Gymnastik- och idrottshögskolan, GIH

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The role of acute changes in mBDNF, cortisol and pro-BDNF in predicting cognitive performance in old age.
Swedish School of Sport and Health Sciences, GIH, Department of Physical Activity and Health. Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden..ORCID iD: 0000-0002-6746-0920
Swedish School of Sport and Health Sciences, GIH, Department of Physical Activity and Health. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. (Fysisk aktivitet och hjärnhälsa)ORCID iD: 0000-0002-7879-9188
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics.ORCID iD: 0000-0003-3747-0148
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Psychology, University of Gothenburg, Gothenburg, Sweden..
2023 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 13, no 1, article id 9418Article in journal (Refereed) Published
Abstract [en]

The interplay between biomarkers of relevance to neuroplasticity and its association with learning and cognitive ability in old age remains poorly understood. The present study investigated acute changes in plasma concentrations of mature brain-derived neurotrophic factor (mBDNF), its precursor protein (pro-BDNF), and cortisol, in response to acute physical exercise and cognitive training interventions, their covariation and role in predicting cognitive performance. Confirmatory results provided no support for mBDNF, pro-BDNF and cortisol co-varying over time, as the acute interventions unfolded, but did confirm a positive association between mBDNF and pro-BDNF at rest. The confirmatory results did not support the hypothesis that mBDNF change following physical exercise were counteracted by temporally coupled changes in cortisol or pro-BDNF, or by cortisol at rest, in its previously demonstrated faciliatory effect on cognitive training outcome. Exploratory results instead provided indications of a general and trait-like cognitive benefit of exhibiting greater mBDNF responsiveness to acute interventions when coupled with lesser cortisol responsiveness, greater pro-BDNF responsiveness, and lower cortisol at rest. As such, the results call for future work to test whether certain biomarker profiles are associated with preserved cognition in old age.

Place, publisher, year, edition, pages
Nature Publishing Group, 2023. Vol. 13, no 1, article id 9418
Keywords [sv]
E-PABS, EPABS, hjärnhälsa, brain health
National Category
Neurosciences
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-7671DOI: 10.1038/s41598-023-35847-5ISI: 001006690200060PubMedID: 37296176OAI: oai:DiVA.org:gih-7671DiVA, id: diva2:1775026
Part of project
E-PABS - a centre of Excellence in Physical Activity, healthy Brain functions and Sustainability, Knowledge FoundationAvailable from: 2023-06-26 Created: 2023-06-26 Last updated: 2024-03-22

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Nilsson, JonnaEkblom, MariaMoberg, Marcus

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