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Dose-response relationship between exercise load and mitochondrial function
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.ORCID iD: 0000-0002-7743-9295
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Research group for Mitokondriell funktion och metabolisk kontroll.ORCID iD: 0000-0001-8314-7814
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.ORCID iD: 0000-0003-1942-2919
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.ORCID iD: 0000-0002-4030-5437
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2019 (English)Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

Dose-response relationship between exercise load and mitochondrial function

Flockhart M, Nilsson L, Bergman K, Apro W, Ekblom B, Larsen FJ

A dose-dependent relationship exists between exercise load and muscular adaptation. Mitochondria adapt to the increased ATP-demand by alterations in mass and/or quality. How mitochondrial mass and quality changes as a function of exercise load is not well investigated and we have previously found mitochondrial dysfunction after short-term intensive exercise. We therefore aimed to study mitochondrial function by altering exercise load during a three week interval training regimen to understand the dose-response relationship between exercise load and mitochondrial function. We took four muscle biopsies throughout the study, and as expected, mitochondrial function was positively affected during the first two weeks. After the third week, a dramatic mitochondrial dysfunction was evident as mitochondrial intrinsic respiration was reduced by 26% despite a 32% increase in mitochondrial yield. We hereby present evidence of a striking exercise-induced reduction in mitochondrial function after a period of very intense interval training.

Place, publisher, year, edition, pages
2019.
National Category
Cell Biology
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-5932OAI: oai:DiVA.org:gih-5932DiVA, id: diva2:1374366
Conference
Cell Symposia: Exercise Metabolism, May 5-7 2019, Sitges Spain
Funder
Swedish National Centre for Research in SportsAvailable from: 2019-11-29 Created: 2019-11-29 Last updated: 2019-12-09Bibliographically approved

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Flockhart, MikaelNilsson, LinaApro, WilliamEkblom, BjörnLarsen, Filip J

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Flockhart, MikaelNilsson, LinaApro, WilliamEkblom, BjörnLarsen, Filip J
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Åstrand Laboratory of Work PhysiologyResearch group for Mitokondriell funktion och metabolisk kontrollBjörn Ekblom's research group
Cell Biology

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