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Transcranial contrast-enhanced ultrasound in the rat brain reveals substantial hyperperfusion acutely post-stroke.
University of Tasmania, Hobart, Tasmania, Australia.
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.
University of Tasmania, Hobart, Tasmania, Australia.
Deakin University, Geelong, Victoria, Australia.
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2020 (English)In: Journal of Cerebral Blood Flow and Metabolism, ISSN 0271-678X, E-ISSN 1559-7016, article id 271678X20905493Article in journal (Refereed) Epub ahead of print
Abstract [en]

Direct and real-time assessment of cerebral hemodynamics is key to improving our understanding of cerebral blood flow regulation in health and disease states such as stroke. While a number of sophisticated imaging platforms enable assessment of cerebral perfusion, most are limited either spatially or temporally. Here, we applied transcranial contrast-enhanced ultrasound (CEU) to measure cerebral perfusion in real-time through the intact rat skull before, during and after ischemic stroke, induced by intraluminal filament middle cerebral artery occlusion (MCAO). We demonstrate expected decreases in cortical and striatal blood volume, flow velocity and perfusion during MCAO. After filament retraction, blood volume and perfusion increased two-fold above baseline, indicative of acute hyperperfusion. Adjacent brain regions to the ischemic area and the contralateral hemisphere had increased blood volume during MCAO. We assessed our data using wavelet analysis to demonstrate striking vasomotion changes in the ischemic and contralateral cortices during MCAO and reperfusion. In conclusion, we demonstrate the application of CEU for real-time assessment of cerebral hemodynamics and show that the ischemic regions exhibit striking hyperemia post-MCAO. Whether this post-stoke hyperperfusion is sustained long-term and contributes to stroke severity is not known.

Place, publisher, year, edition, pages
Sage Publications, 2020. article id 271678X20905493
Keywords [en]
Ischemic stroke, cerebral blood flow, contrast-enhanced ultrasound, middle cerebral artery occlusion, rat
National Category
Neurology
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-6045DOI: 10.1177/0271678X20905493ISI: 000514038400001PubMedID: 32063081OAI: oai:DiVA.org:gih-6045DiVA, id: diva2:1395595
Available from: 2020-02-24 Created: 2020-02-24 Last updated: 2020-03-16Bibliographically approved

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Blackwood, Sarah J

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