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Lack of sex differences in the IGF-IGFBP response to ultra endurance exercise.
Institutionen för Kvinnors och Barns Hälsa (KBH), Karolinska Institutet. (Enheten för barnendokrinologi, Astrid Lindgrens Barnsjukhus)
Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, Björn Ekbloms forskningsgrupp. (Adventure Racing Research)
Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, Björn Ekbloms forskningsgrupp. (Adventure Racing Research GIH samt Institutionen för fysiologi och farmakologi (FyFa), Karolinska Institutet)ORCID-id: 0000-0002-0642-4838
Institutionen för Kvinnors och Barns Hälsa (KBH), Karolinska Institutet. (Pediatric Endocrinology Unit, Astrid LindgrenEnheten för barnendokrinologi, Astrid Lindgrens Barnsjukhus Children's Hospital)
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2008 (engelsk)Inngår i: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 18, nr 6, s. 706-714Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The insulin-like growth factor (IGF)-IGF binding proteins (BP) and the pituitary-gonadal axes were investigated during ultra endurance exercise in 16 endurance-trained athletes (seven women). Median duration of the race was 6.3 days. Although food and drink were ad libitum, energy balance was negative. Blood samples were drawn before (PRE), at the end of (END) and 24 h after (POST24h) the race. Serum concentrations of total IGF-I (t-IGF-I) and free IGF-I (f-IGF-I) decreased by 33 (SD 38)% and 54 (19)%, respectively. The decrease in t-IGF-I appeared to be associated to the total energy deficit during the race. At END, the IGFBP-3 fragmentation and IGFBP-1 were increased but these changes did not predict changes in f-IGF-I. An increase in POST24h IGFBP-2 levels in women was the only sex difference. Testosterone was decreased by 67 (12)% in the men and estradiol became undetectable in the women without any detectable increase in LH and/or FSH. In conclusion ultra endurance exercise results in similar IGF-IGFBP responses in men and women reflecting a catabolic state. IGFBP-2 was the only exception, with increased levels in women after exercise. A concomitant decrease in gonadal hormones was not related to endocrine changes in the IGF-IGFBP axis but may be related to local changes in IGF-I expression.

sted, utgiver, år, opplag, sider
2008. Vol. 18, nr 6, s. 706-714
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URN: urn:nbn:se:gih:diva-839DOI: 10.1111/j.1600-0838.2007.00758.xPubMedID: 18248538OAI: oai:DiVA.org:gih-839DiVA, id: diva2:174855
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Physiology of Adventure RacingTilgjengelig fra: 2009-02-25 Laget: 2009-02-25 Sist oppdatert: 2018-01-13bibliografisk kontrollert

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