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Sex- and age-specific associations between cardiorespiratory fitness, CVD morbidity and all-cause mortality in 266.109 adults.
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology.ORCID iD: 0000-0002-3901-7833
Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, Björn Ekblom's research group.ORCID iD: 0000-0002-4030-5437
Karolinska institutet.
University of Gothenburg.
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2019 (English)In: Preventive Medicine, ISSN 0091-7435, E-ISSN 1096-0260, Vol. 127, article id 105799Article in journal (Refereed) Published
Abstract [en]

The aim was to investigate sex- and age-specific associations between cardiorespiratory fitness, all-cause and cause-specific mortality, and cardiovascular disease (CVD) morbidity. 266.109 participants (47% women, 18-74 years) free from CVD, participating in occupational health service screenings in 1995-2015 were included. CRF was assessed as estimated maximal oxygen consumption (estVO2max) using a submaximal cycle test. Incident cases of first-time CVD event and death from any cause were ascertained through national registers. There were 4244 CVD events and 2750 cases of all-cause mortality during mean 7.6 years follow-up. Male gender, higher age and lower estVO2max were associated with higher all-cause mortality and CVD morbidity incidence rates. Risk reductions with increasing estVO2max were present in all age-groups of men and women. No obvious levelling off in risk was identified in the total cohort. However, women and older age-groups showed no further reduction in higher aggregated estVO2max levels. CVD specific mortality was more associated with estVO2max compared to tumor specific mortality. The risk for all-cause mortality and CVD morbidity decreased by 2.3% and 2.6% per increase in 1 ml·min-1·kg-1 with no significant sex-differences but more pronounced in the three lower estVO2max categories for all-cause mortality (9.1%, 3.8% and 3.3%, respectively). High compared to lower levels of estVO2max was not related to a significantly elevated mortality or morbidity. In this large cohort study, CVD morbidity and all-cause mortality were inversely related to estVO2max in both men and women of all age-groups. Increasing cardiorespiratory fitness is a clear public health priority.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 127, article id 105799
Keywords [en]
Aerobic capacity, Cancer, Cardiovascular disease, Population, Risk, VO(2)max
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Medicine/Technology
Identifiers
URN: urn:nbn:se:gih:diva-5834DOI: 10.1016/j.ypmed.2019.105799ISI: 000485788400010PubMedID: 31454664OAI: oai:DiVA.org:gih-5834DiVA, id: diva2:1351677
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HPI-gruppenAvailable from: 2019-09-16 Created: 2019-09-16 Last updated: 2019-10-11

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Ekblom Bak, ElinEkblom, BjörnBlom, VictoriaKallings, LenaHemmingsson, ErikEkblom, Örjan

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Ekblom Bak, ElinEkblom, BjörnBlom, VictoriaKallings, LenaHemmingsson, ErikEkblom, Örjan
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Åstrand Laboratory of Work PhysiologyBjörn Ekblom's research groupSport Psychology research groupDepartment of Sport and Health Sciences
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