Gymnastik- och idrottshögskolan, GIH

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Association of Sarcopenia and Its Defining Components with the Degree of Cognitive Impairment in a Memory Clinic Population.
Swedish School of Sport and Health Sciences, GIH, Department of Physical Activity and Health. Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden. (Master student)
Swedish School of Sport and Health Sciences, GIH, Department of Physical Activity and Health. Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.. (Fysisk aktivitet och hjärnhälsa)ORCID iD: 0000-0001-7209-741x
Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.; Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden..
Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.; Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden..
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2023 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 96, no 2, p. 777-788Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Sarcopenia and cognitive impairment are two leading causes of disabilities.

OBJECTIVE: The objective was to examine the prevalence of sarcopenia and investigate the association between sarcopenia diagnostic components (muscle strength, muscle mass, and physical performance) and cognitive impairment in memory clinic patients.

METHODS: 368 patients were included (age 59.0±7.25 years, women: 58.7%), displaying three clinical phenotypes of cognitive impairments, i.e., subjective cognitive impairment (SCI, 57%), mild cognitive impairment (MCI, 26%), and Alzheimer's disease (AD, 17%). Sarcopenia was defined according to diagnostic algorithm recommended by the European Working Group on Sarcopenia in Older People. Components of sarcopenia were grip strength, bioelectrical impedance analysis, and gait speed. They were further aggregated into a score (0-3 points) by counting the numbers of limited components. Multi-nominal logistic regression was applied.

RESULTS: Probable sarcopenia (i.e., reduced grip strength) was observed in 9.6% of the patients, and 3.5% were diagnosed with sarcopenia. Patients with faster gait speed showed less likelihood of MCI (odds ratio [OR]: 0.24, 95% confidence interval [CI]: 0.06-0.90) and AD (OR: 0.12, 95% CI: 0.03-0.60). One or more limited sarcopenia components was associated with worse cognitive function. After adjusting for potential confounders, the association remained significant only for AD (OR 4.29, 95% CI 1.45-11.92).

CONCLUSION: The results indicate a connection between the sarcopenia components and cognitive impairments. Limitations in the sarcopenia measures, especially slow walking speed, were related to poorer cognitive outcomes. More investigationsare required to further verify the causal relationship between sarcopenia and cognitive outcomes.

Place, publisher, year, edition, pages
IOS Press, 2023. Vol. 96, no 2, p. 777-788
Keywords [en]
Alzheimer’s disease, body composition, cognitive function, gait speed, hand grip strength, outpatients, sarcopenia, E-PABS, EPABS, hjärnhälsa, brain health
National Category
Geriatrics Neurology
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-7949DOI: 10.3233/JAD-221186ISI: 001099536400028PubMedID: 37899056OAI: oai:DiVA.org:gih-7949DiVA, id: diva2:1813184
Part of project
E-PABS - a centre of Excellence in Physical Activity, healthy Brain functions and Sustainability, Knowledge FoundationWhat can motor function tell us about cognitive aging and dementia? A multidisciplinary approach towards precision medicine, Swedish Research CouncilExploring neighbourhood effects on aging: An opportunity for enhancing brain health across the lifespan, Knowledge Foundation
Funder
Swedish Research Council, 2022-01404Knowledge Foundation, 2018-0151, 2021-0002, 2022-0202The Karolinska Institutet's Research Foundation, 2022-02248Available from: 2023-11-20 Created: 2023-11-20 Last updated: 2024-03-22

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Wang, Rui

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