Gymnastik- och idrottshögskolan, GIH

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Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training.
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics.ORCID iD: 0000-0002-7743-9295
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics.ORCID iD: 0000-0001-8314-7814
Linnaeus University, Kalmar, Sweden..
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics. (Student)
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2023 (English)In: Redox Biology, ISSN 0090-7324, E-ISSN 2213-2317, Vol. 67, article id 102873Article in journal (Refereed) Published
Abstract [en]

Oxidative stress plays a vital role for the adaptive responses to physical training. However, excessive oxidative stress can precipitate cellular damage, necessitating protective mechanisms to mitigate this effect. Glucosinolates, found predominantly in cruciferous vegetables, can be converted into isothiocyanates, known for their antioxidative properties. These compounds activate crucial antioxidant defence pathways and support mitochondrial function and protein integrity under oxidative stress, in both Nrf2-dependent and independent manners. We here administered glucosinolate-rich broccoli sprouts (GRS), in a randomized double-blinded cross-over fashion to 9 healthy subjects in combination with daily intense exercise training for 7 days. We found that exercise in combination with GRS significantly decreased the levels of carbonylated proteins in skeletal muscle and the release of myeloperoxidase into blood. Moreover, it lowered lactate accumulation during submaximal exercise, and attenuated the severe nocturnal hypoglycaemic episodes seen during the placebo condition. Furthermore, GRS in combination with exercise improved physical performance, which was unchanged in the placebo condition.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 67, article id 102873
National Category
Sport and Fitness Sciences
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-7791DOI: 10.1016/j.redox.2023.102873ISI: 001074895800001PubMedID: 37688976OAI: oai:DiVA.org:gih-7791DiVA, id: diva2:1797461
Funder
Ekhaga FoundationSwedish National Centre for Research in Sports
Note

This study was funded by grants from Ekhagastiftelsen, Swedish Research Council for Sport Science and Sydgrönt Ekonomisk Förening.

Available from: 2023-09-14 Created: 2023-09-14 Last updated: 2023-10-24

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Flockhart, MikaelNilsson, LinaApro, WilliamSundqvist, Michaela LLarsen, Filip J

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