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Twelve-week physical exercise does not have a long-lasting effect on kynurenines in plasma of depressed patients
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.ORCID iD: 0000-0001-6058-4982 
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2017 (English)In: Neuropsychiatric Disease and Treatment, ISSN 1176-6328, E-ISSN 1178-2021, Vol. 13, 967-972 p.Article in journal (Refereed) Published
Abstract [en]

Background: Physical exercise has well-characterized positive effects on depressive symptoms. The underlying biologic mechanisms are, however, far from established. A recently discovered mechanism has linked the enhanced conversion of kynurenine to kynurenic acid (KYNA) to an increased resilience toward stress-induced depression in mice. The aim of this study was to translate these findings to humans.

Materials and methods: Kynurenine and KYNA levels were measured by high-performance liquid chromatography in plasma samples from 117 patients affected by mild-to-moderate depression before and within a week after a 12-week training period at three different intensities. The patients were part of the Regassa study.

Results: No differences in plasma levels of kynurenine and KYNA or in their ratio could be detected between before and after training. No effect of the intensity group could be observed. No correlation with the improvement in cardiovascular fitness (Åstrand score) or the improvement in mood (Montgomery Åsberg Depression Rating Scale score) could be observed.

Limitations: As the Regassa study is based on an intention-to-treat protocol, the exact time and the exact intensity of the physical exercise are not known. Analyses of pulse data as well as personal interviews, however, were used to control the exercise protocols. Furthermore, the observations reflect chronic changes.

Conclusion: Physical exercise positively affects mood and cardiovascular fitness, but does not lead to long-lasting changes in plasma levels of kynurenine and KYNA in patients affected by mild-to-moderate depression.

Place, publisher, year, edition, pages
Dove Medical Press , 2017. Vol. 13, 967-972 p.
Keyword [en]
Kynurenine pathway, kynurenine, kynurenic acid, depression, physical exercise, Neurosciences. Biological psychiatry. Neuropsychiatry, Internal medicine, Medicine
National Category
Psychiatry
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-4855DOI: 10.2147/NDT.S131746ISI: 000397975100001OAI: oai:DiVA.org:gih-4855DiVA: diva2:1088277
Available from: 2017-04-12 Created: 2017-04-12 Last updated: 2017-04-28

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Publisher's full texthttps://www.dovepress.com/twelve-week-physical-exercise-does-not-have-a-long-lasting-effect-on-k-peer-reviewed-article-NDT

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