Gymnastik- och idrottshögskolan, GIH

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Cerebral Small Vessel Disease Associated With Atrial Fibrillation Among Older Adults: A Population-Based Study.
Karolinska Institutet, Stockholm University, Sweden.
Swedish School of Sport and Health Sciences, GIH, Department of Physical Activity and Health. Karolinska Institutet, Stockholm University, Sweden. (Fysisk aktivitet och hjärnhälsa)ORCID iD: 0000-0001-7209-741x
Karolinska Institutet, Stockholm, Sweden..
Karolinska Institutet, Stockholm, Sweden; Stockholm Gerontology Research Center, Sweden.
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2021 (English)In: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 52, no 8, p. 2685-2689Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND PURPOSE: Cerebral small vessel disease, as a potential mechanism underlying the association between atrial fibrillation (AF) and dementia, remains poorly investigated. In this cohort study, we sought to examine the association between AF and cerebral small vessel disease markers among older adults.

METHODS: Data on 336 participants (age ≥60 years, mean 70.2 years; 60.2% women) free of dementia, disability, and cerebral infarcts were derived from the population-based Swedish National Study on Aging and Care in Kungsholmen. Structural brain magnetic resonance imaging examinations were performed at baseline (2001-2004) and follow-ups (2004-2007 and 2007-2010). Magnetic resonance imaging markers of cerebral small vessel disease included perivascular spaces, lacunes, and volumes of white matter hyperintensities, lateral ventricles, and total brain tissue. AF was assessed at baseline and follow-ups through clinical examinations, electrocardiogram, and medical records. Data were analyzed using linear mixed-effects models.

RESULTS: At baseline, 18 persons (5.4%) were identified to have prevalent AF and 17 (5.6%) developed incident AF over the 6-year follow-up. After multivariable adjustment, AF was significantly associated with a faster annual increase in white matter hyperintensities volume (β coefficient=0.45 [95% CI, 0.04-0.86]) and lateral ventricular volume (0.58 [0.13-1.02]). There was no significant association of AF with annual changes in perivascular spaces number (β coefficient=0.53 [95% CI, -0.27 to 1.34]) or lacune number (-0.01 [-0.07 to 0.05]).

CONCLUSIONS: Independent of cerebral infarcts, AF is associated with accelerated progression of white matter lesions and ventricular enlargement among older adults.

Place, publisher, year, edition, pages
American Heart Association , 2021. Vol. 52, no 8, p. 2685-2689
Keywords [en]
atrial fibrillation, cerebral infarction, cerebral small vessel diseases, dementia, magnetic resonance imaging
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Neurology
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-6738DOI: 10.1161/STROKEAHA.120.031573ISI: 000677821800041PubMedID: 34134506OAI: oai:DiVA.org:gih-6738DiVA, id: diva2:1573954
Available from: 2021-06-28 Created: 2021-06-28 Last updated: 2021-12-17Bibliographically approved

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Wang, Rui

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