Gymnastik- och idrottshögskolan, GIH

Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study.
Swedish School of Sport and Health Sciences, GIH, Department of Physical Activity and Health. University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Karolinska Institutet and Stockholm University, Stockholm, Sweden. (Fysisk aktivitet och hjärnhälsa)ORCID iD: 0000-0001-7209-741x
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Middleton Memorial Veterans Hospital, Madison, WI, USA..
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Show others and affiliations
2021 (English)In: Journal of Cerebral Blood Flow and Metabolism, ISSN 0271-678X, E-ISSN 1559-7016, Vol. 41, no 11, p. 3016-3027Article in journal (Refereed) Published
Abstract [en]

Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer's disease, but the natural trajectory of cerebral perfusion in cognitively healthy adults has not been well-studied. This longitudinal study is consisted of 950 participants (40-89 years), who were cognitively unimpaired at their first visit. We investigated the age-related changes in cerebral perfusion, and their associations with APOE-genotype, biological sex, and cardiometabolic measurements. During the follow-up period (range 0.13-8.24 years), increasing age was significantly associated with decreasing cerebral perfusion, in total gray-matter (β=-1.43), hippocampus (-1.25), superior frontal gyrus (-1.70), middle frontal gyrus (-1.99), posterior cingulate (-2.46), and precuneus (-2.14), with all P-values < 0.01. Compared with male-ɛ4 carriers, female-ɛ4 carriers showed a faster decline in global and regional cerebral perfusion with increasing age, whereas the age-related decline in cerebral perfusion was similar between male- and female-ɛ4 non-carriers. Worse cardiometabolic profile (i.e., increased blood pressure, body mass index, total cholesterol, and blood glucose) was associated with lower cerebral perfusion at all the visits. When time-varying cardiometabolic measurements were adjusted in the model, the synergistic effect of sex and APOE-ɛ4 on age-related cerebral perfusion-trajectories became largely attenuated. Our findings demonstrate that APOE-genotype and sex interactively impact cerebral perfusion-trajectories in mid- to late-life. This effect may be partially explained by cardiometabolic alterations.

Place, publisher, year, edition, pages
Sage Publications, 2021. Vol. 41, no 11, p. 3016-3027
Keywords [en]
APOE gene, Alzheimer’s disease, Cerebral perfusion, cardiometabolic measurements, chromosomal sex
National Category
Neurosciences
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-6750DOI: 10.1177/0271678X211021313ISI: 000680615100001PubMedID: 34102919OAI: oai:DiVA.org:gih-6750DiVA, id: diva2:1576860
Available from: 2021-07-01 Created: 2021-07-01 Last updated: 2021-11-02

Open Access in DiVA

fulltext(863 kB)136 downloads
File information
File name FULLTEXT01.pdfFile size 863 kBChecksum SHA-512
098fd5857b99c79a54b43b896d3ff4d22b9cd242e2df926a62bfa99775c346bc66620167367f7fca9cd1a409034b1bfefc0682a6f15c88c7d1f1ccdc74f49d9a
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records

Wang, Rui

Search in DiVA

By author/editor
Wang, Rui
By organisation
Department of Physical Activity and Health
In the same journal
Journal of Cerebral Blood Flow and Metabolism
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 136 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 220 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf