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Effects of training, detraining, and retraining on strength, hypertrophy, and myonuclear number in human skeletal muscle
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.ORCID iD: 0000-0003-1848-5491
University of Oslo, Norway.
Norwegian School of Sport Sciences, Norway.
University of Oslo, Norway.
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2019 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 126, no 6, p. 1636-1645Article in journal (Refereed) Published
Abstract [en]

Previously trained mouse muscles acquire strength and volume faster than naïve muscles; it has been suggested that this is related to increased myonuclear density. The present study aimed to determine whether a previously strength-trained leg (mem-leg) would respond better to a period of strength training than a previously untrained leg (con-leg). Nine men and 10 women performed unilateral strength training (T1) for 10 weeks, followed by 20 weeks of detraining (DT) and a 5-week bilateral retraining period (T2). Muscle biopsies were taken before and after each training period and analyzed for myonuclear number, fiber volume, and cross-sectional area (CSA). Ultrasound and one repetition of maximum leg extension were performed to determine muscle thickness (MT) and strength. CSA (~17%), MT (~10%), and strength (~20%) increased during T1 in the mem-leg. However, the myonuclear number and fiber volume did not change. MT and CSA returned to baseline values during DT, but strength remained elevated (~60%), supporting previous findings of a long-lasting motor learning effect. MT and strength increased similarly in the mem-leg and con-leg during T2, whereas CSA, fiber volume, and myonuclear number remained unaffected. In conclusion, training response during T2 did not differ between the mem-leg and con-leg. However, this does not discount the existence of human muscle memory since no increase in the number of myonuclei was detected during T1 and no clear detraining effect was observed for cell size during DT; thus, the present data did not allow for a rigorous test of the muscle memory hypothesis.

Place, publisher, year, edition, pages
American Physiological Society , 2019. Vol. 126, no 6, p. 1636-1645
Keywords [en]
CSA, exercise, motor learning, muscle memory, myonuclei
National Category
Sport and Fitness Sciences
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-5716DOI: 10.1152/japplphysiol.00917.2018ISI: 000471217500014PubMedID: 30991013OAI: oai:DiVA.org:gih-5716DiVA, id: diva2:1306301
Available from: 2019-04-23 Created: 2019-04-23 Last updated: 2019-08-14Bibliographically approved

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Psilander, NiklasEkblom, MariaEkblom, Björn

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Åstrand Laboratory of Work PhysiologyLaboratory for Biomechanics and Motor ControlBjörn Ekblom's research group
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