Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The Muscle Fiber Profiles, Mitochondrial Content, and Enzyme Activities of the Exceptionally Well-Trained Arm and Leg Muscles of Elite Cross-Country Skiers
Univ Southem Denmark, SDU Muscle Res Cluster, Dept Sports Sci & Clin Biomech, Odense, Denmark.;Univ British Columbia, Sch Kinesiol, Vancouver, BC, Canada..
Univ Southem Denmark, SDU Muscle Res Cluster, Dept Sports Sci & Clin Biomech, Odense, Denmark..
Univ British Columbia, Sch Kinesiol, Vancouver, BC, Canada..
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.ORCID iD: 0000-0001-5885-2378
Show others and affiliations
2018 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 9, article id 1031Article in journal (Refereed) Published
Abstract [en]

As one of the most physically demanding sports in the Olympic Games, cross-country skiing poses considerable challenges with respect to both force generation and endurance during the combined upper-and lower-body effort of varying intensity and duration. The isoforms of myosin in skeletal muscle have long been considered not only to define the contractile properties, but also to determine metabolic capacities. The current investigation was designed to explore the relationship between these isoforms and metabolic profiles in the arms (triceps brachii) and legs (vastus lateralis) as well as the range of training responses in the muscle fibers of elite cross-country skiers with equally and exceptionally well-trained upper and lower bodies. The proportion of myosin heavy chain (MHC)-1 was higher in the leg (58 +/- 2% [34-69%]) than arm (40 +/- 3% [24-57%]), although the mitochondrial volume percentages [8.6 +/- 1.6 (leg) and 9.0 +/- 2.0 (arm)], and average number of capillaries per fiber [5.8 +/- 0.8 (leg) and 6.3 +/- 0.3 (arm)] were the same. In these comparable highly trained leg and arm muscles, the maximal citrate synthase (CS) activity was the same. Still, 3-hydroxy-acyl-CoA-dehydrogenase (HAD) capacity was 52% higher (P < 0.05) in the leg compared to arm muscles, suggesting a relatively higher capacity for lipid oxidation in leg muscle, which cannot be explained by the different fiber type distributions. For both limbs combined, HAD activity was correlated with the content of MHC-1 (r(2) = 0.32, P = 0.011), whereas CS activity was not. Thus, in these highly trained cross-country skiers capillarization of and mitochondrial volume in type 2 fiber can be at least as high as in type 1 fibers, indicating a divergence between fiber type pattern and aerobic metabolic capacity. The considerable variability in oxidative metabolism with similar MHC profiles provides a new perspective on exercise training. Furthermore, the clear differences between equally well-trained arm and leg muscles regarding HAD activity cannot be explained by training status or MHC distribution, thereby indicating an intrinsic metabolic difference between the upper and lower body. Moreover, trained type 1 and type 2A muscle fibers exhibited similar aerobic capacity regardless of whether they were located in an arm or leg muscle.

Place, publisher, year, edition, pages
2018. Vol. 9, article id 1031
Keywords [en]
limb muscles, fiber plasticity, training, capillarization, mitochondria, IMCL, cross-country skiing
National Category
Sport and Fitness Sciences
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-5371DOI: 10.3389/fphys.2018.01031ISI: 000440602700001PubMedID: 30116201OAI: oai:DiVA.org:gih-5371DiVA, id: diva2:1239757
Available from: 2018-08-17 Created: 2018-08-17 Last updated: 2018-08-20

Open Access in DiVA

fulltext(2363 kB)12 downloads
File information
File name FULLTEXT01.pdfFile size 2363 kBChecksum SHA-512
9fbaff1b503ef4b386fba040712d2ea52f73d0b04c497521f52ea06b11986ce533fc8443b95c906ed142f345133ea0b9759c8bac0bcfb78630b966d563435212
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Söderlund, Karin

Search in DiVA

By author/editor
Söderlund, Karin
By organisation
Björn Ekblom's research group
In the same journal
Frontiers in Physiology
Sport and Fitness Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 12 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 49 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf