Gymnastik- och idrottshögskolan, GIH

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Elevated heart rate and decreased muscle endothelial nitric oxide synthase in early development of insulin resistance.
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics. (Åstrand Laboratory)ORCID iD: 0000-0002-4853-6627
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics.ORCID iD: 0000-0001-8095-0628
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics.
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics.ORCID iD: 0000-0002-0081-4691
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2024 (English)In: American Journal of Physiology. Endocrinology and Metabolism, ISSN 0193-1849, E-ISSN 1522-1555Article in journal (Refereed) Epub ahead of print
Abstract [en]

Insulin resistance (IR) is a risk factor for the development of several major metabolic diseases. Muscle fiber composition is established early in life and is associated with insulin sensitivity. Hence, muscle fiber composition was used to identify early defects in the development of IR in healthy young individuals in the absence of clinical manifestations. Biopsies were obtained from the thigh muscle, followed by an intravenous glucose tolerance test. Indices of insulin action were calculated and cardiovascular measurements, analyses of blood and muscle were performed. Whole-body insulin sensitivity (SIgalvin) was positively related to expression of type I muscle fibers (r=0.49; P<0.001) and negatively related to resting heart rate (HR, r=-0.39; P<0.001), which was also negatively related to expression of type I muscle fibers (r=-0.41; P<0.001). Muscle protein expression of endothelial nitric oxide synthase (eNOS), whose activation results in vasodilation, was measured in two subsets of subjects expressing a high percentage of type I fibers (59±6%; HR = 57±9 beats/min; SIgalvin = 1.8±0.7 units) or low percentage of type I fibers (30±6%; HR = 71±11; SIgalvin = 0.8±0.3 units; P<0.001 for all variables vs. first group). eNOS expression was: 1. higher in subjects with high type I expression; 2. almost two-fold higher in pools of type I vs. II fibers; 3. only detected in capillaries surrounding muscle fibers; and 4. linearly associated with SIgalvin. These data demonstrate that an altered function of the autonomic nervous system and a compromised capacity for vasodilation in the microvasculature occur early in the development of IR.

Place, publisher, year, edition, pages
American Physiological Society, 2024.
Keywords [en]
Heart rate, Insulin resistance, Muscle fiber composition, Nitric oxide synthase
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Physiology Sport and Fitness Sciences
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-8276DOI: 10.1152/ajpendo.00148.2024PubMedID: 38836779OAI: oai:DiVA.org:gih-8276DiVA, id: diva2:1866467
Available from: 2024-06-07 Created: 2024-06-07 Last updated: 2024-06-07

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Blackwood, Sarah JTischer, DominikPontén, MarjanEdman, SebastianHorwath, OscarApro, WilliamEkblom, MariaMoberg, MarcusKatz, Abram

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Blackwood, Sarah JTischer, DominikPontén, MarjanEdman, SebastianHorwath, OscarApro, WilliamEkblom, MariaMoberg, MarcusKatz, Abram
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Department of Physiology, Nutrition and BiomechanicsDepartment of Physical Activity and Health
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American Journal of Physiology. Endocrinology and Metabolism
PhysiologySport and Fitness Sciences

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