Gymnastik- och idrottshögskolan, GIH

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Extreme Variations in Muscle Fiber Composition Enable Detection of Insulin Resistance and Excessive Insulin Secretion.
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics. (Åstrandlaboratoriet)ORCID iD: 0000-0002-4853-6627
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics. (Åstrandlaboratoriet)ORCID iD: 0000-0002-3500-2896
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. (Åstrandlaboratoriet)ORCID iD: 0000-0003-3747-0148
Swedish School of Sport and Health Sciences, GIH, Department of Physiology, Nutrition and Biomechanics. (Åstrandlaboratoriet)ORCID iD: 0000-0002-0081-4691
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2022 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 107, no 7, p. e2729-e2737, article id dgac221Article in journal (Refereed) Published
Abstract [en]

CONTEXT: Muscle fiber composition is associated with peripheral insulin action.

OBJECTIVE: We investigated whether extreme differences in muscle fiber composition are associated with alterations in peripheral insulin action and secretion in young, healthy subjects who exhibit normal fasting glycemia and insulinemia.

METHODS: Relaxation time following a tetanic contraction was used to identify subjects with a high or low expression of type I muscle fibers: group I (n=11), area occupied by type I muscle fibers = 61.0 ± 11.8%; group II (n=8), type I area = 36.0 ± 4.9% (P<0.001). Biopsies were obtained from the vastus lateralis muscle and analyzed for mitochondrial respiration on permeabilized fibers, muscle fiber composition and capillary density. An intravenous glucose tolerance test was performed and indices of glucose tolerance, insulin sensitivity and secretion were determined.

RESULTS: Glucose tolerance was similar between groups, whereas whole-body insulin sensitivity was decreased by ~50% in group II vs group I (P=0.019). First phase insulin release (area under the insulin curve during 10 min after glucose infusion) was increased by almost 4-fold in group II vs I (P=0.01). Whole-body insulin sensitivity was correlated with % area occupied by type I fibers (r=0.54; P=0.018) and capillary density in muscle (r=0.61; P=0.005), but not with mitochondrial respiration. Insulin release was strongly related to % area occupied by type II fibers (r=0.93; P<0.001).

CONCLUSIONS: Assessment of muscle contractile function in young healthy subjects may prove useful in identifying individuals with insulin resistance and enhanced glucose stimulated insulin secretion prior to onset of clinical manifestations.

Place, publisher, year, edition, pages
Oxford University Press, 2022. Vol. 107, no 7, p. e2729-e2737, article id dgac221
Keywords [en]
insulin, insulin resistance, insulin secretion, intravenous glucose tolerance test, mitochondrial respiration, muscle fiber type
National Category
Endocrinology and Diabetes
Research subject
Medicine/Technology; Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-7053DOI: 10.1210/clinem/dgac221ISI: 000789019300001PubMedID: 35405014OAI: oai:DiVA.org:gih-7053DiVA, id: diva2:1658923
Available from: 2022-05-18 Created: 2022-05-18 Last updated: 2022-12-06

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Blackwood, Sarah JHorwath, OscarMoberg, MarcusPontén, MarjanApro, WilliamEkblom, MariaLarsen, Filip JKatz, Abram

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Blackwood, Sarah JHorwath, OscarMoberg, MarcusPontén, MarjanApro, WilliamEkblom, MariaLarsen, Filip JKatz, Abram
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Department of Physiology, Nutrition and BiomechanicsDepartment of Physical Activity and Health
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Journal of Clinical Endocrinology and Metabolism
Endocrinology and Diabetes

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