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Title [sv]
Tvillingprojektet – Tvillingbaserade studier om betydelsen av arv och miljö för sambanden mellan fysiskt aktivitetsmönster och ungdomars hjärnhälsa
Title [en]
The twin project – Twin-based studies on the importance of genes and environment in associations between physical activity patterns and brain health in adolescents
Abstract [sv]
Epidemiologiska studier har ofta begränsade möjligheter att identifiera orsakssamband. Detta gäller särskilt för situationer där orsakssambanden kan vara dubbelriktade. Genom att studera hälsa och levnadsvanor hos enäggs- och tvåäggstvillingar är det dock möjligt att modellera i vilken utsträckning skillnader i en eller flera egenskaper, kan hänföras till arv, gemensamma miljöfaktorer (något som båda tvillingarna upplevt, såsom uppväxtfaktorer) eller unika miljöfaktorer (något som bara den ena tvillingen upplevt, såsom deltagande i en viss aktivitet, skolfaktorer eller något de råkat ut för). Tvillingbaserade studier är inte så vanliga eftersom de kräver mycket information från en stor grupp både enäggs- och tvåäggstvillingar. Att skapa sådana register kräver lång tid och omfattande arbete. I Sverige finns Svenska Tvillingregistret (STR) som en nationell forskningsresurs. GIH är genom E-PABS medlemmar av STRs i nationella råd och bidrar med mätningar av fysisk aktivitet baserad på sensorbaserad metodik till registret. Tidigare studier saknas av hur arv respektive miljö inverkar på sambandet mellan det fysiska aktivitetsmönstret och om det finns faktorer i arv eller miljö som påverkar sambandet mellan fysisk aktivitet och hälsoutfall. Även om självrapporterad data på fysisk aktivitet är informativ, är den sensorbaserade data man samlar in med till exempel accelerometrar avsevärt mer detaljerad.

I de första två STR-baserade studier undersöker vi arvsmässiga och miljömässiga bidrag till fysisk aktivitet och psykisk hälsa, samt hur dessa samvarierar hos barn som är nio och 15 år. I en studie undersöker vi hur fysisk aktivitet i nio års ålder påverkar psykisk hälsa i 15-årsåldern och i vilken utsträckning miljö eller arv kan kopplas till ett sådant samband.

I en annan studie studeras arvsmässiga och miljömässiga bidrag till detaljerade mått på nioåringars fysiska aktivitetsmönster och hur dessa mått relaterar till samband mellan neuropsykiatriska tillstånd och psykisk hälsa.
Abstract [en]
In this project genetic and environmental contributions to the relationship between physical activity and mental health will be investigated. This is a collaboration with the Swedish twin registry, in which we will initially collect device-measured physical activity data from 1500 nine year old twins, and follow them with new data collections on health and physical activity outcomes every third year. This data set is unique in that it allows us to calculate the importance of genetics versus environment on physical activity patterns (including time spent sedentary) and mental health, as well as relationships between the two. The dataset also contains information sociodemographic variables, neuropsychiatric symptoms and diagnoses and will be used to investigate genetic and environmental contributions to the relation between physical activity patterns and neuropsychiatric symptoms. This project will run throughout the proposed research profile and will allow us to investigate cross-sectional relationships first, and longitudinal relationships later. The twin registry collects a large battery of mental health questionnaires and also performs complete genome sequencing on all children whose parents provided informed consent. Data collection to this first cohort started in June 2020. Knowledge will be co-produced with our business partners IKEA, SATS and Skandia, who have participated in designing the initial research questions, and will contribute intellectually to the analysis plan.
Publications (2 of 2) Show all publications
Wiklund, C. A., Ekblom, M. M., Wang, R. & Ekblom, Ö. (2025). Associations Between Physical Activity and Symptoms of Mental Health Disorders in Adolescence: Evidence From the Longitudinal Swedish Twin Register.. Journal of Adolescent Health, 76(3), 370-378
Open this publication in new window or tab >>Associations Between Physical Activity and Symptoms of Mental Health Disorders in Adolescence: Evidence From the Longitudinal Swedish Twin Register.
2025 (English)In: Journal of Adolescent Health, ISSN 1054-139X, E-ISSN 1879-1972, Vol. 76, no 3, p. 370-378Article in journal (Refereed) Published
Abstract [en]

PURPOSE: The transition phase between childhood and adolescence is critical, given the observation of increased mental health issues during this period, coupled with the absence of efficient intervention tools. This study aims to examine a possible effect of physical activity on mental health symptoms in adolescents during this transitional age.

