Gymnastik- och idrottshögskolan, GIH

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Insulin resistance after a 3-day fast is associated with an increased capacity of skeletal muscle to oxidize lipids.
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics. (Åstrand Laboratory)ORCID iD: 0000-0002-4853-6627
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics. (Åstrand Laboratory)ORCID iD: 0000-0002-3500-2896
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.. (Åstrand Laboratory)ORCID iD: 0000-0003-3747-0148
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics. (Åstrand Laboratory)ORCID iD: 0000-0002-0081-4691
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2023 (English)In: American Journal of Physiology. Endocrinology and Metabolism, ISSN 0193-1849, E-ISSN 1522-1555, Vol. 324, no 5, p. E390-E401Article in journal (Refereed) Published
Abstract [en]

There is a debate on whether lipid-mediated insulin resistance derives from an increased or decreased capacity of muscle to oxidize fats. Here we examine the involvement of muscle fiber composition in the metabolic responses to a 3-day fast (starvation, which results in increases in plasma lipids and insulin resistance) in two groups of healthy young subjects: 1, area occupied by type I fibers = 61.0 ± 11.8%; 2, type I area = 36.0 ± 4.9% (P<0.001). Muscle biopsies and intravenous glucose tolerance tests were performed after an overnight fast and after starvation. Biopsies were analyzed for muscle fiber composition and mitochondrial respiration. Indices of glucose tolerance and insulin sensitivity were determined. Glucose tolerance was similar in both groups after an overnight fast and deteriorated to a similar degree in both groups after starvation. In contrast, whole-body insulin sensitivity decreased markedly after starvation in group 1 (P<0.01), whereas the decrease in group 2 was substantially smaller (P=0.06). Non-esterified fatty acids and β-hydroxybutyrate levels in plasma after an overnight fast were similar between groups and increased markedly and comparably in both groups after starvation, demonstrating similar degrees of lipid load. The capacity of permeabilized muscle fibers to oxidize lipids was significantly higher in group 1 vs. 2, whereas there was no significant difference in pyruvate oxidation between groups. The data demonstrate that loss of whole-body insulin sensitivity after short-term starvation is a function of muscle fiber composition and is associated with an elevated rather than a diminished capacity of muscle to oxidize lipids.

Place, publisher, year, edition, pages
American Physiological Society, 2023. Vol. 324, no 5, p. E390-E401
Keywords [en]
glucose tolerance, insulin resistance, mitochondrial respiration, muscle fiber composition, starvation
National Category
Physiology Endocrinology and Diabetes
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Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-7521DOI: 10.1152/ajpendo.00317.2022ISI: 000974241700002PubMedID: 36791323OAI: oai:DiVA.org:gih-7521DiVA, id: diva2:1741224
Available from: 2023-03-03 Created: 2023-03-03 Last updated: 2024-01-11

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Blackwood, Sarah JHorwath, OscarMoberg, MarcusPontén, MarjanApro, WilliamEkblom, MariaLarsen, Filip JKatz, Abram

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Blackwood, Sarah JHorwath, OscarMoberg, MarcusPontén, MarjanApro, WilliamEkblom, MariaLarsen, Filip JKatz, Abram
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Department of Physiology, Nutrition and BiomechanicsDepartment of Physical Activity and Health
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American Journal of Physiology. Endocrinology and Metabolism
PhysiologyEndocrinology and Diabetes

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