Gymnastik- och idrottshögskolan, GIH

Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Cardiorespiratory fitness and the association with galectin-1 in middle-aged individuals.
Center for Health and Performance, Department of Food and Nutrition, and Sport Science, Faculty of Education, University of Gothenburg, Gothenburg, Sweden.
Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Gymnastik- och idrottshögskolan, GIH, Institutionen för fysisk aktivitet och hälsa.ORCID-id: 0000-0001-6058-4982
Gymnastik- och idrottshögskolan, GIH, Institutionen för fysisk aktivitet och hälsa.ORCID-id: 0000-0002-3901-7833
Vise andre og tillknytning
2024 (engelsk)Inngår i: PLOS ONE, E-ISSN 1932-6203, Vol. 19, nr 4, artikkel-id e0301412Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Galectin-1 plays a functional role in human metabolism and the levels are altered in obesity and type 2 diabetes (T2D). This study investigates the association of cardiorespiratory fitness (CRF) with galectin-1 and the interconnection with body fatness. Cross-sectional data from the Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot was analyzed, including a sample of 774 middle-aged individuals. A submaximal cycle ergometer test was used to estimate CRF as an indirect measure of the physical activity (PA) level. Serum-galectin-1 concentration was determined from venous blood collected after an overnight fast. Body mass index (BMI) was used as an indirect measure of body fatness. CRF was significantly associated with galectin-1, when controlled for age and sex (regression coefficient (regr coeff) = -0.29, p<0.001). The strength of the association was attenuated when BMI was added to the regression model (regr coeff = -0.09, p = 0.07), while the association between BMI and galectin-1 remained strong (regr coeff = 0.40, p<0.001). CRF was associated with BMI (regr coeff = -0.50, p<0.001). The indirect association between CRF and galectin-1 through BMI (-0.50 x 0.40) contributed to 69% of total association (mediation analysis). In group comparisons, individuals with low CRF-high BMI had the highest mean galectin-1 level (25 ng/ml), while individuals with high CRF-low BMI had the lowest level (21 ng/ml). Intermediate levels of galectin-1 were found in the low CRF-low BMI and high CRF-high BMI groups (both 22 ng/ml). The galectin-1 level in the low CRF-high BMI group was significantly different from the other three groups (P<0.001). In conclusion, galectin-1 is associated with CRF as an indirect measure of the PA level through interconnection with body fatness. The size of the association is of clinical relevance.

sted, utgiver, år, opplag, sider
Public Library of Science (PLoS), 2024. Vol. 19, nr 4, artikkel-id e0301412
HSV kategori
Forskningsprogram
Medicin/Teknik
Identifikatorer
URN: urn:nbn:se:gih:diva-8182DOI: 10.1371/journal.pone.0301412ISI: 001198071500071PubMedID: 38578722OAI: oai:DiVA.org:gih-8182DiVA, id: diva2:1851146
Tilgjengelig fra: 2024-04-12 Laget: 2024-04-12 Sist oppdatert: 2024-05-21

Open Access i DiVA

fulltext(859 kB)25 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 859 kBChecksum SHA-512
89b38b7383ac9e3f0b6ba2d73823d3497ab16e731b7d47f36bf1385a3e8f3d562d99f37f6c77db6f6ae7a4855d29fcf2954b761d738306a457fd6a9d08a21ce2
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Person

Ekblom, ÖrjanEkblom Bak, Elin

Søk i DiVA

Av forfatter/redaktør
Ekblom, ÖrjanEkblom Bak, Elin
Av organisasjonen
I samme tidsskrift
PLOS ONE

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 25 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 230 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf