Gymnastik- och idrottshögskolan, GIH

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Title [sv]
Vad kan motorisk funktion berätta om normalt kognitivt åldrande och demenssjukdomar? Ett multidisciplinärt förhållningssätt för precisionsmedicin
Title [en]
What can motor function tell us about cognitive aging and dementia? A multidisciplinary approach towards precision medicine
Abstract [sv]
Motorisk prestation spelar en viktig roll vid åldrande och demens då man är medveten om att hjärnan också kontrollerar och koordinerar komponenter i det neuromuskulära systemet. Ju lägre gånghastigheten är och ju mer gånghastigheten minskar med åldern, desto högre risk att utveckla demens. Således kan gångtest och gångprofil bli en markör för demensdiagnos och förutsägelse.

Detta projekt kommer att fokusera på kognitiv-motorisk interaktion över olika kontinuum av demensfaser: normal kognition, prekliniskt stadium, till demens. Utifrån projektet kommer vi att svara på följande frågor:
Om och i vilken utsträckning kan motorisk profil användas som en tidig bedömning för att identifiera individer med en potentiell risk för demens?
Vad är mekanismen bakom kognitiv-motorisk interaktion?
Kan gångegenskaper användas för att förutsäga den kliniska utvecklingen hos patienter med lindrig kognitiv funktionsnedsättning?
Kan nedgången i gånghastighet och kognitiv förmåga förebyggas samtidigt?

Vi planerar att genomföra epidemiologiska studier som inkluderar äldre vuxna utan kognitiva symtom, patienter med kognitiv funktionsnedsättning samt äldre vuxna med hög risk för demens. Insamling av data om motorisk funktion kommer att genomföras både i laboratorie- och boendemiljöer.

Detta projekt har klinisk betydelse för tidig diagnos och förebyggande av demens. Vi hoppas att resultaten av vår studie kommer att gynna hela samhället genom att minska bördan av demens.
Publications (3 of 3) Show all publications
Larsson, L. E., Wang, R., Cederholm, T., Wiggenraad, F., Rydén, M., Hagman, G., . . . Thunborg, C. (2023). Association of Sarcopenia and Its Defining Components with the Degree of Cognitive Impairment in a Memory Clinic Population.. Journal of Alzheimer's Disease, 96(2), 777-788
Open this publication in new window or tab >>Association of Sarcopenia and Its Defining Components with the Degree of Cognitive Impairment in a Memory Clinic Population.
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2023 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 96, no 2, p. 777-788Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Sarcopenia and cognitive impairment are two leading causes of disabilities.

OBJECTIVE: The objective was to examine the prevalence of sarcopenia and investigate the association between sarcopenia diagnostic components (muscle strength, muscle mass, and physical performance) and cognitive impairment in memory clinic patients.

METHODS: 368 patients were included (age 59.0±7.25 years, women: 58.7%), displaying three clinical phenotypes of cognitive impairments, i.e., subjective cognitive impairment (SCI, 57%), mild cognitive impairment (MCI, 26%), and Alzheimer's disease (AD, 17%). Sarcopenia was defined according to diagnostic algorithm recommended by the European Working Group on Sarcopenia in Older People. Components of sarcopenia were grip strength, bioelectrical impedance analysis, and gait speed. They were further aggregated into a score (0-3 points) by counting the numbers of limited components. Multi-nominal logistic regression was applied.

RESULTS: Probable sarcopenia (i.e., reduced grip strength) was observed in 9.6% of the patients, and 3.5% were diagnosed with sarcopenia. Patients with faster gait speed showed less likelihood of MCI (odds ratio [OR]: 0.24, 95% confidence interval [CI]: 0.06-0.90) and AD (OR: 0.12, 95% CI: 0.03-0.60). One or more limited sarcopenia components was associated with worse cognitive function. After adjusting for potential confounders, the association remained significant only for AD (OR 4.29, 95% CI 1.45-11.92).

CONCLUSION: The results indicate a connection between the sarcopenia components and cognitive impairments. Limitations in the sarcopenia measures, especially slow walking speed, were related to poorer cognitive outcomes. More investigationsare required to further verify the causal relationship between sarcopenia and cognitive outcomes.

