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Biphasic relationship between training load and glucose tolerance
Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, Åstrandlaboratoriet.ORCID-id: 0000-0001-8314-7814
Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, Åstrandlaboratoriet.ORCID-id: 0000-0002-7743-9295
Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, Åstrandlaboratoriet, Eva Blomstrands forskningsgrupp.ORCID-id: 0000-0003-1942-2919
Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, Åstrandlaboratoriet, Björn Ekbloms forskningsgrupp.ORCID-id: 0000-0002-4030-5437
Vise andre og tillknytning
2019 (engelsk)Konferansepaper, Poster (with or without abstract) (Annet vitenskapelig)
Abstract [sv]

Biphasic relationship between training load and glucose tolerance

Nilsson, L, Flockhart M, Bergman K, Apro W, Ekblom B, Larsen FJ

 

There is a well-established construct regarding the positive effects of exercise on glucose tolerance and insulin sensitivity, as well as muscle glycogen storage. In insulin resistance, physical activity is an essential part of the treatment. However, the optimal dose is unknown. Reduced muscular glycogen stores, resulting from exercise, should stimulate an increased uptake of blood glucose. In this study we investigated the relation between training load, glucose tolerance and insulin sensitivity during three weeks of increasing interval training. Three times during the intervention, oral glucose tests were conducted to investigate the rate of glucose uptake. We found a biphasic dose-response relationship between training load and glucose tolerance, where an excessive training load led to a paradoxical reduction in glucose tolerance and impaired insulin release despite an unchanged amount of muscle glycogen. In light of these results, an upper limit of physical exercise exist where the negative effects overpowers the positive.

sted, utgiver, år, opplag, sider
2019.
HSV kategori
Forskningsprogram
Medicin/Teknik; Medicin/Teknik; Medicin/Teknik
Identifikatorer
URN: urn:nbn:se:gih:diva-5933OAI: oai:DiVA.org:gih-5933DiVA, id: diva2:1374367
Konferanse
Cell Symposia, Exercise Metabolism. May 5-7 2019, Sitges Spain
Forskningsfinansiär
Swedish National Centre for Research in SportsTilgjengelig fra: 2019-11-29 Laget: 2019-11-29 Sist oppdatert: 2019-12-09bibliografisk kontrollert

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Nilsson, LinaFlockhart, MikaelApro, WilliamEkblom, BjörnLarsen, Filip J

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