METHODS: We used data from a large-scale population-based Swedish twin sample of 14,083 individuals to investigate cross-sectional and longitudinal associations between physical activity and mental health problems during childhood and adolescence. We examine different aspects of mental health symptoms, including internalizing and externalizing symptoms. We applied generalized estimating equations to investigate the associations and explored potential familial confounding using within-twin pair analysis.

RESULTS: We found high physical activity intensity and frequency to be associated with better mental health throughout childhood and adolescence, cross-sectionally and longitudinally. Compared to those who reported low, those reporting high physical activity intensity and frequency in both childhood and/or adolescence had significantly lower symptoms of mental health at age 15. This association was statistically significant for both internalizing and externalizing symptoms. The within-twin pair analysis showed that familial confounding factors can largely explain the association with the externalizing scale, but not the internalizing scale.

DISCUSSION: Physical activity in childhood and adolescence may play an essential role in reducing the risk of developing mental health problems, especially internalizing symptoms. Implementing acceptable, low-risk, and cost-effective interventions to promote physical activity could effectively safeguard young individuals from these symptoms.

Place, publisher, year, edition, pages
Elsevier, 2025
Keywords
Adolescents, Children, Familial confounding factors, Mental health, Physical activity, Twin studies, epabs, e-pabs, hjärnhälsa, brain health
National Category
Public Health, Global Health and Social Medicine Psychiatry
Research subject
Medicine/Technology; Medicine/Technology
Identifiers
urn:nbn:se:gih:diva-8410 (URN)10.1016/j.jadohealth.2024.10.017 (DOI)001427557200001 ()39580734 (PubMedID)2-s2.0-85210005656 (Scopus ID)
Available from: 2024-12-03 Created: 2024-12-03 Last updated: 2025-03-11
Ekblom, M., Ekblom, Ö., Wiklund, C. & Wang, R. (2023). Environmental and genetic contributions to device-based measures of physical activity in Swedish 9-year-olds.. In: : . Paper presented at ISBNPA, International Society of Behavioral Nutrition and Physical Activity annual meeting, June 14-17, 2023, Uppsala, Sweden.
Open this publication in new window or tab >>Environmental and genetic contributions to device-based measures of physical activity in Swedish 9-year-olds.
2023 (English)Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

 

Keywords
E-PABS, EPABS, hjärnhälsa, brain health
National Category
Other Medical Sciences
Research subject
Medicine/Technology
Identifiers
urn:nbn:se:gih:diva-8062 (URN)
Conference
ISBNPA, International Society of Behavioral Nutrition and Physical Activity annual meeting, June 14-17, 2023, Uppsala, Sweden
Funder
Knowledge FoundationSwedish Research Council
Available from: 2024-01-17 Created: 2024-01-17 Last updated: 2024-03-21Bibliographically approved
Principal InvestigatorEkblom, Örjan
Co-InvestigatorEkblom, Maria
Co-InvestigatorWang, Rui
Co-InvestigatorBlom, Victoria
Co-InvestigatorLönn, Amanda
Co-InvestigatorPontén, Marjan
Co-InvestigatorWiklund, Camilla
Co-InvestigatorHelgadóttir, Björg
Co-InvestigatorOntiveros, Narda
Coordinating organisation
Swedish School of Sport and Health Sciences, GIH
Funder
Period
2022-01-01 - 2028-12-31
National Category
NeurosciencesPublic Health, Global Health, Social Medicine and Epidemiology
Identifiers
DiVA, id: project:2916