Gymnastik- och idrottshögskolan, GIH

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Shared risk and protective factors between Alzheimer's disease and ischemic stroke: A population-based longitudinal study.
Swedish School of Sport and Health Sciences, GIH, Department of Physical Activity and Health. Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden ; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA..ORCID iD: 0000-0001-7209-741x
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden..
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden..
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden..
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2021 (English)In: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 17, no 2, p. 191-204Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Stroke, especially ischemic stroke's (IS) link with Alzheimer's disease (AD) remains unclear.

METHODS: This prospective cohort study included 2459 AD- and cerebrovascular disease-free older adults at baseline (mean age 71.9 ± 10.3 years, Stockholm, Sweden). Using Cox regressions, shared risk factors (SRFs) and shared protective factors (SPFs) between AD and IS were recognized when their hazard ratios in both AD and IS models were significant and in the same direction.

RESULTS: During the follow-up period of up to 15 years, 132 AD and 260 IS mutually exclusive cases were identified. SRFs were low education, sedentary lifestyle, and heart diseases. High levels of psychological well-being, actively engaging in leisure activities, and a rich social network were SPFs. Having ≥1 SPF reduced 47% of AD and 28% of IS risk among people with a low risk profile (<2 SRFs), and 38% of AD and 31% of IS risk with a high risk profile (≥2 SRFs). In total, 57.8% of AD/IS cases could be prevented if individuals have ≥1 SPF and no SRF.

DISCUSSION: AD and IS share risk/protective profiles, and SPFs seem to counteract the adverse effects of SRFs on both AD and IS.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021. Vol. 17, no 2, p. 191-204
Keywords [en]
Alzheimer's diseases, Cohort study, Ischemic stroke, Leisure activity, Psychological well-being, Social network, Vascular risk factors
National Category
Cardiac and Cardiovascular Systems
Research subject
Medicine/Technology
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URN: urn:nbn:se:gih:diva-6539DOI: 10.1002/alz.12203ISI: 000623284000004PubMedID: 33527694OAI: oai:DiVA.org:gih-6539DiVA, id: diva2:1527235
Available from: 2021-02-10 Created: 2021-02-10 Last updated: 2023-03-28

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Wang, Rui

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