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Can dementia risk be reduced by following the American Heart Association's Life's Simple 7?: A systematic review and dose-response meta-analysis.
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden..
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden..
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden..
Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden..
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2023 (English)In: Ageing Research Reviews, ISSN 1568-1637, E-ISSN 1872-9649, Vol. 83, article id 101788Article in journal (Refereed) Published
Abstract [en]

This study aimed to quantify the relationships between the American Heart Association (AHA) Cardiovascular Health (CVH) metrics, namely AHA Life's Simple 7, and cognitive outcomes. We searched PubMed and Embase (January 1, 2010-August 24, 2022) and finally included 14 longitudinal studies (311654 participants with 8006 incident dementia cases). Random-effects meta-analysis and one-stage linear mixed-effects models were performed. Increased CVH score seemed to associate with decreased risk of incident dementia in a linear manner, but this relationship varied by the measurement age of CVH metrics. That is, midlife CVH tended to have a linear association with late-life dementia risk, whereas a J-shaped association was observed between the late-life CVH score and dementia. In addition, late-life dementia risk was reduced significantly if individuals maintained an ideal level of AHA's CVH guidelines of physical activity, fasting plasma glucose, total cholesterol, and smoking. However, our meta-analysis did not show a significant association between CVH score and global cognitive decline rate. Following AHA's CVH guidelines and maintaining CVH at an optimal level would substantially reduce the late-life dementia risk. More research is required to explore the link between a favorable CVH score and cognitive trajectories among cognitively asymptomatic older populations.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 83, article id 101788
Keywords [en]
Cardiovascular health, Dementia, Global cognitive function, Life’s Simple 7, Meta-analysis, E-PABS, EPABS, brain health, hjärnhälsa
National Category
Geriatrics
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-7425DOI: 10.1016/j.arr.2022.101788ISI: 000974976400001PubMedID: 36371016OAI: oai:DiVA.org:gih-7425DiVA, id: diva2:1715743
Part of project
E-PABS - a centre of Excellence in Physical Activity, healthy Brain functions and Sustainability, Knowledge FoundationWhat can motor function tell us about cognitive aging and dementia? A multidisciplinary approach towards precision medicine, Swedish Research CouncilAvailable from: 2022-12-02 Created: 2022-12-02 Last updated: 2024-03-26

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Wang, Rui

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