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Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration of young women.
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.ORCID iD: 0000-0002-3500-2896
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Eva Blomstrand's research group.ORCID iD: 0000-0003-1942-2919
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Eva Blomstrand's research group.ORCID iD: 0000-0003-3747-0148
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.ORCID iD: 0000-0002-5574-4408
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2020 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601Article in journal (Refereed) Epub ahead of print
Abstract [en]

It is well established that testosterone administration induces muscle fiber hypertrophy and myonuclear addition in men, however, it remains to be determined whether similar morphological adaptations can be achieved in women. The aim of the present study was therefore to investigate whether exogenously administered testosterone alters muscle fiber morphology in skeletal muscle of young healthy, physically active women. Thirty-five young (20-35 years), recreationally trained women were randomly assigned to either 10-week testosterone administration (10 mg daily) or placebo. Before and after the intervention, hormone concentrations and body composition were assessed, and muscle biopsies were obtained from the vastus lateralis. Fiber type composition, fiber size, satellite cell- and myonuclei content, as well as muscle capillarization were assessed in a fiber type-specific manner using immunohistochemistry. Following the intervention, testosterone administration elevated serum testosterone concentration (5.1-fold increase, P=0.001), and induced significant accretion of total lean mass (+1.9%, P=0.002) and leg lean mass (+2.4%, P=0.001). On the muscle fiber level, testosterone increased mixed fiber cross-sectional area (+8.2%, P=0.001), an effect primarily driven by increases in type II fiber size (9.2%, P=0.006). Whereas myonuclei content remained unchanged, a numerical increase (+30.8%) was found for satellite cells associated with type II fibers in the Testosterone group. In parallel with fiber hypertrophy, testosterone significantly increased capillary contacts (+7.5%, P=0.015) and capillary-to-fiber ratio (+9.2%, P=0.001) in type II muscle fibers. The current study provides novel insight into fiber type-specific adaptations present already after 10 weeks of only moderately elevated testosterone levels in women.

Place, publisher, year, edition, pages
American Physiological Society , 2020.
Keywords [en]
androgens, capillarization, myonuclear domain, myonuclei, satellite cells
National Category
Physiology
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-6096DOI: 10.1152/japplphysiol.00893.2019PubMedID: 32191598OAI: oai:DiVA.org:gih-6096DiVA, id: diva2:1416609
Available from: 2020-03-24 Created: 2020-03-24 Last updated: 2020-03-26Bibliographically approved

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The full text will be freely available from 2021-03-19 14:00
Available from 2021-03-19 14:00

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Horwath, OscarApro, WilliamMoberg, MarcusGodhe, ManneHelge, TorbjörnEkblom, MariaEkblom, Björn

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Horwath, OscarApro, WilliamMoberg, MarcusGodhe, ManneHelge, TorbjörnEkblom, MariaEkblom, Björn
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Åstrand Laboratory of Work PhysiologyEva Blomstrand's research groupBjörn Ekblom's research groupLaboratory for Biomechanics and Motor Control
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