Gymnastik- och idrottshögskolan, GIH

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Association of diabetes with stroke and post-stroke dementia: A population-based cohort study
Karolinska Institutet & Stockholm University, Stockholm, Sweden..ORCID iD: 0000-0002-1496-1799
Karolinska Institutet & Stockholm University, Stockholm, Sweden..
Karolinska Institutet & Stockholm University, Stockholm, Sweden..
Karolinska Institutet, Stockholm, Sweden..
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2020 (English)In: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 16, no 7, p. 1003-1012Article in journal (Refereed) Published
Abstract [en]

Introduction: The impact of prediabetes and diabetes on stroke and the development of dementia after a stroke remain unclear. Methods: A total of 2655 dementia-free participants (including a stroke-free cohort and a prevalent stroke cohort) were followed-up for 12 years. Dementia and post-stroke dementia were determined by clinical examinations and national registry data. Diabetes was ascertained via medical examination, medication use, medical records, or glycated hemoglobin (HbA1c) >= 6.5%. Prediabetes was defined as H bA1c >= 5.7% in diabetes-free participants. Results: In the stroke-free cohort, 236 participants developed ischemic stroke, and 47 developed post-stroke dementia. Diabetes was associated with ischemic stroke (hazard ratio [HR] 1.76, 95% confidence interval [CI] 1.16 to 2.67) and post-stroke dementia (HR 2.56, 95% CI 1.04 to 6.25). In the prevalent stroke cohort, diabetes was also related to dementia risk. Prediabetes was not significantly related to stroke or post-stroke dementia. Discussion: Diabetes, but not prediabetes, is associated with an increased risk of ischemic stroke and post-stroke dementia.

Place, publisher, year, edition, pages
John Wiley & Sons, 2020. Vol. 16, no 7, p. 1003-1012
Keywords [en]
dementia, ischemic stroke, population-based cohort study, post-stroke dementia, prediabetes, type 2 diabetes
National Category
Geriatrics
Research subject
Medicine/Technology
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URN: urn:nbn:se:gih:diva-6344DOI: 10.1002/alz.12101ISI: 000577871300006PubMedID: 32489021OAI: oai:DiVA.org:gih-6344DiVA, id: diva2:1485357
Available from: 2020-11-02 Created: 2020-11-02 Last updated: 2023-03-28

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Wang, Rui

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Department of Physical Activity and Health
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