol. 9, p. 71-83
National Category
Cell and Molecular Biology Cancer and Oncology
Identifiers
URN: urn:nbn:se:gih:diva-7942DOI: 10.1016/j.isci.2018.10.011ISI: 000454331400007PubMedID: 30384135OAI: oai:DiVA.org:gih-7942DiVA, id: diva2:1812657
Funder
Swedish Cancer Society, 2016/825Swedish Cancer Society, CAN 2016/791Swedish Research Council, 2013-5982Swedish Childhood Cancer Foundation, NCP2015-0064Swedish Childhood Cancer Foundation, NC2014-0046Swedish Childhood Cancer Foundation, PR2014-0154Wallenberg FoundationsAvailable from: 2023-11-16 Created: 2023-11-16 Last updated: 2023-11-16

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedFulltext

Authority records

Bolin, SaraJiang, YiwenSwartling, Fredrik J.Uhrbom, Lene

Search in DiVA

By author/editor
Bolin, SaraJiang, YiwenSwartling, Fredrik J.Uhrbom, Lene
In the same journal
iScience
Cell and Molecular BiologyCancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 18 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf