Gymnastik- och idrottshögskolan, GIH

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Limited effect of over-the-counter doses of ibuprofen on mechanisms regulating muscle hypertrophy during resistance training in young adults.
Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, Stockholm, Sweden ; Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden..
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics.ORCID iD: 0000-0003-3747-0148
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics.ORCID iD: 0000-0003-1942-2919
Movement Analysis Laboratory for Sport and Health (MALab), Faculty of Sport, Catholic University of Murcia, Spain..
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2023 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 134, no 3, p. 753-765Article in journal (Refereed) Published
Abstract [en]

We have previously shown that maximal over-the-counter doses of ibuprofen, compared with low doses of acetylsalicylic acid, reduce muscle hypertrophy in young individuals after 8 weeks of resistance training. Because the mechanism behind this effect has not been fully elucidated, we here investigated skeletal muscle molecular responses and myofiber adaptations in response to acute and chronic resistance training with concomitant drug intake. Thirty-one young (aged 18-35 years) healthy men (n=17) and women (n=14) were randomized to receive either ibuprofen (IBU;1200mg daily; n=15) or acetylsalicylic acid (ASA; 75mg daily; n=16) while undergoing 8 weeks of knee extension training. Muscle biopsies from the vastus lateralis were obtained before, at week 4 after an acute exercise session, and after 8 weeks of resistance training and analyzed for mRNA markers and mTOR signaling, as well as quantification of total RNA content (marker of ribosome biogenesis) and immunohistochemical analyzes of muscle fiber size, satellite cell content, myonuclear accretion, and capillarization. There were only two treatment ´ time interaction in selected molecular markers after acute exercise (atrogin-1 and MuRF1 mRNA), but several exercise effects. Muscle fiber size, satellite cell and myonuclear accretion, and capillarization were not affected by chronic training or drug intake. RNA content increased comparably (~14%) in both groups. Collectively, these data suggest that established acute and chronic hypertrophy regulators (including mTOR signaling, ribosome biogenesis, satellite cell content, myonuclear accretion, and angiogenesis) were not differentially affected between groups and therefore do not explain the deleterious effects of ibuprofen on muscle hypertrophy in young adults.

Place, publisher, year, edition, pages
American Physiological Society , 2023. Vol. 134, no 3, p. 753-765
Keywords [en]
Non-steroidal anti-inflammatory drugs, Resistance exercise, Ribosome biogenesis, Satellite cells, Skeletal muscle
National Category
Sport and Fitness Sciences
Research subject
Medicine/Technology
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URN: urn:nbn:se:gih:diva-7522DOI: 10.1152/japplphysiol.00698.2022ISI: 000972694300002PubMedID: 36794689OAI: oai:DiVA.org:gih-7522DiVA, id: diva2:1741231
Available from: 2023-03-03 Created: 2023-03-03 Last updated: 2023-06-12

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Moberg, MarcusApro, William

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