Place, publisher, year, edition, pages
IOS Press, 2023
Keywords
Alzheimer’s disease, body composition, cognitive function, gait speed, hand grip strength, outpatients, sarcopenia, E-PABS, EPABS, hjärnhälsa, brain health
National Category
Geriatrics Neurology
Research subject
Medicine/Technology
Identifiers
urn:nbn:se:gih:diva-7949 (URN)10.3233/JAD-221186 (DOI)001099536400028 ()37899056 (PubMedID)
Funder
Swedish Research Council, 2022-01404Knowledge Foundation, 2018-0151, 2021-0002, 2022-0202The Karolinska Institutet's Research Foundation, 2022-02248
Available from: 2023-11-20 Created: 2023-11-20 Last updated: 2024-03-22
Wu, J., Xiong, Y., Xia, X., Orsini, N., Qiu, C., Kivipelto, M., . . . Wang, R. (2023). Can dementia risk be reduced by following the American Heart Association's Life's Simple 7?: A systematic review and dose-response meta-analysis.. Ageing Research Reviews, 83, Article ID 101788.
Open this publication in new window or tab >>Can dementia risk be reduced by following the American Heart Association's Life's Simple 7?: A systematic review and dose-response meta-analysis.
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2023 (English)In: Ageing Research Reviews, ISSN 1568-1637, E-ISSN 1872-9649, Vol. 83, article id 101788Article in journal (Refereed) Published
Abstract [en]

This study aimed to quantify the relationships between the American Heart Association (AHA) Cardiovascular Health (CVH) metrics, namely AHA Life's Simple 7, and cognitive outcomes. We searched PubMed and Embase (January 1, 2010-August 24, 2022) and finally included 14 longitudinal studies (311654 participants with 8006 incident dementia cases). Random-effects meta-analysis and one-stage linear mixed-effects models were performed. Increased CVH score seemed to associate with decreased risk of incident dementia in a linear manner, but this relationship varied by the measurement age of CVH metrics. That is, midlife CVH tended to have a linear association with late-life dementia risk, whereas a J-shaped association was observed between the late-life CVH score and dementia. In addition, late-life dementia risk was reduced significantly if individuals maintained an ideal level of AHA's CVH guidelines of physical activity, fasting plasma glucose, total cholesterol, and smoking. However, our meta-analysis did not show a significant association between CVH score and global cognitive decline rate. Following AHA's CVH guidelines and maintaining CVH at an optimal level would substantially reduce the late-life dementia risk. More research is required to explore the link between a favorable CVH score and cognitive trajectories among cognitively asymptomatic older populations.

Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
Cardiovascular health, Dementia, Global cognitive function, Life’s Simple 7, Meta-analysis, E-PABS, EPABS, brain health, hjärnhälsa
National Category
Geriatrics
Research subject
Medicine/Technology
Identifiers
urn:nbn:se:gih:diva-7425 (URN)10.1016/j.arr.2022.101788 (DOI)000974976400001 ()36371016 (PubMedID)
Available from: 2022-12-02 Created: 2022-12-02 Last updated: 2024-03-26
Wang, R., Dekhtyar, S. & Wang, H.-X. (2023). Cognitive Reserve: A Life-Course Perspective. In: Petrosini, Laura (Ed.), Neurobiological and Psychological Aspects of Brain Recovery: (pp. 121-135). Springer Publishing Company
Open this publication in new window or tab >>Cognitive Reserve: A Life-Course Perspective
2023 (English)In: Neurobiological and Psychological Aspects of Brain Recovery / [ed] Petrosini, Laura, Springer Publishing Company, 2023, p. 121-135Chapter in book (Other academic)
Abstract [en]

The concept of reserve has been developed to account for the discontinuity between the extent of brain damage at its clinical manifestation in the form of cognitive decline or dementia. In this chapter, we discuss contributors to cognitive reserve from various stages of the life-course, including childhood, early adulthood, middle age, and late life. Evidence from observational studies as well as intervention trials is presented and assessed. We conclude by arguing that reserve formation in dementia risk is a life-course process whereby baseline cognitive abilities are subjected to modulation by subsequent experiences at diverse stages over the entire life-course. Variations among individuals in their ability to withstand age-related brain changes are ultimately dependent on their life-time accumulation of mental, physical, and lifestyle inputs into cognitive reserve.

Place, publisher, year, edition, pages
Springer Publishing Company, 2023
National Category
Neurosciences
Research subject
Medicine/Technology
Identifiers
urn:nbn:se:gih:diva-7675 (URN)10.1007/978-3-031-24930-3_5 (DOI)978-3-031-24930-3 (ISBN)978-3-031-24929-7 (ISBN)978-3-031-24932-7 (ISBN)
Available from: 2023-06-27 Created: 2023-06-27 Last updated: 2023-06-27
Principal InvestigatorWang, Rui
Co-InvestigatorEkblom, Maria
Co-InvestigatorHeiland, Emerald G.
Co-InvestigatorKivipelto, Miia
Co-InvestigatorThunborg, Charlotta
Coordinating organisation
Swedish School of Sport and Health Sciences, GIH
Funder
Period
2023-01-01 - 2026-12-31
Keywords [en]
Geriatric Epidemiology, Public Health, Neurosciences, Kinetic Science, Precision Medicine
National Category
GeriatricsPublic Health, Global Health, Social Medicine and Epidemiology
Identifiers
DiVA, id: project:2942Project, id: VR 2022-01404