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Exercise intensity-dependent immunomodulatory effects on encephalomyelitis.
Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
Ariel University, Ariel, Israel.
AHEPA University Hospital of Thessaloniki, Thessaloniki, Greece..
AHEPA University Hospital of Thessaloniki, Thessaloniki, Greece..
Vise andre og tillknytning
2019 (engelsk)Inngår i: Annals of Clinical & Translational Neurology, ISSN 2328-9503, Vol. 6, nr 9, s. 1647-1658Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Exercise training (ET) has beneficial effects on multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). However, the intensity-dependent effects of ET on the systemic immune system in EAE remain undefined.

OBJECTIVE: (1) To compare the systemic immune modulatory effects of moderate versus high-intensity ET protocols in protecting against development of EAE; (2) To investigate whether ET affects autoimmunity selectively, or causes general immunosuppression.

METHODS: Healthy mice performed moderate or high-intensity treadmill running programs. Proteolipid protein (PLP)-induced transfer EAE was utilized to examine ET effects specifically on the systemic immune system. Lymph node (LN)-T cells from trained versus sedentary donor mice were transferred to naïve recipients and EAE severity was assessed, by clinical assessment and histopathological analysis. LN-T cells derived from donor trained versus sedentary PLP-immunized mice were analyzed in vitro for proliferation assays by flow cytometry analysis and cytokine and chemokine receptor gene expression using real-time PCR. T cell-dependent immune responses of trained versus sedentary mice to the nonautoantigen ovalbumin and susceptibility to Escherichia coli-induced acute peritonitis were examined.

RESULTS: High-intensity training in healthy donor mice induced significantly greater inhibition than moderate-intensity training on proliferation and generation of encephalitogenic T cells in response to PLP-immunization, and on EAE severity upon their transfer into recipient mice. High-intensity training also inhibited LN-T cell proliferation in response to ovalbumin immunization. E. coli bacterial counts and dissemination were not affected by training.

INTERPRETATION: High-intensity training induces superior effects in preventing autoimmunity in EAE, but does not alter immune responses to E. coli infection.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2019. Vol. 6, nr 9, s. 1647-1658
HSV kategori
Forskningsprogram
Medicin/Teknik
Identifikatorer
URN: urn:nbn:se:gih:diva-5833DOI: 10.1002/acn3.50859ISI: 000479180500001PubMedID: 31368247OAI: oai:DiVA.org:gih-5833DiVA, id: diva2:1351593
Tilgjengelig fra: 2019-09-16 Laget: 2019-09-16 Sist oppdatert: 2019-10-29

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