Gymnastik- och idrottshögskolan, GIH

Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Life-course blood pressure trajectories and cardiovascular diseases: A population-based cohort study in China.
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Swedish School of Sport and Health Sciences, GIH, Department of Physical Activity and Health. Karolinska Institutet and Stockholm University, Stockholm, Sweden; University of Wisconsin School of Medicine and Public Health, Wisconsin, United States of America.ORCID iD: 0000-0001-7209-741x
Karolinska Institutet, Stockholm, Sweden.
2020 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 15, no 10, article id e0240804Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The patterns of blood pressure trajectory (i.e., change over time) over life-course remain to be explored. In this study, we aim to determine the trajectories of systolic blood pressure (SBP) from adulthood to late life and to assess its impact on the risk of cardiovascular diseases (CVDs).

METHODS: Based on the China Health and Nutrition Survey, a total of 3566 participants aged 20-50 years at baseline (1989) with at least three SBP measurements during 1989-2011 were included. SBP was measured through physical examination, and socio-demographic factors, lifestyles, medications, and CVDs were based on self-reported questionnaire. Latent class growth modeling was performed to examine SBP trajectory. Odds ratio (OR) and 95% confidence interval (CI) from logistic regression was used to determine the association between SBP trajectory and CVDs.

RESULTS: Five trajectory groups of SBP were identified: Class 1: rapid increase (n = 113, 3.2%); Class 2: slight increase (n = 1958, 54.9%); Class 3: stable (n = 614, 17.2%); Class 4: increase (n = 800, 22.4%); Class 5: fluctuant (n = 81, 2.3%). After adjustment of demographic factors, baseline SBP, and lifestyles, compared with the "slight increase" group, the OR (95% CI) of CVDs was 0.65 (0.32, 1.28) for "stable" group, 2.24 (1.40, 3.58) for "increase" group, 3.95 (1.81, 8.62) for "rapid increase" group, and 4.32 (1.76, 10.57) for "fluctuant" group. After stratified by use of antihypertensive drugs, the association was only significant for "rapid increase" group among those using antihypertensive drugs with OR (95% CI) of 2.81 (1.01, 7.77).

CONCLUSIONS: Having a rapidly increasing SBP over life-course is associated with a higher risk of CVDs. This implies the importance of monitoring lifetime change of blood pressure for the prevention of CVDs.

Place, publisher, year, edition, pages
Public Library of Science (PLoS) , 2020. Vol. 15, no 10, article id e0240804
National Category
Cardiac and Cardiovascular Systems
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-6343DOI: 10.1371/journal.pone.0240804ISI: 000585943400039PubMedID: 33085698OAI: oai:DiVA.org:gih-6343DiVA, id: diva2:1485339
Available from: 2020-11-02 Created: 2020-11-02 Last updated: 2021-06-14

Open Access in DiVA

fulltext(572 kB)58 downloads
File information
File name FULLTEXT02.pdfFile size 572 kBChecksum SHA-512
bef72b03c9221c1bf2d0e9edd6ef56c0e29f7a978aeb78d126092672c302bc384d5c03f932f2acb0431d4e3d525dd33195a173a40ffba1ef958f802ab3e85a62
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records

Wang, Rui

Search in DiVA

By author/editor
Wang, Rui
By organisation
Department of Physical Activity and Health
In the same journal
PLOS ONE
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar
Total: 62 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 238 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf