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Microdialysis of rat skeletal muscle and adipose tissue: dynamics of the interstitial glucose pool.
Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap.
Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap.ORCID-id: 0000-0001-8161-5610
Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap.
Vise andre og tillknytning
1994 (engelsk)Inngår i: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 151, nr 2, s. 249-60Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Microdialysis was evaluated as a method for studying glucose metabolism in skeletal muscle. Dialysis probes (0.5 x 10 mm) were perfused at 0.5 or 1.0 microliter min-1. Based upon perfusion with glucose, the muscle interstitial glucose concentration was estimated to be 6.9 +/- 0.3 mM (n = 14), which was not significantly different from the blood glucose level. With insulin infusion (1200 mU kg-1 body wt i.v.), the insulin-induced change in the glucose concentration of the interstitial space of muscle was of equal magnitude to that of blood and adipose tissue. In spite of this, when the perfusion medium was not supplemented with glucose, the glucose concentration decreased more in skeletal muscle dialysates (to 36.7 +/- 4.9% of the initial level) than in blood (to 29.7 +/- 5.0%) but less than in adipose tissue (to 17.7 +/- 4.9% of the initial level) (P < 0.05). The results indicate that these differences are due to tissue-specific differences in the dynamic balance between the supply to, and removal from, the interstitial glucose pool. This balance is revealed as a result of the constant glucose drainage by the microdialysis probe. The present results show that, in skeletal muscle, increases in glucose uptake occur with a concomitant increase in tissue blood flow as revealed by the microdialysis ethanol technique, whereas in adipose tissue the glucose uptake increases in the absence of a corresponding increase in blood flow.

sted, utgiver, år, opplag, sider
1994. Vol. 151, nr 2, s. 249-60
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Identifikatorer
URN: urn:nbn:se:gih:diva-1079PubMedID: 7942061OAI: oai:DiVA.org:gih-1079DiVA, id: diva2:284675
Tilgjengelig fra: 2010-01-08 Laget: 2010-01-08 Sist oppdatert: 2017-12-12bibliografisk kontrollert
Inngår i avhandling
1. Microdialysis sampling from skeletal muscle and adipose tissue with special reference to the effects of insulin on tissue blood flow and glucose metabolism
Åpne denne publikasjonen i ny fane eller vindu >>Microdialysis sampling from skeletal muscle and adipose tissue with special reference to the effects of insulin on tissue blood flow and glucose metabolism
1998 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Stockholm: Norstedts Tryckeri AB, 1998. s. 56
Emneord
microdialysis, insulin, skeletal muscle, adipose tissue, glucose, amino acids
HSV kategori
Identifikatorer
urn:nbn:se:gih:diva-1082 (URN)91-628-3050-3 (ISBN)
Disputas
1998-06-12, Aulan, GIH, Lidingövägen 1, Stockholm, 09:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2010-01-08 Laget: 2010-01-08 Sist oppdatert: 2017-03-01bibliografisk kontrollert

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