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Acute exercise during starvation improves insulin sensitivity and increases mitochondrial FA oxidation
Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, Forskningsgruppen Mitokondriell funktion och metabolisk kontroll.
Institutionen för Fysiologi och Farmakologi, Karolinska Institutet.
Gymnastik- och idrottshögskolan, GIH.ORCID-id: 0000-0001-9040-2158
Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, Forskningsgruppen Mitokondriell funktion och metabolisk kontroll.
2012 (engelsk)Konferansepaper, Publicerat paper (Annet vitenskapelig)
Abstract [en]

Aim: To investigate if exercise can reverse starvation-induced insulin resistance and to elucidate the mechanism. Methods: Nine subjects underwent 87 h of starvation with (EX) or without (NE) one exercise session at the end. Before and after starvation (3 h post-exercise) subjects underwent an intravenous glucose tolerance test and muscle biopsy. Results: Insulin sensitivity decreased after starvation (NE) but increased after exercise (EX). Glycogen stores were reduced and plasma FA and β-Hydroxybutyrate increased in both conditions. Mitochondrial respiration with FA substrate increased in EX but was unchanged in NE. RCR and mitochondrial ROS production decreased in both conditions. Phosphorylation of Acetyl-CoA carboxylase (ACC) and Akt substrate of 160 kDA (AS160) proteins increased in EX. Conclusion: Exercise improves starvation induced insulin resistance, probably by increased mitochondrial FA oxidation, reduced glycogen stores and alterations in signaling proteins involved in glucose uptake and FA metabolism.

sted, utgiver, år, opplag, sider
2012.
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URN: urn:nbn:se:gih:diva-2600OAI: oai:DiVA.org:gih-2600DiVA, id: diva2:581593
Konferanse
15th International Biochemistry of Exercise Congress (IBEC) in Stockholm, Sweden, June 17-21, 2012
Tilgjengelig fra: 2013-01-02 Laget: 2013-01-02 Sist oppdatert: 2016-08-10bibliografisk kontrollert

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